Gene/Proteome Database (LMPD)

LMPD ID
LMP012721
Gene ID
65029
Species
Rattus norvegicus (Rat)
Gene Name
amine oxidase, copper containing 1
Gene Symbol
Aoc1
Synonyms
Abp; Abp1;
Alternate Names
amiloride-sensitive amine oxidase [copper-containing]; DAO; histaminase; diamine oxidase; amiloride-binding protein 1; amiloride-sensitive amine oxidase; amine oxidase copper domain-containing protein 1; amiloride binding protein 1 (amine oxidase, copper-containing);
Chromosome
4
Map Location
4q24
Summary
binds amiloride and some of its derivatives; may form an epithelial-specific Na+ channel [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Aoc1

Proteins

amiloride-sensitive amine oxidase [copper-containing] precursor
Refseq ID NP_075224
Protein GI 144226253
UniProt ID Q498N2
mRNA ID NM_022935
Length 751
MRLAQMCLAFGWAAVILVLQTVDTASAVRTPYDKARVFADLSPQEIKAVHSFLMNREELGLQPSKEPTLAKNSVFLIEMLLPKKKHVLKFLDEGRKGPNREARAVIFFGAQDYPNVTEFAVGPLPRPYYIRALSPRPGHHLSWSSRPISTAEYDLLYHTLKRATMPLHQFFLDTTGFSFLGCDDRCLTFTDVAPRGVASGQRRSWFIVQRYVEGYFLHPTGLEILLDHGSTDVQDWRVEQLWYNGKFYNNPEELARKYAVGEVDTVVLEDPLPNGTEKPPLFSSYKPRGEFHTPVNVAGPHVVQPSGPRYKLEGNTVLYGGWSFSYRLRSSSGLQIFNVLFGGERVAYEVSVQEAVALYGGHTPAGMQTKYIDVGWGLGSVTHELAPGIDCPETATFLDAFHYYDSDGPVHYPHALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGYVLVLRTTSTVYNYDYIWDFIFYSNGVMEAKMHATGYVHATFYTPEGLRHGTRLQTHLLGNIHTHLVHYRVDMDVAGTKNSFQTLTMKLENLTNPWSPSHSLVQPTLEQTQYSQEHQAAFRFGQTLPKYLLFSSPQKNCWGHRRSYRLQIHSMAEQVLPPGWQEERAVTWARYPLAVTKYRESERYSSSLYNQNDPWDPPVVFEEFLRNNENIEDEDLVAWVTVGFLHIPHSEDVPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPQDKGLNRVQRWIPEDRRCLVSPPFSYNGTYKPV
sig_peptide: 1..27 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2880 peptide sequence: MRLAQMCLAFGWAAVILVLQTVDTASA

Gene Information

Entrez Gene ID
65029
Gene Name
amine oxidase, copper containing 1
Gene Symbol
Aoc1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005507 IEA:InterPro F copper ion binding
GO:0008131 IEA:InterPro F primary amine oxidase activity
GO:0048038 IEA:InterPro F quinone binding
GO:0009308 IEA:InterPro P amine metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00330 Arginine and proline metabolism
rno00330 Arginine and proline metabolism
ko00340 Histidine metabolism
rno00340 Histidine metabolism
ko00380 Tryptophan metabolism
rno00380 Tryptophan metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000269 Cu_amine_oxidase
IPR015798 Cu_amine_oxidase_C
IPR015800 Cu_amine_oxidase_N2
IPR015801 Cu_amine_oxidase_N2/3
IPR015802 Cu_amine_oxidase_N3
IPR016182 Cu_amine_oxidase_N-reg

UniProt Annotations

Entry Information

Gene Name
amine oxidase, copper containing 1
Protein Entry
Q498N2_RAT
UniProt ID
Q498N2
Species
Rat

Comments

Comment Type Description
Ptm Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue
Similarity Belongs to the copper/topaquinone oxidase family

Identical and Related Proteins

Unique RefSeq proteins for LMP012721 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
144226253 RefSeq NP_075224 751 amiloride-sensitive amine oxidase [copper-containing] precursor

Identical Sequences to LMP012721 proteins

Reference Database Accession Length Protein Name
GI:144226253 GenBank AAI00145.1 751 Abp1 protein [Rattus norvegicus]
GI:144226253 GenBank EDL88224.1 751 amiloride binding protein 1 (amine oxidase, copper-containing), isoform CRA_b [Rattus norvegicus]
GI:144226253 RefSeq XP_006236533.1 751 PREDICTED: amiloride-sensitive amine oxidase [copper-containing] isoform X1 [Rattus norvegicus]
GI:144226253 RefSeq XP_006236534.1 751 PREDICTED: amiloride-sensitive amine oxidase [copper-containing] isoform X1 [Rattus norvegicus]

Related Sequences to LMP012721 proteins

Reference Database Accession Length Protein Name
GI:144226253 GenBank AAI00145.1 751 Abp1 protein [Rattus norvegicus]
GI:144226253 GenBank EDL88224.1 751 amiloride binding protein 1 (amine oxidase, copper-containing), isoform CRA_b [Rattus norvegicus]
GI:144226253 RefSeq XP_006236533.1 751 PREDICTED: amiloride-sensitive amine oxidase [copper-containing] isoform X1 [Rattus norvegicus]