Gene/Proteome Database (LMPD)
LMPD ID
LMP012723
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
syntaxin 12
Gene Symbol
Alternate Names
syntaxin-12; Syn13; syntaxin-13;
Chromosome
5
Map Location
5q36
Summary
member of the syntaxin family; binds alpha SNAP and syndet/SNAP-23 in vitro; may play a role in vesicle-mediated transport [RGD, Feb 2006]
Orthologs
Proteins
syntaxin-12 | |
---|---|
Refseq ID | NP_075228 |
Protein GI | 77695930 |
UniProt ID | G3V7P1 |
mRNA ID | NM_022939 |
Length | 274 |
MSYGPLDMYRNPGPSGPQPRDFNSIIQTCSGNIQRISQATAQIKNLMSQLGTKQDSSKLQENLQQFQHSTNQLAKETNELLKELGSLPLPLSASEQRQQKLQKERLMNDFSSALNNFQVVQRKVSEKEKESIARARAGSRLSAEDRQREEQLVSFDSHEEWNQMQSQEEEAAITEQDLELIKERETAIQQLEADILDVNQIFKDLAMMIHDQGDLIDSIEANVESSEVHVERASDQLQRAAYYQKKSRKKMCILVLVLSVIVTVLVVVIWVASK |
Gene Information
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0031083 | IEA:Ensembl | C | BLOC-1 complex |
GO:0005768 | IEA:UniProtKB-KW | C | endosome |
GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
GO:0045121 | IEA:Ensembl | C | membrane raft |
GO:0045335 | IEA:Ensembl | C | phagocytic vesicle |
GO:0031201 | ISS:UniProtKB | C | SNARE complex |
GO:0005484 | IBA:RefGenome | F | SNAP receptor activity |
GO:0000149 | IBA:RefGenome | F | SNARE binding |
GO:0033344 | IEA:Ensembl | P | cholesterol efflux |
GO:0006886 | IBA:RefGenome | P | intracellular protein transport |
GO:0050821 | IEA:Ensembl | P | protein stabilization |
GO:0016079 | IBA:RefGenome | P | synaptic vesicle exocytosis |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Function | SNARE that acts to regulate protein transport between endosomes and the trans-Golgi network (By similarity). The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) |
Interaction | Q63666:Vamp1; NbExp=3; IntAct=EBI-915654, EBI-2029956; |
Sequence Caution | Sequence=AAC18967.1; Type=Frameshift; Positions=2; Evidence= ; |
Similarity | Belongs to the syntaxin family |
Similarity | Contains 1 t-SNARE coiled-coil homology domain |
Subcellular Location | Endosome membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Endomembrane system ; Single-pass type IV membrane protein ; Cytoplasmic side . |
Subunit | Associates with the BLOC-1 complex. Interacts with BLOC1S6 (By similarity). Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A. {ECO:0000250, ECO:0000269|PubMed:17159904, ECO:0000269|PubMed:9507000}. |
Tissue Specificity | Ubiquitous. Highly expressed in brain |
Identical and Related Proteins
Unique RefSeq proteins for LMP012723 (as displayed in Record Overview)
Identical Sequences to LMP012723 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:77695930 | GenBank | EDL80653.1 | 274 | syntaxin 12 [Rattus norvegicus] |
GI:77695930 | SwissProt | G3V7P1.1 | 274 | RecName: Full=Syntaxin-12; AltName: Full=Syntaxin-13 [Rattus norvegicus] |
Related Sequences to LMP012723 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:77695930 | DBBJ | BAE27249.1 | 274 | unnamed protein product [Mus musculus] |
GI:77695930 | GenBank | EDL80653.1 | 274 | syntaxin 12 [Rattus norvegicus] |
GI:77695930 | SwissProt | G3V7P1.1 | 274 | RecName: Full=Syntaxin-12; AltName: Full=Syntaxin-13 [Rattus norvegicus] |