Gene/Proteome Database (LMPD)

LMPD ID
LMP012723
Gene ID
65033
Species
Rattus norvegicus (Rat)
Gene Name
syntaxin 12
Gene Symbol
Stx12
Alternate Names
syntaxin-12; Syn13; syntaxin-13;
Chromosome
5
Map Location
5q36
Summary
member of the syntaxin family; binds alpha SNAP and syndet/SNAP-23 in vitro; may play a role in vesicle-mediated transport [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Stx12

Proteins

syntaxin-12
Refseq ID NP_075228
Protein GI 77695930
UniProt ID G3V7P1
mRNA ID NM_022939
Length 274
MSYGPLDMYRNPGPSGPQPRDFNSIIQTCSGNIQRISQATAQIKNLMSQLGTKQDSSKLQENLQQFQHSTNQLAKETNELLKELGSLPLPLSASEQRQQKLQKERLMNDFSSALNNFQVVQRKVSEKEKESIARARAGSRLSAEDRQREEQLVSFDSHEEWNQMQSQEEEAAITEQDLELIKERETAIQQLEADILDVNQIFKDLAMMIHDQGDLIDSIEANVESSEVHVERASDQLQRAAYYQKKSRKKMCILVLVLSVIVTVLVVVIWVASK

Gene Information

Entrez Gene ID
65033
Gene Name
syntaxin 12
Gene Symbol
Stx12
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031083 IEA:Ensembl C BLOC-1 complex
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0031201 ISS:UniProtKB C SNARE complex
GO:0005768 IEA:UniProtKB-KW C endosome
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0045121 IEA:Ensembl C membrane raft
GO:0045335 IEA:Ensembl C phagocytic vesicle
GO:0005484 IBA:RefGenome F SNAP receptor activity
GO:0000149 IBA:RefGenome F SNARE binding
GO:0033344 IEA:Ensembl P cholesterol efflux
GO:0006886 IBA:RefGenome P intracellular protein transport
GO:0050821 IEA:Ensembl P protein stabilization
GO:0016079 IBA:RefGenome P synaptic vesicle exocytosis

KEGG Pathway Links

KEGG Pathway ID Description
ko04145 Phagosome
rno04145 Phagosome

Domain Information

InterPro Annotations

Accession Description
IPR006011 Syntaxin, N-terminal domain
IPR006012 Syntaxin/epimorphin, conserved site
IPR000727 Target SNARE coiled-coil domain
IPR010989 t-SNARE

UniProt Annotations

Entry Information

Gene Name
syntaxin 12
Protein Entry
STX12_RAT
UniProt ID
G3V7P1
Species
Rat

Comments

Comment Type Description
Function SNARE that acts to regulate protein transport between endosomes and the trans-Golgi network (By similarity). The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro)
Interaction Q63666:Vamp1; NbExp=3; IntAct=EBI-915654, EBI-2029956;
Sequence Caution Sequence=AAC18967.1; Type=Frameshift; Positions=2; Evidence= ;
Similarity Belongs to the syntaxin family
Similarity Contains 1 t-SNARE coiled-coil homology domain
Subcellular Location Endosome membrane; Single-pass type IV membrane protein. Golgi apparatus membrane; Single-pass type IV membrane protein. Endomembrane system ; Single-pass type IV membrane protein ; Cytoplasmic side .
Subunit Associates with the BLOC-1 complex. Interacts with BLOC1S6 (By similarity). Interacts with NAPA and SNAP23. Identified in a complex containing STX6, STX12, VAMP4 and VTI1A. {ECO:0000250, ECO:0000269|PubMed:17159904, ECO:0000269|PubMed:9507000}.
Tissue Specificity Ubiquitous. Highly expressed in brain

Identical and Related Proteins

Unique RefSeq proteins for LMP012723 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
77695930 RefSeq NP_075228 274 syntaxin-12

Identical Sequences to LMP012723 proteins

Reference Database Accession Length Protein Name
GI:77695930 GenBank EDL80653.1 274 syntaxin 12 [Rattus norvegicus]
GI:77695930 SwissProt G3V7P1.1 274 RecName: Full=Syntaxin-12; AltName: Full=Syntaxin-13 [Rattus norvegicus]

Related Sequences to LMP012723 proteins

Reference Database Accession Length Protein Name
GI:77695930 DBBJ BAE27249.1 274 unnamed protein product [Mus musculus]
GI:77695930 GenBank EDL80653.1 274 syntaxin 12 [Rattus norvegicus]
GI:77695930 SwissProt G3V7P1.1 274 RecName: Full=Syntaxin-12; AltName: Full=Syntaxin-13 [Rattus norvegicus]