Gene/Proteome Database (LMPD)

LMPD ID
LMP012726
Gene ID
65052
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol 3-kinase, catalytic subunit type 3
Gene Symbol
Pik3c3
Alternate Names
phosphatidylinositol 3-kinase catalytic subunit type 3; PI3K type 3; PI-3K Vps34p; PI3-kinase type 3; ptdIns-3-kinase type 3; phosphoinositide-3-kinase, class 3; catalytic phosphatidylinositol 3-kinase 3;
Chromosome
18
Map Location
18p12
EC Number
2.7.1.137
Summary
activation and intracellular signaling mediates leukotriene B4-induced chemotaxis, generation of reactive oxygen species, and degranulation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pik3c3

Proteins

phosphatidylinositol 3-kinase catalytic subunit type 3
Refseq ID NP_075247
Protein GI 12621140
UniProt ID O88763
mRNA ID NM_022958
Length 887
MGEAEKFHYIYSCDLDINVQLKIGSLEGKREQKSYKAVLEDPMLKFSGLYQETCSDLYVTCQVFAEGKPLALPVRTSYKPFSTRWNWNEWLKLPVKYPDLPRNAQVALTIWDVYGPGRAVPVGGTTVSLFGKYGMFRQGMHDLKVWPNVEADGSEPTRTPGRTSSTLSEDQMSRLAKLTKAHRQGHMVKVDWLDRLTFREIEMINESEKRSSNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMENLVESKHHKLARSLRSGPSDHDLKPNATTRDQLNIIVSYPPTKQLTYEEQDLVWKFRYYLTNQEKALTKFLKCVNWDLPQEAKQALELLGKWKPMDVEDSLELLSSHYTNPTVRRYAVARLRQADDEDLLMYLLQLVQALKYENFDDIKNGLEPTKKDSQASVSESLSSSGVSSADIDSSQIITNPLPPVASPPPASKSKEVSDGENLEQDLCTFLISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLAAQQTFVDRLVHLMKAVQRESGNRKKKNERLQALLGDNEKMNLSDVELIPLPLEPQVKIRGIIPETATLFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDKLLRKENLDLKLTPYKVLATSTKHGFMQFIQSVPVAEVLDTEGSIQNFFRKYAPSETGPNGISAEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPLPPPMKLNKEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLMVDANIPDIALEPDKTVKKVQDKFRLDLSDEEAVHYMQSLIDESVHALFAAVVEQIHKFAQYWRK

Gene Information

Entrez Gene ID
65052
Gene Name
phosphatidylinositol 3-kinase, catalytic subunit type 3
Gene Symbol
Pik3c3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005930 ISS:UniProtKB C axoneme
GO:0005770 ISS:UniProtKB C late endosome
GO:0030496 ISS:UniProtKB C midbody
GO:0045335 IEA:Ensembl C phagocytic vesicle
GO:0005942 IBA:RefGenome C phosphatidylinositol 3-kinase complex
GO:0016303 IDA:RGD F 1-phosphatidylinositol-3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035004 IMP:RGD F phosphatidylinositol 3-kinase activity
GO:0004672 IEA:Ensembl F protein kinase activity
GO:0000045 IMP:RGD P autophagic vacuole assembly
GO:0000910 ISS:UniProtKB P cytokinesis
GO:0045022 ISS:UniProtKB P early endosome to late endosome transport
GO:0007032 IMP:RGD P endosome organization
GO:0036092 IDA:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0048015 IDA:RGD P phosphatidylinositol-mediated signaling
GO:0016485 IMP:RGD P protein processing
GO:0050708 IMP:RGD P regulation of protein secretion
GO:0043201 IEP:RGD P response to leucine

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
rno01100 Metabolic pathways
ko04145 Phagosome
rno04145 Phagosome
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
ko04140 Regulation of autophagy
rno04140 Regulation of autophagy
ko05152 Tuberculosis
rno05152 Tuberculosis

REACTOME Pathway Links

REACTOME Pathway ID Description
5953430 IGF1R signaling cascade
5953410 Immune System
5953409 Innate Immune System
5953422 Insulin receptor signalling cascade
5953428 IRS-mediated signalling
5953425 IRS-related events
5953429 IRS-related events triggered by IGF1R
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5953432 PI3K Cascade
5954478 PI Metabolism
5953423 Signaling by Insulin receptor
5953431 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
5953381 Signal Transduction
5954503 Synthesis of PIPs at the early endosome membrane
5954502 Synthesis of PIPs at the Golgi membrane
5954500 Synthesis of PIPs at the late endosome membrane
5953563 Toll Like Receptor 9 (TLR9) Cascade
5953553 Toll-Like Receptors Cascades

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR008290 Phosphatidylinositol 3-kinase, Vps34 type
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR011009 Protein kinase-like domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 3-kinase, catalytic subunit type 3
Protein Entry
PK3C3_RAT
UniProt ID
O88763
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate.
Cofactor Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence= ;
Function Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate which plays a key role in initiation and maturation of autophagosomes. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for the abcission step in cytokinesis. Required for transport from early to late endosomes (By similarity)
Similarity Belongs to the PI3/PI4-kinase family
Similarity Contains 1 C2 PI3K-type domain. {ECO:0000255|PROSITE- ProRule:PRU00880}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Subcellular Location Midbody . Late endosome . Note=Localizes also to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme
Subunit Heterodimer. This subunit, part of a complex composed of regulatory and catalytic subunits, associates with regulatory subunit PIK3R4. Interacts with AMBRA1 (By similarity). Forms a complex with BECN1, PIK3R4 and either UVRAG and KIAA0226/Rubicon, or with ATG14. In this complex, presence of UVRAG and ATG14 are mutually exclusive (By similarity). Part of a complex composed of PIK3R4 and PIK3CB (By similarity). Interacts with RAB7A in the presence of PIK3R4. Interacts with BECN1P1/BECN2 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012726 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
12621140 RefSeq NP_075247 887 phosphatidylinositol 3-kinase catalytic subunit type 3

Identical Sequences to LMP012726 proteins

Reference Database Accession Length Protein Name
GI:12621140 EMBL CAA07199.1 887 phosphatidylinositol 3-kinase [Rattus norvegicus]
GI:12621140 GenBank AAH61981.1 887 Phosphoinositide-3-kinase, class 3 [Rattus norvegicus]
GI:12621140 GenBank EDL76162.1 887 phosphoinositide-3-kinase, class 3 [Rattus norvegicus]
GI:12621140 SwissProt O88763.1 887 RecName: Full=Phosphatidylinositol 3-kinase catalytic subunit type 3; Short=PI3-kinase type 3; Short=PI3K type 3; Short=PtdIns-3-kinase type 3; AltName: Full=Phosphoinositide-3-kinase class 3 [Rattus norvegicus]

Related Sequences to LMP012726 proteins

Reference Database Accession Length Protein Name
GI:12621140 EMBL CAA07199.1 887 phosphatidylinositol 3-kinase [Rattus norvegicus]
GI:12621140 GenBank AAH61981.1 887 Phosphoinositide-3-kinase, class 3 [Rattus norvegicus]
GI:12621140 SwissProt O88763.1 887 RecName: Full=Phosphatidylinositol 3-kinase catalytic subunit type 3; Short=PI3-kinase type 3; Short=PI3K type 3; Short=PtdIns-3-kinase type 3; AltName: Full=Phosphoinositide-3-kinase class 3 [Rattus norvegicus]