Gene/Proteome Database (LMPD)
LMPD ID
LMP012727
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
aldehyde dehydrogenase 3 family, member A2
Gene Symbol
Synonyms
Aldh4; FALDH;
Alternate Names
fatty aldehyde dehydrogenase; msALDH; aldehyde dehydrogenase 4; aldehyde dehydrogenase 3A2; microsomal aldehyde dehydrogenase; aldehyde dehydrogenase family 3 member A2; alcohol dehydrogenase family 3, subfamily A2; aldehyde dehydrogenase family 3, subfamily A2;
Chromosome
10
Map Location
10q22
EC Number
1.2.1.3
Proteins
| fatty aldehyde dehydrogenase | |
|---|---|
| Refseq ID | NP_113919 |
| Protein GI | 166157462 |
| UniProt ID | P30839 |
| mRNA ID | NM_031731 |
| Length | 484 |
| MERQVQRLRQTFRSGRSRPLRFRLQQLEALRRMVQEREKDILAAIAADLSKSELNAYSHEVITILGEIDFMLGNLPELASARPAKKNLLTMMDEAYVQPEPLGVVLIIGAWNYPFVLTLQPLVGAIAAGNAAIVKPSELSENTAKILAELLPQYLDQDLYMIVNGGVEETTELLRQRFDHILYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDRDCDLDVACRRITWGKYMNCGQTCIAPDYILCEASLQDQIVQKIKDTVKDFYGENVKASPDYERIINLRHFKRIKSLLEGQKIAFGGETDEATRYIAPTILTDVDPNSKVMQEEIFGPILPIVSVKNVEEAINFINDREKPLALYIFSHNNKLIKRVIDETSSGGVTGNDVIMHFTVNSLPFGGVGASGMGAYHGKYSFDTFSHQRPCLLKGLKGESVNKLRYPPNSESKVSWSKFFLLKQFNKGRLQLLLLVCLVAVAAVIVKDQL | |
Gene Information
Entrez Gene ID
Gene Name
aldehyde dehydrogenase 3 family, member A2
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005829 | IDA:RGD | C | cytosol |
| GO:0005783 | IDA:HGNC | C | endoplasmic reticulum |
| GO:0042406 | IDA:RGD | C | extrinsic component of endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005634 | IDA:RGD | C | nucleus |
| GO:0004028 | IDA:RGD | F | 3-chloroallyl aldehyde dehydrogenase activity |
| GO:0004029 | IEA:UniProtKB-EC | F | aldehyde dehydrogenase (NAD) activity |
| GO:0004030 | IEA:InterPro | F | aldehyde dehydrogenase [NAD(P)+] activity |
| GO:0046292 | IDA:RGD | P | formaldehyde metabolic process |
| GO:0000302 | IDA:RGD | P | response to reactive oxygen species |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko00330 | Arginine and proline metabolism |
| rno00330 | Arginine and proline metabolism |
| ko00053 | Ascorbate and aldarate metabolism |
| rno00053 | Ascorbate and aldarate metabolism |
| ko00071 | Fatty acid degradation |
| rno00071 | Fatty acid degradation |
| M00135 | GABA biosynthesis, eukaryotes, putrescine => GABA |
| ko00561 | Glycerolipid metabolism |
| rno00561 | Glycerolipid metabolism |
| ko00010 | Glycolysis / Gluconeogenesis |
| rno00010 | Glycolysis / Gluconeogenesis |
| ko00340 | Histidine metabolism |
| rno00340 | Histidine metabolism |
| ko00310 | Lysine degradation |
| rno00310 | Lysine degradation |
| rno01100 | Metabolic pathways |
| ko00040 | Pentose and glucuronate interconversions |
| rno00040 | Pentose and glucuronate interconversions |
| ko00620 | Pyruvate metabolism |
| rno00620 | Pyruvate metabolism |
| ko00380 | Tryptophan metabolism |
| rno00380 | Tryptophan metabolism |
| ko00280 | Valine, leucine and isoleucine degradation |
| rno00280 | Valine, leucine and isoleucine degradation |
| ko00410 | beta-Alanine metabolism |
| rno00410 | beta-Alanine metabolism |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR016162 | Aldehyde dehydrogenase N-terminal domain |
| IPR012394 | Aldehyde dehydrogenase NAD(P)-dependent |
| IPR015590 | Aldehyde dehydrogenase domain |
| IPR016163 | Aldehyde dehydrogenase, C-terminal |
| IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| IPR016161 | Aldehyde/histidinol dehydrogenase |
UniProt Annotations
Entry Information
Gene Name
aldehyde dehydrogenase 3 family, member A2
Protein Entry
AL3A2_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH. |
| Function | Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (By similarity) |
| Ptm | The N-terminus is blocked. |
| Similarity | Belongs to the aldehyde dehydrogenase family |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012727 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 166157462 | RefSeq | NP_113919 | 484 | fatty aldehyde dehydrogenase |
Identical Sequences to LMP012727 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:166157462 | GenBank | EDM04679.1 | 484 | rCG33224, isoform CRA_a [Rattus norvegicus] |
Related Sequences to LMP012727 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:166157462 | GenBank | AAA41555.1 | 484 | aldehyde dehydrogenase [Rattus norvegicus] |
| GI:166157462 | GenBank | EDM04679.1 | 484 | rCG33224, isoform CRA_a [Rattus norvegicus] |
| GI:166157462 | SwissProt | P30839.1 | 484 | RecName: Full=Fatty aldehyde dehydrogenase; AltName: Full=Aldehyde dehydrogenase 4; AltName: Full=Aldehyde dehydrogenase family 3 member A2; AltName: Full=Microsomal aldehyde dehydrogenase; Short=msALDH [Rattus norvegicus] |