Gene/Proteome Database (LMPD)

LMPD ID
LMP012729
Gene ID
65192
Species
Rattus norvegicus (Rat)
Gene Name
solute carrier family 27 (fatty acid transporter), member 2
Gene Symbol
Slc27a2
Alternate Names
very long-chain acyl-CoA synthetase; VLCS; VLACS; FATP-2; THCA-CoA ligase; fatty acid transport protein 2; long-chain-fatty-acid--CoA ligase; solute carrier family 27 member 2; very long-chain-fatty-acid-CoA ligase; fatty-acid-coenzyme A ligase, very long-chain 1; solute carrier family 27 (fatty acid transporter), member 32;
Chromosome
3
Map Location
3q36
EC Number
6.2.1.-
Summary
has very long-chain acyl-CoA synthetase activity; may play a role in fatty acid metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Slc27a2

Proteins

very long-chain acyl-CoA synthetase
Refseq ID NP_113924
Protein GI 13929034
UniProt ID P97524
mRNA ID NM_031736
Length 620
MLPVLYTGLAGLLLLPLLLTCCCPYLLQDVRFFLQLANMARQVRSYRQRRPVRTILHVFLEQARKTPHKPFLLFRDETLTYAQVDRRSNQVARALHDHLGLRQGDCVALFMGNEPAYVWLWLGLLKLGCPMACLNYNIRAKSLLHCFQCCGAKVLLASPELHEAVEEVLPTLKKEGVSVFYVSRTSNTNGVDTVLDKVDGVSADPIPESWRSEVTFTTPAVYIYTSGTTGLPKAATINHHRLWYGTSLALRSGIKAHDVIYTTMPLYHSAALMIGLHGCIVVGATFALRSKFSASQFWDDCRKYNATVIQYIGELLRYLCNTPQKPNDRDHKVKIALGNGLRGDVWREFIKRFGDIHIYEFYASTEGNIGFMNYPRKIGAVGRENYLQKKVVRHELIKYDVEKDEPVRDANGYCIKVPKGEVGLLICKITELTPFFGYAGGKTQTEKKKLRDVFKKGDVYFNSGDLLMIDRENFIYFHDRVGDTFRWKGENVATTEVADIVGLVDFVEEVNVYGVPVPGHEGRIGMASIKMKENYEFNGKKLFQHISEYLPSYSRPRFLRIQDTIEITGTFKHRKVTLMEEGFNPSVIKDTLYFMDDTEKTYVPMTEDIYNAIIDKTLKL

Gene Information

Entrez Gene ID
65192
Gene Name
solute carrier family 27 (fatty acid transporter), member 2
Gene Symbol
Slc27a2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005788 ISS:UniProtKB C endoplasmic reticulum lumen
GO:0005779 IDA:UniProtKB C integral component of peroxisomal membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0005778 IDA:HGNC C peroxisomal membrane
GO:0005777 IDA:RGD C peroxisome
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004467 IMP:UniProtKB F long-chain fatty acid-CoA ligase activity
GO:0031957 ISS:UniProtKB F very long-chain fatty acid-CoA ligase activity
GO:0001676 IMP:UniProtKB P long-chain fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04146 Peroxisome
rno04146 Peroxisome
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR025110 AMP-binding enzyme C-terminal domain
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
solute carrier family 27 (fatty acid transporter), member 2
Protein Entry
S27A2_RAT
UniProt ID
P97524
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Catalytic Activity ATP + a very-long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA.
Function Acyl-CoA synthetase probably involved in bile acid metabolism. Proposed to activate C27 precurors of bile acids to their CoA thioesters derivatives before side chain cleavage via peroxisomal beta-oxidation occurs. In vitro, activates 3-alpha,7- alpha,12-alpha-trihydroxy-5-beta-cholestanate (THCA), the C27 precursor of cholic acid deriving from the de novo synthesis from cholesterol. Does not utilize C24 bile acids as substrates. In vitro, also activates long- and branched-chain fatty acids and may have additional roles in fatty acid metabolism. May be involved in translocation of long-chain fatty acids (LFCA) across membranes (By similarity)
Similarity Belongs to the ATP-dependent AMP-binding enzyme family
Subcellular Location Endoplasmic reticulum membrane ; Multi-pass membrane protein . Peroxisome membrane ; Multi-pass membrane protein . Note=Peripheral membrane associated with the lumenal side of peroxisomes.

Identical and Related Proteins

Unique RefSeq proteins for LMP012729 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13929034 RefSeq NP_113924 620 very long-chain acyl-CoA synthetase

Identical Sequences to LMP012729 proteins

Reference Database Accession Length Protein Name
GI:13929034 GenBank AAE92228.1 620 Sequence 61 from patent US 6348321
GI:13929034 GenBank AAQ80197.1 620 Sequence 61 from patent US 6300096
GI:13929034 GenBank AAS22569.1 620 Sequence 4 from patent US 6664039
GI:13929034 GenBank ABH70748.1 620 Sequence 61 from patent US 7033772

Related Sequences to LMP012729 proteins

Reference Database Accession Length Protein Name
GI:13929034 DBBJ BAA12722.1 620 very-long-chain acyl-CoA synthetase [Rattus norvegicus]
GI:13929034 GenBank AAQ80197.1 620 Sequence 61 from patent US 6300096
GI:13929034 GenBank AAS22569.1 620 Sequence 4 from patent US 6664039