Gene/Proteome Database (LMPD)

LMPD ID
LMP012735
Gene ID
66025
Species
Rattus norvegicus (Rat)
Gene Name
lysophosphatidic acid receptor 3
Gene Symbol
Lpar3
Synonyms
Edg7;
Alternate Names
lysophosphatidic acid receptor 3; LPA-3; snGPCR32; LPA receptor 3; lysophosphatidic acid receptor Edg-7; putative G protein-coupled receptor snGPCR32; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7;
Chromosome
2
Map Location
2q44
Summary
G protein-coupled receptor for lysophosphatidic acid (LPA); may play a role in reproductive tissues [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Lpar3

Proteins

lysophosphatidic acid receptor 3
Refseq ID NP_076459
Protein GI 13095922
UniProt ID Q8K5E0
mRNA ID NM_023969
Length 345
MDFFYNRSNTDTADEWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVITNRKFHFPFYYLLANLAVADFFAGIAYVFLMFNTGPVSKTLTVNRWLLRQGLLDTSLTASLANLLVIAVERHMSIMRMRIHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLIFWTVSNLLAFFIMVVVYVRIYMYVKRKTNVLSPHTSGSISRRRAPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCKQCNVQHVKRWFLLLALLNSVMNPIIYSYKDEDMYNTMRKMICCAPHDSNAERHPSRIPSTIHSRSDTGSQYLEDSISQGQVCNKSSS

Gene Information

Entrez Gene ID
66025
Gene Name
lysophosphatidic acid receptor 3
Gene Symbol
Lpar3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IEA:Ensembl C axon
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0001965 IMP:RGD F G-protein alpha-subunit binding
GO:0070915 IEA:InterPro F lysophosphatidic acid receptor activity
GO:0005543 IDA:RGD F phospholipid binding
GO:0007186 IMP:RGD P G-protein coupled receptor signaling pathway
GO:0000187 IEA:Ensembl P activation of MAPK activity
GO:0032060 IEA:Ensembl P bleb assembly
GO:0051928 IMP:RGD P positive regulation of calcium ion transport
GO:0048672 IEA:Ensembl P positive regulation of collateral sprouting
GO:0051482 IDA:RGD P positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954152 G alpha (i) signalling events
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5954244 Lysosphingolipid and LPA receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR004065 Lysophosphatidic acid receptor
IPR005385 Lysophosphatidic acid receptor EDG-7

UniProt Annotations

Entry Information

Gene Name
lysophosphatidic acid receptor 3
Protein Entry
LPAR3_RAT
UniProt ID
Q8K5E0
Species
Rat

Comments

Comment Type Description
Function Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins (By similarity)
Sequence Caution Sequence=AAG24262.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012735 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13095922 RefSeq NP_076459 345 lysophosphatidic acid receptor 3

Identical Sequences to LMP012735 proteins

Reference Database Accession Length Protein Name
GI:13095922 GenBank AAG24262.1 345 putative G protein-coupled receptor snGPCR32 [Rattus norvegicus]

Related Sequences to LMP012735 proteins

Reference Database Accession Length Protein Name
GI:13095922 GenBank AAG24262.1 345 putative G protein-coupled receptor snGPCR32 [Rattus norvegicus]
GI:13095922 RefSeq XP_008759744.1 354 PREDICTED: lysophosphatidic acid receptor 3 isoform X1 [Rattus norvegicus]
GI:13095922 RefSeq XP_008759745.1 354 PREDICTED: lysophosphatidic acid receptor 3 isoform X1 [Rattus norvegicus]