Gene/Proteome Database (LMPD)

LMPD ID
LMP012735
Gene ID
66025
Species
Rattus norvegicus (Rat)
Gene Name
lysophosphatidic acid receptor 3
Gene Symbol
Lpar3
Synonyms
Edg7;
Alternate Names
lysophosphatidic acid receptor 3; LPA-3; snGPCR32; LPA receptor 3; lysophosphatidic acid receptor Edg-7; putative G protein-coupled receptor snGPCR32; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7;
Chromosome
2
Map Location
2q44
Summary
G protein-coupled receptor for lysophosphatidic acid (LPA); may play a role in reproductive tissues [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Lpar3

Proteins

lysophosphatidic acid receptor 3
Refseq ID NP_076459
Protein GI 13095922
UniProt ID Q8K5E0
mRNA ID NM_023969
Length 345
MDFFYNRSNTDTADEWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVITNRKFHFPFYYLLANLAVADFFAGIAYVFLMFNTGPVSKTLTVNRWLLRQGLLDTSLTASLANLLVIAVERHMSIMRMRIHSNLTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLIFWTVSNLLAFFIMVVVYVRIYMYVKRKTNVLSPHTSGSISRRRAPMKLMKTVMTVLGAFVVCWTPGLVVLLLDGLNCKQCNVQHVKRWFLLLALLNSVMNPIIYSYKDEDMYNTMRKMICCAPHDSNAERHPSRIPSTIHSRSDTGSQYLEDSISQGQVCNKSSS

Gene Information

Entrez Gene ID
66025
Gene Name
lysophosphatidic acid receptor 3
Gene Symbol
Lpar3
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IEA:Ensembl C axon
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0001965 IMP:RGD F G-protein alpha-subunit binding
GO:0070915 IEA:InterPro F lysophosphatidic acid receptor activity
GO:0005543 IDA:RGD F phospholipid binding
GO:0000187 IEA:Ensembl P activation of MAPK activity
GO:0032060 IEA:Ensembl P bleb assembly
GO:0007186 IMP:RGD P G-protein coupled receptor signaling pathway
GO:0051928 IMP:RGD P positive regulation of calcium ion transport
GO:0048672 IEA:Ensembl P positive regulation of collateral sprouting
GO:0051482 IDA:RGD P positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

KEGG Pathway Links

KEGG Pathway ID Description
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction
ko04151 PI3K-Akt signaling pathway
rno04151 PI3K-Akt signaling pathway
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954152 G alpha (i) signalling events
5953653 G alpha (q) signalling events
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5954244 Lysosphingolipid and LPA receptors
5953391 Signaling by GPCR
5953381 Signal Transduction

Domain Information

InterPro Annotations

Accession Description
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR004065 Lysophosphatidic acid receptor
IPR005385 Lysophosphatidic acid receptor EDG-7

UniProt Annotations

Entry Information

Gene Name
lysophosphatidic acid receptor 3
Protein Entry
LPAR3_RAT
UniProt ID
Q8K5E0
Species
Rat

Comments

Comment Type Description
Function Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins (By similarity)
Sequence Caution Sequence=AAG24262.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012735 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13095922 RefSeq NP_076459 345 lysophosphatidic acid receptor 3

Identical Sequences to LMP012735 proteins

Reference Database Accession Length Protein Name
GI:13095922 GenBank AAG24262.1 345 putative G protein-coupled receptor snGPCR32 [Rattus norvegicus]

Related Sequences to LMP012735 proteins

Reference Database Accession Length Protein Name
GI:13095922 GenBank AAG24262.1 345 putative G protein-coupled receptor snGPCR32 [Rattus norvegicus]
GI:13095922 RefSeq XP_008759744.1 354 PREDICTED: lysophosphatidic acid receptor 3 isoform X1 [Rattus norvegicus]
GI:13095922 RefSeq XP_008759745.1 354 PREDICTED: lysophosphatidic acid receptor 3 isoform X1 [Rattus norvegicus]