Gene/Proteome Database (LMPD)
LMPD ID
LMP012738
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
solute carrier family 27 (fatty acid transporter), member 5
Gene Symbol
Synonyms
BAL; rBAL-1;
Alternate Names
bile acyl-CoA synthetase; BACS; FATP-5; VLACSR; BA-CoA ligase; VLACS-related; cholate--CoA ligase; bile acid CoA ligase; bile acid-CoA ligase; fatty acid transport protein 5; solute carrier family 27 member 5; very long-chain acyl-CoA synthetase-related protein;
Chromosome
1
Map Location
1q21
EC Number
6.2.1.7
Summary
catalyzes the first of two steps in the conjugation of bile acids with the amino acids glycine and taurine [RGD, Feb 2006]
Orthologs
Proteins
| bile acyl-CoA synthetase precursor | |
|---|---|
| Refseq ID | NP_077057 |
| Protein GI | 13162326 |
| UniProt ID | Q9ES38 |
| mRNA ID | NM_024143 |
| Length | 690 |
| MGVWKKLTFLLLSLLLLVGLGQPLWPAATALALRWFLGDPTCFVLLGLAFLGRPWISSWIPHWLSLAAAALTLSLLPPRPPPELRWLHKDVAFAFKLLFYGLNLRRRLNRHPPELFVDALEQQAQARPDQVALVCTGSEGCSITNRELNAKACQAAWALKAKLKEATIQEDKGATAILVLPSKSISALSVFLGLAKLGCPVAWINPHSRGMPLLHSVQSSGASVLIVDPDLQENLEEVLPKLLAENIRCFYLGHSSPTPGVEALGAALDAAPSDPVPAKLRANIKWKSPAIFIYTSGTTGLPKPAILSHERVIQMSNVLSFCGRTADDVVYNVLPLYHSMGLVLGVLGCLQLGATCVLAPKFSASRYWAECRQYSVTVVLYVGEVLRYLCNVPGQPEDKKHTVRFALGNGLRADVWENFQQRFGPIQIWELYGSTEGNVGLMNYVGHCGAVGKTSCFIRMLTPLELVQFDIETAEPVRDKQGFCIPVETGKPGLLLTKIRKNQPFLGYRGSQDETKRKLVANVRQVGDLYYNTGDVLALDQEGFFYFRDRLGDTFRWKGENVSTREVEGVLSILDFLEEVNVYGVTVPGCEGKVGMAAVKLAPGKTFDGQKLYQHVRSWLPAYATPHFIRIQDSLEITNTYKLVKSQLAREGFDVGVIADPLYILDNKAETFRSLMPDVYQAVCEGTWKL | |
| sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2315 peptide sequence: MGVWKKLTFLLLSLLLLVGLG | |
Gene Information
Entrez Gene ID
Gene Name
solute carrier family 27 (fatty acid transporter), member 5
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0009925 | IEA:Ensembl | C | basal plasma membrane |
| GO:0030176 | IEA:Ensembl | C | integral component of endoplasmic reticulum membrane |
| GO:0043231 | IDA:RGD | C | intracellular membrane-bounded organelle |
| GO:0043234 | IDA:RGD | C | protein complex |
| GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
| GO:0047747 | IDA:RGD | F | cholate-CoA ligase activity |
| GO:0015245 | IEA:Ensembl | F | fatty acid transporter activity |
| GO:0032403 | IDA:RGD | F | protein complex binding |
| GO:0031957 | IEA:Ensembl | F | very long-chain fatty acid-CoA ligase activity |
| GO:0006699 | IEA:Ensembl | P | bile acid biosynthetic process |
| GO:0008206 | IMP:RGD | P | bile acid metabolic process |
| GO:0046951 | IEA:Ensembl | P | ketone body biosynthetic process |
| GO:0015911 | IEA:Ensembl | P | plasma membrane long-chain fatty acid transport |
| GO:0006642 | IEA:Ensembl | P | triglyceride mobilization |
| GO:0000038 | IEA:Ensembl | P | very long-chain fatty acid metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko04976 | Bile secretion |
| rno04976 | Bile secretion |
| M00106 | Conjugated bile acid biosynthesis, cholate => taurocholate/glycocholate |
| rno01100 | Metabolic pathways |
| ko03320 | PPAR signaling pathway |
| rno03320 | PPAR signaling pathway |
| ko00120 | Primary bile acid biosynthesis |
| rno00120 | Primary bile acid biosynthesis |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY-6061 | bile acid biosynthesis, neutral pathway |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5953720 | Bile acid and bile salt metabolism |
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5953719 | Recycling of bile acids and salts |
| 5953930 | Synthesis of bile acids and bile salts |
| 5953933 | Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 5953931 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
Domain Information
UniProt Annotations
Entry Information
Gene Name
solute carrier family 27 (fatty acid transporter), member 5
Protein Entry
S27A5_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | ATP + (25R)-3-alpha,7-alpha,12-alpha- trihydroxy-5-beta-cholestan-26-oate + CoA = AMP + diphosphate + (25R)-3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA |
| Catalytic Activity | ATP + cholate + CoA = AMP + diphosphate + choloyl-CoA |
| Function | Acyl-CoA synthetase involved in bile acid metabolism. Proposed to catalyze the first step in the conjugation of C24 bile acids (choloneates) to glycine and taurine before excretion into bile canaliculi by activating them to their CoA thioesters. Seems to activate secondary bile acids entering the liver from the enterohepatic circulation. |
| Similarity | Belongs to the ATP-dependent AMP-binding enzyme family |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein . |
| Tissue Specificity | Predominantly expressed in liver (at protein level) |
Identical and Related Proteins
Unique RefSeq proteins for LMP012738 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 13162326 | RefSeq | NP_077057 | 690 | bile acyl-CoA synthetase precursor |
Identical Sequences to LMP012738 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13162326 | GenBank | AAG09770.1 | 690 | bile acid CoA ligase [Rattus norvegicus] |
| GI:13162326 | GenBank | AAH91147.1 | 690 | Solute carrier family 27 (fatty acid transporter), member 5 [Rattus norvegicus] |
| GI:13162326 | GenBank | EDL75770.1 | 690 | solute carrier family 27 (fatty acid transporter), member 5, isoform CRA_a [Rattus norvegicus] |
| GI:13162326 | SwissProt | Q9ES38.1 | 690 | RecName: Full=Bile acyl-CoA synthetase; Short=BACS; AltName: Full=Bile acid-CoA ligase; Short=BA-CoA ligase; Short=BAL; AltName: Full=Cholate--CoA ligase; AltName: Full=Fatty acid transport protein 5; Short=FATP-5; AltName: Full=Solute carrier family 27 member 5; AltName: Full=Very long-chain acyl-CoA synthetase-related protein; Short=VLACS-related; Short=VLACSR [Rattus norvegicus] |
Related Sequences to LMP012738 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:13162326 | GenBank | AAG09770.1 | 690 | bile acid CoA ligase [Rattus norvegicus] |
| GI:13162326 | GenBank | AAH91147.1 | 690 | Solute carrier family 27 (fatty acid transporter), member 5 [Rattus norvegicus] |
| GI:13162326 | GenBank | EDL75770.1 | 690 | solute carrier family 27 (fatty acid transporter), member 5, isoform CRA_a [Rattus norvegicus] |