Gene/Proteome Database (LMPD)

LMPD ID
LMP012739
Gene ID
79112
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class M
Gene Symbol
Pigm
Synonyms
GPI-MT-I;
Alternate Names
GPI mannosyltransferase 1; GPI mannosyltransferase I; PIG-M mRNA for mannosyltransferase; phosphatidylinositol glycan, class M; phosphatidylinositol-glycan biosynthesis class M protein;
Chromosome
13
Map Location
13q24
EC Number
2.4.1.-
Summary
mannosyltransferase that catalyzes the transfer of the first mannose to glycosylphosphatidylinositol in GPI anchor biosynthesis; activity may be localized to the lumenal side of the endoplasmic reticulum membrane [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pigm

Proteins

GPI mannosyltransferase 1
Refseq ID NP_077058
Protein GI 13162329
UniProt ID Q9EQY6
mRNA ID NM_024144
Length 423
MSYTKHWGEWFLNLRVPPAGVFGVAFLARVALVFYGVFQDRTLLVRYTDIDYHVFTDAARFVTEGRSPYLRATYRYTPLLSWLLTPNVYLSELFGKFLFISCDLLTAFLLYRLLLLKGLGRRQACGYCVFWLLNPLPMAVSSRGNADSIVASLVLTTLYLIEKRLIACAAVFYGFAVHMKMYPVTYILPIALHLRPERDSDEGLRLARYSFQARLYDFLKRLCSWAVLLFVAIAGLTFLALSFGFYYKYGWEFLEHTYLYHLTRRDIRHNFSPYFYMLYLTAESKWSFTLGIAAFLPQFILLSAASFAYYRDLVFCCFLHTSIFVTFNKVCTSQYFLWYLCLLPLVMPLVRMPWKRAVVLLMLWFIGQALWLAPAYVLEFQGKNTFLFIWLAGLFFLLINCSILIQIISHYKEDRLTERIKYD

Gene Information

Entrez Gene ID
79112
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class M
Gene Symbol
Pigm
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 IEA:InterPro C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0000030 IDA:RGD F mannosyltransferase activity
GO:0006506 IDA:RGD P GPI anchor biosynthetic process
GO:0097502 IDA:GOC P mannosylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
rno00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
M00065 GPI-anchor biosynthesis, core oligosaccharide
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5953345 Metabolism of proteins
5953735 Post-translational modification: synthesis of GPI-anchored proteins
5953728 Post-translational protein modification
5953734 Synthesis of glycosylphosphatidylinositol (GPI)

Domain Information

InterPro Annotations

Accession Description
IPR007704 Mannosyltransferase, DXD

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol glycan anchor biosynthesis, class M
Protein Entry
PIGM_RAT
UniProt ID
Q9EQY6
Species
Rat

Comments

Comment Type Description
Function Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity)
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Similarity Belongs to the PIGM family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012739 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13162329 RefSeq NP_077058 423 GPI mannosyltransferase 1

Identical Sequences to LMP012739 proteins

Reference Database Accession Length Protein Name
GI:13162329 DBBJ BAB18566.1 423 mannosyltransferase [Rattus norvegicus]
GI:13162329 GenBank EDL94711.1 423 phosphatidylinositol glycan, class M [Rattus norvegicus]
GI:13162329 RefSeq XP_008772129.1 423 PREDICTED: GPI mannosyltransferase 1 [Rattus norvegicus]
GI:13162329 SwissProt Q9EQY6.1 423 RecName: Full=GPI mannosyltransferase 1; AltName: Full=GPI mannosyltransferase I; Short=GPI-MT-I; AltName: Full=Phosphatidylinositol-glycan biosynthesis class M protein; Short=PIG-M [Rattus norvegicus]

Related Sequences to LMP012739 proteins

Reference Database Accession Length Protein Name
GI:13162329 GenBank EDL94711.1 423 phosphatidylinositol glycan, class M [Rattus norvegicus]
GI:13162329 RefSeq XP_008772129.1 423 PREDICTED: GPI mannosyltransferase 1 [Rattus norvegicus]
GI:13162329 SwissProt Q9EQY6.1 423 RecName: Full=GPI mannosyltransferase 1; AltName: Full=GPI mannosyltransferase I; Short=GPI-MT-I; AltName: Full=Phosphatidylinositol-glycan biosynthesis class M protein; Short=PIG-M [Rattus norvegicus]