Gene/Proteome Database (LMPD)

LMPD ID
LMP012740
Gene ID
79122
Species
Rattus norvegicus (Rat)
Gene Name
ferredoxin reductase
Gene Symbol
Fdxr
Synonyms
AR;
Alternate Names
NADPH:adrenodoxin oxidoreductase, mitochondrial; adrenodoxin reductase; ferredoxin--NADP(+) reductase;
Chromosome
10
Map Location
10q32.2
EC Number
1.18.1.6
Summary
component of electron transfer system for mitochondrial cytochromes P-450; mediates production of steroid hormones and bile acids; activates vitamin D3 in the steroidogenic tissues, liver and kidney [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Fdxr

Proteins

NADPH:adrenodoxin oxidoreductase, mitochondrial precursor
Refseq ID NP_077067
Protein GI 13162347
UniProt ID P56522
mRNA ID NM_024153
Length 494
MAPRCWRWWSWSAWPGVRPLPSRSTPTPGFCKKFSTQETTPQICVVGSGPAGFYTAQHLLKHHTRAHVDIYEKQLVPFGLVRFGVAPDHPEVKNVINTFTQTARSDRCAFRGNVVVGRDVSVPELREAYHAVVLSYGAEDHQPLEIPGEELPGVVSARAFVGWYNGLPENQKLAPDLSCDTAVILGQGNVALDVARILLTPPEHLEKTDITEVALGVLRQSRVKTVWIVGRRGPLQVAFTIKELREMIQLPGTQPILDPSDFLGLQDRIKDVPRPRKRLTELLLRTATEKPGVEEAARRALASRAWGLRFFRSPQQVLPTPDGRRVAGIRLAVTRLEGVGESTRAVPTGDVEDLPCGLLLSSVGYKSRPIDPSVPFDPKLGIIPNTEGRVVNAPGLYCSGWVKRGPTGVITTTMTDSFLTSQVLLKDLKAGLLPSGPRPGYTAIQALLSDRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDRREMLQLLGH
transit_peptide: 1..34 calculated_mol_wt: 4064 peptide sequence: MAPRCWRWWSWSAWPGVRPLPSRSTPTPGFCKKF mat_peptide: 35..494 product: NADPH:adrenodoxin oxidoreductase, mitochondrial calculated_mol_wt: 50317 peptide sequence: STQETTPQICVVGSGPAGFYTAQHLLKHHTRAHVDIYEKQLVPFGLVRFGVAPDHPEVKNVINTFTQTARSDRCAFRGNVVVGRDVSVPELREAYHAVVLSYGAEDHQPLEIPGEELPGVVSARAFVGWYNGLPENQKLAPDLSCDTAVILGQGNVALDVARILLTPPEHLEKTDITEVALGVLRQSRVKTVWIVGRRGPLQVAFTIKELREMIQLPGTQPILDPSDFLGLQDRIKDVPRPRKRLTELLLRTATEKPGVEEAARRALASRAWGLRFFRSPQQVLPTPDGRRVAGIRLAVTRLEGVGESTRAVPTGDVEDLPCGLLLSSVGYKSRPIDPSVPFDPKLGIIPNTEGRVVNAPGLYCSGWVKRGPTGVITTTMTDSFLTSQVLLKDLKAGLLPSGPRPGYTAIQALLSDRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLVDRREMLQLLGH

Gene Information

Entrez Gene ID
79122
Gene Name
ferredoxin reductase
Gene Symbol
Fdxr
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005743 IEA:Ensembl C mitochondrial inner membrane
GO:0005739 IDA:RGD C mitochondrion
GO:0015039 IDA:RGD F NADPH-adrenodoxin reductase activity
GO:0070402 IDA:RGD F NADPH binding
GO:0008203 IEA:UniProtKB-UniPathway P cholesterol metabolic process
GO:0070995 IDA:RGD P NADPH oxidation

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6076 1,25-dihydroxyvitamin D3 biosynthesis
PWY-6061 bile acid biosynthesis, neutral pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954578 Electron transport from NADPH to Ferredoxin
5953250 Metabolism
5954454 Mitochondrial iron-sulfur cluster biogenesis

Domain Information

InterPro Annotations

Accession Description
IPR021163 Adrenodoxin-NADP+ reductase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
ferredoxin reductase
Protein Entry
ADRO_RAT
UniProt ID
P56522
Species
Rat

Comments

Comment Type Description
Catalytic Activity 2 reduced adrenodoxin + NADP(+) = 2 oxidized adrenodoxin + NADPH.
Cofactor Name=FAD; Xref=ChEBI:CHEBI:57692;
Function Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
Pathway Steroid metabolism; cholesterol metabolism.
Similarity Belongs to the ferredoxin--NADP reductase type 1 family
Subcellular Location Mitochondrion matrix.
Subunit Monomer. Interacts directly with FDX1

Identical and Related Proteins

Unique RefSeq proteins for LMP012740 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13162347 RefSeq NP_077067 494 NADPH:adrenodoxin oxidoreductase, mitochondrial precursor

Identical Sequences to LMP012740 proteins

Reference Database Accession Length Protein Name
GI:13162347 DBBJ BAA23759.1 494 precursor for adrenodoxin reductase [Rattus norvegicus]
GI:13162347 GenBank AAH88844.1 494 Ferredoxin reductase [Rattus norvegicus]
GI:13162347 GenBank EDM06569.1 494 ferredoxin reductase [Rattus norvegicus]
GI:13162347 SwissProt P56522.1 494 RecName: Full=NADPH:adrenodoxin oxidoreductase, mitochondrial; Short=AR; Short=Adrenodoxin reductase; AltName: Full=Ferredoxin--NADP(+) reductase; Short=Ferredoxin reductase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012740 proteins

Reference Database Accession Length Protein Name
GI:13162347 DBBJ BAA23759.1 494 precursor for adrenodoxin reductase [Rattus norvegicus]
GI:13162347 GenBank AAH88844.1 494 Ferredoxin reductase [Rattus norvegicus]
GI:13162347 SwissProt P56522.1 494 RecName: Full=NADPH:adrenodoxin oxidoreductase, mitochondrial; Short=AR; Short=Adrenodoxin reductase; AltName: Full=Ferredoxin--NADP(+) reductase; Short=Ferredoxin reductase; Flags: Precursor [Rattus norvegicus]