Gene/Proteome Database (LMPD)

LMPD ID
LMP012744
Gene ID
79223
Species
Rattus norvegicus (Rat)
Gene Name
glycerol kinase
Gene Symbol
Gk
Synonyms
Gyk; ASTP;
Alternate Names
glycerol kinase; glycerokinase; ATP:glycerol 3-phosphotransferase; ATP-stimulated glucocorticoid-receptor translocaton promoter; ATP-stimulated glucocorticoid-receptor translocation promoter;
Chromosome
X
Map Location
Xq22
EC Number
2.7.1.30
Summary
cytosolic protein that increases nuclear binding of activated glucocorticoid receptor [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Gk

Proteins

glycerol kinase
Refseq ID NP_077357
Protein GI 158186653
UniProt ID Q63060
mRNA ID NM_024381
Length 524
MAAAKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILQSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKLTGEPLYNAVVWLDLRTQSTVEKLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVKKVQEAVEENRALFGTIDSWLIWSLTGGINGGVHCTDVTNASRTMLFNIHSLEWDKELCEFFGIPMEILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQDGQAKNTYGTGCFLLCNTGHKCVFSEHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKSSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSIGWVTTQSPESGIP

Gene Information

Entrez Gene ID
79223
Gene Name
glycerol kinase
Gene Symbol
Gk
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0005739 IDA:RGD C mitochondrion
GO:0005634 IDA:RGD C nucleus
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004370 IEA:UniProtKB-EC F glycerol kinase activity
GO:0042393 IDA:RGD F histone binding
GO:0019563 IEA:UniProtKB-UniPathway P glycerol catabolic process
GO:0006072 IEA:InterPro P glycerol-3-phosphate metabolic process
GO:0009409 IEP:RGD P response to cold
GO:0042493 IEP:RGD P response to drug
GO:0045471 IDA:RGD P response to ethanol
GO:0010033 IEP:RGD P response to organic substance

KEGG Pathway Links

KEGG Pathway ID Description
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
rno01100 Metabolic pathways
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953464 Triglyceride Biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR018485 Carbohydrate kinase, FGGY, C-terminal
IPR018484 Carbohydrate kinase, FGGY, N-terminal
IPR018483 Carbohydrate kinase, FGGY, conserved site
IPR005999 Glycerol kinase

UniProt Annotations

Entry Information

Gene Name
glycerol kinase
Protein Entry
GLPK_RAT
UniProt ID
Q63060
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + glycerol = ADP + sn-glycerol 3- phosphate.
Function Key enzyme in the regulation of glycerol uptake and metabolism (By similarity). Increases the binding of activated glucocorticoid-receptor to nuclei in the presence of ATP
Pathway Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
Similarity Belongs to the FGGY kinase family
Subcellular Location Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side {ECO:0000250}. Cytoplasm . Note=Bound to the mitochondrial surface or cytoplasmic

Identical and Related Proteins

Unique RefSeq proteins for LMP012744 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
158186653 RefSeq NP_077357 524 glycerol kinase

Identical Sequences to LMP012744 proteins

Reference Database Accession Length Protein Name

Related Sequences to LMP012744 proteins

Reference Database Accession Length Protein Name
GI:158186653 DBBJ BAA03677.1 524 ATP-stimulated glucocorticoid-receptor translocaton promoter [Rattus norvegicus]
GI:158186653 RefSeq XP_006257050.1 553 PREDICTED: glycerol kinase isoform X6 [Rattus norvegicus]
GI:158186653 SwissProt Q63060.1 524 RecName: Full=Glycerol kinase; Short=GK; Short=Glycerokinase; AltName: Full=ATP-stimulated glucocorticoid-receptor translocation promoter; Short=ASTP; AltName: Full=ATP:glycerol 3-phosphotransferase [Rattus norvegicus]