Gene/Proteome Database (LMPD)

LMPD ID
LMP012749
Gene ID
79244
Species
Rattus norvegicus (Rat)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 4
Gene Symbol
Hsd17b4
Synonyms
MPF-2;
Alternate Names
peroxisomal multifunctional enzyme type 2; DBP; MFE-2; 17-beta-HSD 4; D-bifunctional protein; multifunctional protein 2; 17-beta-hydroxysteroid dehydrogenase 4; peroxisomal multifunctional enzyme type II;
Chromosome
18
Map Location
18q11
Summary
a 17 beta-hydroxysteroid dehydrogenase type IV involved in cholesterol metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Hsd17b4

Proteins

peroxisomal multifunctional enzyme type 2
Refseq ID NP_077368
Protein GI 162287198
UniProt ID Q6IN39
mRNA ID NM_024392
Length 735
MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSSAADKVVEEIRRRGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSRISDEDWDIIQRVHLRGSFQVTRAAWDHMKKQNYGRIIMTASASGIYGNFGQANYSAAKLGLLGLANTLVIEGRKNNIHCNTIAPNAGSRMTETVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRKRNQPMTPEAVRDNWVKICDFSNASKPKSIQESTGGIIEVLHKIDSEGISQNHTGQVASADASGFAGVVGHKLPSFSSSYTELQCIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSLMSGGLAEVPGLSINFAKVLHGEQYLELYKPLPRSGELKCEAVIADILDKGSGIVIVMDVYSYSGKELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPSRPPDAVLRDTTSLNQAALYRLSGDSNPLHIDPSFASIAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLVPTSGVSAQTPSEGGALQSALVFGEIGRRLKDVGREVVKKVNAVFEWHITKNGNVAAKWTIDLKNGSGEVYQGPAKGSADTTITISDEDFMEVVLGKLNPQNAFFSGRLKARGNIMLSQKLQMILKDYAKL

Gene Information

Entrez Gene ID
79244
Gene Name
hydroxysteroid (17-beta) dehydrogenase 4
Gene Symbol
Hsd17b4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016491 IEA:InterPro F oxidoreductase activity

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko04146 Peroxisome
rno04146 Peroxisome
ko00120 Primary bile acid biosynthesis
rno00120 Primary bile acid biosynthesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6061 bile acid biosynthesis, neutral pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954181 Beta-oxidation of pristanoyl-CoA
5954188 Beta-oxidation of very long chain fatty acids
5953720 Bile acid and bile salt metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953470 Peroxisomal lipid metabolism
5953930 Synthesis of bile acids and bile salts
5953931 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
5954542 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
5954543 alpha-linolenic acid (ALA) metabolism

Domain Information

InterPro Annotations

Accession Description
IPR002347 Glucose/ribitol dehydrogenase
IPR029069 HotDog domain
IPR002539 MaoC-like domain
IPR016040 NAD(P)-binding domain
IPR003033 SCP2 sterol-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 4
Protein Entry
Q6IN39_RAT
UniProt ID
Q6IN39
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012749 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
162287198 RefSeq NP_077368 735 peroxisomal multifunctional enzyme type 2

Identical Sequences to LMP012749 proteins

Reference Database Accession Length Protein Name
GI:162287198 GenBank AAB49519.1 735 17 beta-hydroxysteroid dehydrogenase type IV [Rattus sp.]
GI:162287198 SwissProt P97852.3 735 RecName: Full=Peroxisomal multifunctional enzyme type 2; Short=MFE-2; AltName: Full=17-beta-hydroxysteroid dehydrogenase 4; Short=17-beta-HSD 4; AltName: Full=D-bifunctional protein; Short=DBP; AltName: Full=Multifunctional protein 2; Short=MPF-2; Contains: RecName: Full=(3R)-hydroxyacyl-CoA dehydrogenase; Contains: RecName: Full=Enoyl-CoA hydratase 2; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase [Rattus norvegicus]

Related Sequences to LMP012749 proteins

Reference Database Accession Length Protein Name
GI:162287198 GenBank AAB09724.1 735 peroxisomal multifunctional enzyme type II [Rattus norvegicus]
GI:162287198 GenBank AAB49519.1 735 17 beta-hydroxysteroid dehydrogenase type IV [Rattus sp.]
GI:162287198 SwissProt P97852.3 735 RecName: Full=Peroxisomal multifunctional enzyme type 2; Short=MFE-2; AltName: Full=17-beta-hydroxysteroid dehydrogenase 4; Short=17-beta-HSD 4; AltName: Full=D-bifunctional protein; Short=DBP; AltName: Full=Multifunctional protein 2; Short=MPF-2; Contains: RecName: Full=(3R)-hydroxyacyl-CoA dehydrogenase; Contains: RecName: Full=Enoyl-CoA hydratase 2; AltName: Full=3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase [Rattus norvegicus]