Gene/Proteome Database (LMPD)

LMPD ID
LMP012751
Gene ID
79250
Species
Rattus norvegicus (Rat)
Gene Name
aconitase 2, mitochondrial
Gene Symbol
Aco2
Alternate Names
aconitate hydratase, mitochondrial; citrate hydro-lyase; mitochondrial aconitase (nuclear aco2 gene);
Chromosome
7
Map Location
7q34
EC Number
4.2.1.3

Proteins

aconitate hydratase, mitochondrial precursor
Refseq ID NP_077374
Protein GI 40538860
UniProt ID Q9ER34
mRNA ID NM_024398
Length 780
MAPYSLLVTRLQKALGVRQYHVASALCQRAKVAMSHFEPSEYIRYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDHLIEAQLGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGTLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRADIANLAEEFKDHLVPDPGCQYDQVIEINLNELKPHINGPFTPDLAHPVADVGTVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPDADELPRSDFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPSDYNKIHPVDKLTIQGLKDFAPGKPLNCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ
transit_peptide: 1..27 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9ER34.2) calculated_mol_wt: 2990 peptide sequence: MAPYSLLVTRLQKALGVRQYHVASALC mat_peptide: 28..780 product: Aconitate hydratase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9ER34.2) calculated_mol_wt: 82462 peptide sequence: QRAKVAMSHFEPSEYIRYDLLEKNINIVRKRLNRPLTLSEKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQDATAQMAMLQFISSGLPKVAVPSTIHCDHLIEAQLGGEKDLRRAKDINQEVYNFLATAGAKYGVGFWRPGSGIIHQIILENYAYPGVLLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGTLSGWTSPKDVILKVAGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRADIANLAEEFKDHLVPDPGCQYDQVIEINLNELKPHINGPFTPDLAHPVADVGTVAEKEGWPLDIRVGLIGSCTNSSYEDMGRSAAVAKQALAHGLKCKSQFTITPGSEQIRATIERDGYAQILRDVGGIVLANACGPCIGQWDRKDIKKGEKNTIVTSYNRNFTGRNDANPETHAFVTSPEIVTALAIAGTLKFNPETDFLTGKDGKKFKLEAPDADELPRSDFDPGQDTYQHPPKDSSGQRVDVSPTSQRLQLLEPFDKWDGKDLEDLQILIKVKGKCTTDHISAAGPWLKFRGHLDNISNNLLIGAINIENGKANSVRNAVTQEFGPVPDTARYYKKHGIRWVVIGDENYGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTFADPSDYNKIHPVDKLTIQGLKDFAPGKPLNCIIKHPNGTQETILLNHTFNETQIEWFRAGSALNRMKELQQ

Gene Information

Entrez Gene ID
79250
Gene Name
aconitase 2, mitochondrial
Gene Symbol
Aco2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:RGD C mitochondrion
GO:0005634 IEA:Ensembl C nucleus
GO:0051538 IDA:RGD F 3 iron, 4 sulfur cluster binding
GO:0051539 IDA:RGD F 4 iron, 4 sulfur cluster binding
GO:0003994 IDA:RGD F aconitate hydratase activity
GO:0005506 IEA:Ensembl F iron ion binding
GO:0006101 IDA:RGD P citrate metabolic process
GO:0006102 IDA:RGD P isocitrate metabolic process
GO:0006099 IDA:RGD P tricarboxylic acid cycle

KEGG Pathway Links

KEGG Pathway ID Description
ko01210 2-Oxocarboxylic acid metabolism
rno01210 2-Oxocarboxylic acid metabolism
ko01230 Biosynthesis of amino acids
rno01230 Biosynthesis of amino acids
ko01200 Carbon metabolism
rno01200 Carbon metabolism
ko00020 Citrate cycle (TCA cycle)
rno00020 Citrate cycle (TCA cycle)
M00009 Citrate cycle (TCA cycle, Krebs cycle)
M00010 Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
ko00630 Glyoxylate and dicarboxylate metabolism
rno00630 Glyoxylate and dicarboxylate metabolism
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5953285 Citric acid cycle (TCA cycle)
5953250 Metabolism
5953269 Pyruvate metabolism and Citric Acid (TCA) cycle
5953270 The citric acid (TCA) cycle and respiratory electron transport

Domain Information

InterPro Annotations

Accession Description
IPR000573 Aconitase A/isopropylmalate dehydratase small subunit, swivel
IPR018136 Aconitase family, 4Fe-4S cluster binding site
IPR006248 Aconitase, mitochondrial-like
IPR001030 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha
IPR015931 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 1/3
IPR015932 Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, subdomain 2
IPR015928 Aconitase/3-isopropylmalate dehydratase, swivel
IPR015937 Aconitase/isopropylmalate dehydratase

UniProt Annotations

Entry Information

Gene Name
aconitase 2, mitochondrial
Protein Entry
ACON_RAT
UniProt ID
Q9ER34
Species
Rat

Comments

Comment Type Description
Catalytic Activity Citrate = isocitrate.
Cofactor Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence= ; Note=Binds 1 [4Fe-4S] cluster per subunit. Binding of a [3Fe-4S] cluster leads to an inactive enzyme. ;
Function Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Pathway Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.
Similarity Belongs to the aconitase/IPM isomerase family
Subcellular Location Mitochondrion .
Subunit Monomer

Identical and Related Proteins

Unique RefSeq proteins for LMP012751 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
40538860 RefSeq NP_077374 780 aconitate hydratase, mitochondrial precursor

Identical Sequences to LMP012751 proteins

Reference Database Accession Length Protein Name
GI:40538860 GenBank AAH61999.1 780 Aconitase 2, mitochondrial [Rattus norvegicus]
GI:40538860 GenBank EDM15697.1 780 aconitase 2, mitochondrial [Rattus norvegicus]
GI:40538860 SwissProt Q9ER34.2 780 RecName: Full=Aconitate hydratase, mitochondrial; Short=Aconitase; AltName: Full=Citrate hydro-lyase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012751 proteins

Reference Database Accession Length Protein Name
GI:40538860 GenBank AAH61999.1 780 Aconitase 2, mitochondrial [Rattus norvegicus]
GI:40538860 GenBank EDM15697.1 780 aconitase 2, mitochondrial [Rattus norvegicus]
GI:40538860 SwissProt Q9ER34.2 780 RecName: Full=Aconitate hydratase, mitochondrial; Short=Aconitase; AltName: Full=Citrate hydro-lyase; Flags: Precursor [Rattus norvegicus]