Gene/Proteome Database (LMPD)

LMPD ID
LMP012755
Gene ID
80849
Species
Rattus norvegicus (Rat)
Gene Name
inositol polyphosphate-4-phosphatase, type I
Gene Symbol
Inpp4a
Alternate Names
type I inositol 3,4-bisphosphate 4-phosphatase; inositol polyphosphate 4-phosphatase type I; inositol polyphosphate-4-phosphatase, type 1; type I inositol-3,4-bisphosphate 4-phosphatase; inositol polyphosphate-4-phosphatase, type I, 107kD;
Chromosome
9
Map Location
9q21
EC Number
3.1.3.66
Summary
enzyme that catalyzes the hydrolysis of the 4-position phosphate of inositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and phosphatidylinositol 3,4-bisphosphate [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Inpp4a

Proteins

type I inositol 3,4-bisphosphate 4-phosphatase
Refseq ID NP_112264
Protein GI 215272386
UniProt ID Q62784
mRNA ID NM_031002
Length 939
MTAREHSPRHGARARAMQRASTIDVTADMVGLSLAGNIQDPDEPILEFSLACSELHTPSLDRKPNSFVAVSVTTPPQAFWTKHAQTEIIEGTNNPIFLSSIAFFQDSLINQMTQIKLSVYDVKDRSQGTMYLLGSGTFVVKDLLQDRHHRLHLTLRSAESDRVGNITVIGWQMEEKSDQQPPVTRSLDTVNGRMVLPVDESLTEALGIRSKYASLRKDSLLKAVFGGAICRMYRFPTTDGNHLRILEQMAESVLSLHVPRQFVKLLLEEDAARVCELEELGELSPCWESLRRQIVTQYQTIILTYQENLTDLHQYKGPSFKASSLKADKKLEFVPTNLHIQRMRVQDDGGSDQNYDVVTIGAPAAHCQGFKSGGLRKKLHKFEEAKKHSFEECCTSSTCQSIIYIPQDVVRAKEIIAQINTLKTQVSYYAERLSRAAKDRSATGLERTLAILADKTRQLVTVCDCKLLANSIHGLNAARPDYIASKASPTSTEEEQVMLRNDQDTLMARWAGRSSRSSLQVDWHEEEWEKVWLNVDKSLECIIQRVDKLLQKERLHGEGGEDVFPCSSTCSSKKDCSPPPEESCPGEWSEALYPLLTTLTDCVAMMSDKAKAAMVFLLMQTAAPTIASYLSLQYRRDVVFCQTLTALICGFIIKLRNCLHDGGFLRQLYTIGLLAQFESLLSTYGEELAMLEDMSLGIMDLRNVTFKVTQATSNASSDMLPVITGNRDGFNVRIPLPGPLFDSLPREIQSGMLLRVQPVLFNVGINEQQTLAERFGDTSLQEVINVESLVRLNSYFEQFKEVLPEDCLPRSRSQTCLPELLRFLGQNVHARKNKNVDILWQAAEVCRRLNGVRFTSCKSAKDRTAMSVTLEQCLILQHEHGMAPQVFTQALECMRSEGCRRENTMKNVGSRKYAFNSLQLKAFPKHYRPPEGTYGKVET

Gene Information

Entrez Gene ID
80849
Gene Name
inositol polyphosphate-4-phosphatase, type I
Gene Symbol
Inpp4a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016316 TAS:RGD F phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:0034597 IEA:UniProtKB-EC F phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
GO:0036092 TAS:GOC P phosphatidylinositol-3-phosphate biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00131 Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositol
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate-4-phosphatase, type I
Protein Entry
INP4A_RAT
UniProt ID
Q62784
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha1; IsoId=Q62784-1; Sequence=Displayed; Name=2; Synonyms=Alpha2; IsoId=Q62784-2; Sequence=VSP_015247;
Catalytic Activity 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate.
Function Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate.
Pathway Signal transduction; phosphatidylinositol signaling pathway.
Similarity Belongs to the inositol 3,4-bisphosphate 4-phosphatase family
Similarity Contains 1 C2 domain
Tissue Specificity Widely expressed. Expressed at highest levels in the brain, heart and skeletal muscle

Identical and Related Proteins

Unique RefSeq proteins for LMP012755 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
215272386 RefSeq NP_112264 939 type I inositol 3,4-bisphosphate 4-phosphatase

Identical Sequences to LMP012755 proteins

Reference Database Accession Length Protein Name
GI:215272386 GenBank AAB01069.1 939 inositol polyphosphate 4-phosphatase [Rattus norvegicus]
GI:215272386 SwissProt Q62784.1 939 RecName: Full=Type I inositol 3,4-bisphosphate 4-phosphatase; AltName: Full=Inositol polyphosphate 4-phosphatase type I [Rattus norvegicus]

Related Sequences to LMP012755 proteins

Reference Database Accession Length Protein Name
GI:215272386 GenBank AAB01069.1 939 inositol polyphosphate 4-phosphatase [Rattus norvegicus]
GI:215272386 RefSeq NP_084542.2 939 type I inositol 3,4-bisphosphate 4-phosphatase isoform 1 [Mus musculus]
GI:215272386 SwissProt Q62784.1 939 RecName: Full=Type I inositol 3,4-bisphosphate 4-phosphatase; AltName: Full=Inositol polyphosphate 4-phosphatase type I [Rattus norvegicus]