Gene/Proteome Database (LMPD)

LMPD ID
LMP012756
Gene ID
81506
Species
Rattus norvegicus (Rat)
Gene Name
bone marrow stromal cell antigen 1
Gene Symbol
Bst1
Alternate Names
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; BST-1; cADPr hydrolase 2; ADP-ribosyl cyclase 2; bone marrow stromal antigen 1; cyclic ADP-ribose hydrolase 2;
Chromosome
14
Map Location
14q21
EC Number
3.2.2.6
Summary
expressed in pancreatic islet cells [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Bst1

Proteins

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor
Refseq ID NP_110475
Protein GI 13540658
UniProt ID Q63072
mRNA ID NM_030848
Length 319
MAVQACALSLRLGLWMSLLLPVLPGAGARAAGARWSGEGTTPHLQSIFLGRCAEYTTLLSLEPGNKNCTAIWEAFKVVLDKDPCSVLPSDYDLFINLSRHAIPRDKSLFWENNHLLVMSYAENTRRLMPLCDVLYGKVGDFLSWCRQENASGLDYQSCPTAEDCENNAVDAYWKSASMQYSRDSSGVINVMLNGSEPKGAYPTKGFFADFEIPYLQKDKITRIEIWVMHEVGGPHVESCGEGSVKILEDRLEALGFQHSCINDYPPVKFLMCVDHSTHPDCAMNSASASMWRESPALHAIGDISLIISLLVALASSSQA
sig_peptide: 1..27 calculated_mol_wt: 2781 peptide sequence: MAVQACALSLRLGLWMSLLLPVLPGAG mat_peptide: 28..294 product: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q63072.1) calculated_mol_wt: 29925 peptide sequence: ARAAGARWSGEGTTPHLQSIFLGRCAEYTTLLSLEPGNKNCTAIWEAFKVVLDKDPCSVLPSDYDLFINLSRHAIPRDKSLFWENNHLLVMSYAENTRRLMPLCDVLYGKVGDFLSWCRQENASGLDYQSCPTAEDCENNAVDAYWKSASMQYSRDSSGVINVMLNGSEPKGAYPTKGFFADFEIPYLQKDKITRIEIWVMHEVGGPHVESCGEGSVKILEDRLEALGFQHSCINDYPPVKFLMCVDHSTHPDCAMNSASASMWRES

Gene Information

Entrez Gene ID
81506
Gene Name
bone marrow stromal cell antigen 1
Gene Symbol
Bst1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031225 IEA:UniProtKB-KW C anchored component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0050135 IEA:UniProtKB-EC F NAD(P)+ nucleosidase activity
GO:0003953 IEA:InterPro F NAD+ nucleosidase activity
GO:0016740 IEA:UniProtKB-KW F transferase activity

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00760 Nicotinate and nicotinamide metabolism
rno00760 Nicotinate and nicotinamide metabolism
ko04972 Pancreatic secretion
rno04972 Pancreatic secretion
ko04970 Salivary secretion
rno04970 Salivary secretion

Domain Information

InterPro Annotations

Accession Description
IPR003193 ADP-ribosyl_cyclase
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
bone marrow stromal cell antigen 1
Protein Entry
BST1_RAT
UniProt ID
Q63072
Species
Rat

Comments

Comment Type Description
Catalytic Activity NAD(+) + H(2)O = ADP-D-ribose + nicotinamide.
Function Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger that elicits calcium release from intracellular stores. May be involved in pre-B-cell growth.
Similarity Belongs to the ADP-ribosyl cyclase family
Subcellular Location Cell membrane; Lipid-anchor, GPI-anchor.
Subunit Homodimer
Tissue Specificity Pancreatic islets, kidney, spleen, heart, thymus, intestine and salivary gland.

Identical and Related Proteins

Unique RefSeq proteins for LMP012756 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13540658 RefSeq NP_110475 319 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2 precursor

Identical Sequences to LMP012756 proteins

Reference Database Accession Length Protein Name
GI:13540658 DBBJ BAA08710.1 319 rat bone marrow stromal cell antigen 1 (BST-1) [Rattus norvegicus]
GI:13540658 GenBank EDL99954.1 319 rCG35975 [Rattus norvegicus]
GI:13540658 SwissProt Q63072.1 319 RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; AltName: Full=ADP-ribosyl cyclase 2; AltName: Full=Bone marrow stromal antigen 1; Short=BST-1; AltName: Full=Cyclic ADP-ribose hydrolase 2; Short=cADPr hydrolase 2; AltName: CD_antigen=CD157; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012756 proteins

Reference Database Accession Length Protein Name
GI:13540658 DBBJ BAA08710.1 319 rat bone marrow stromal cell antigen 1 (BST-1) [Rattus norvegicus]
GI:13540658 GenBank EDL99954.1 319 rCG35975 [Rattus norvegicus]
GI:13540658 SwissProt Q63072.1 319 RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2; AltName: Full=ADP-ribosyl cyclase 2; AltName: Full=Bone marrow stromal antigen 1; Short=BST-1; AltName: Full=Cyclic ADP-ribose hydrolase 2; Short=cADPr hydrolase 2; AltName: CD_antigen=CD157; Flags: Precursor [Rattus norvegicus]