Gene/Proteome Database (LMPD)

LMPD ID
LMP012761
Gene ID
81677
Species
Rattus norvegicus (Rat)
Gene Name
inositol-trisphosphate 3-kinase A
Gene Symbol
Itpka
Alternate Names
inositol-trisphosphate 3-kinase A; IP3K A; IP3 3-kinase A; insP 3-kinase A; inositol 145-triphosphate 3-kinase; inositol 1,4,5-triphosphate 3-kinase; inositol 1,4,5-trisphosphate 3-kinase A;
Chromosome
3
Map Location
3q35
EC Number
2.7.1.127
Summary
an enzyme that catalyses the phosphorylation of InsP3 to inositol 1,3,4,5-tetrakisphosphate (InsP4) [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Itpka

Proteins

inositol-trisphosphate 3-kinase A
Refseq ID NP_112307
Protein GI 399498521
UniProt ID P17105
mRNA ID NM_031045
Length 459
MTLPGHPTGMARPRGAGPCSPGLERAPRRSVGELRLLFEARCAAVAAAAAAGEPRARGAKRRGGQVPNGLPRAAPAPVIPQLTVTSEEDVAPASPGPPDREGNWLPAAGSHLQQPRRLSTSSLSSTGSSSLLEDSEDDLLSDSESRSRGNVQLETSEDVGQKSHWQKIRTMVNLPVMSPFKKRYSWVQLAGHTGSFKAAGTSGLILKRSSEPEHYCLVRLMADVLRGCVPAFHGVVERDGESYLQLQDLLDGFDGPCVLDCKMGVRTYLEEELTKARERPKLRKDMYKKMLAVDPEAPTEEEHAQRAVTKPRYMQWREGISSSTTLGFRIEGIKKADGSCSTDFKTTRSREQVTRVFEEFMQGDAEVLKRYLNRLQQIRDTLEISDFFRRHEVIGSSLLFVHDHCHRAGVWLIDFGKTTPLPDGQILDHRRPWEEGNREDGYLLGLDNLIGILANLAER

Gene Information

Entrez Gene ID
81677
Gene Name
inositol-trisphosphate 3-kinase A
Gene Symbol
Itpka
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043197 IDA:MGI C dendritic spine
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004683 IDA:RGD F calmodulin-dependent protein kinase activity
GO:0008440 IDA:RGD F inositol-1,4,5-trisphosphate 3-kinase activity
GO:0048365 IDA:MGI F Rac GTPase binding
GO:0030036 IMP:MGI P actin cytoskeleton organization
GO:0097062 IMP:MGI P dendritic spine maintenance
GO:0006020 IEA:Ensembl P inositol metabolic process
GO:0061003 IMP:MGI P positive regulation of dendritic spine morphogenesis
GO:0006468 IDA:GOC P protein phosphorylation
GO:0048167 IEA:Ensembl P regulation of synaptic plasticity

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

REACTOME Pathway Links

REACTOME Pathway ID Description
5954515 Inositol phosphate metabolism
5953250 Metabolism
5954514 Synthesis of IP3 and IP4 in the cytosol

Domain Information

InterPro Annotations

Accession Description
IPR005522 Inositol polyphosphate kinase

UniProt Annotations

Entry Information

Gene Name
inositol-trisphosphate 3-kinase A
Protein Entry
IP3KA_RAT
UniProt ID
P17105
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate
Enzyme Regulation IP3K is activated by calmodulin.
Sequence Caution Sequence=AAA41457.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the inositol phosphokinase (IPK) family

Identical and Related Proteins

Unique RefSeq proteins for LMP012761 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
399498521 RefSeq NP_112307 459 inositol-trisphosphate 3-kinase A

Identical Sequences to LMP012761 proteins

Reference Database Accession Length Protein Name
GI:399498521 EMBL CAA40248.1 459 inositol 1,4,5-triphosphate 3-kinase [Rattus norvegicus]
GI:399498521 GenBank EDL79924.1 459 inositol 1,4,5-trisphosphate 3-kinase A, isoform CRA_b [Rattus norvegicus]
GI:399498521 SwissProt P17105.3 459 RecName: Full=Inositol-trisphosphate 3-kinase A; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase A; Short=IP3 3-kinase A; Short=IP3K A; Short=InsP 3-kinase A [Rattus norvegicus]

Related Sequences to LMP012761 proteins

Reference Database Accession Length Protein Name
GI:399498521 EMBL CAA40248.1 459 inositol 1,4,5-triphosphate 3-kinase [Rattus norvegicus]
GI:399498521 GenBank EDL79924.1 459 inositol 1,4,5-trisphosphate 3-kinase A, isoform CRA_b [Rattus norvegicus]
GI:399498521 SwissProt P17105.3 459 RecName: Full=Inositol-trisphosphate 3-kinase A; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase A; Short=IP3 3-kinase A; Short=IP3K A; Short=InsP 3-kinase A [Rattus norvegicus]