Gene/Proteome Database (LMPD)

LMPD ID
LMP012764
Gene ID
81726
Species
Rattus norvegicus (Rat)
Gene Name
mevalonate (diphospho) decarboxylase
Gene Symbol
Mvd
Synonyms
Mvpd;
Alternate Names
diphosphomevalonate decarboxylase; MDDase; mevalonate pyrophosphate decarboxylase;
Chromosome
19
Map Location
19q12
EC Number
4.1.1.33
Summary
enzyme that catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate; involved in cholesterol biosynthesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Mvd

Proteins

diphosphomevalonate decarboxylase
Refseq ID NP_112324
Protein GI 13592005
UniProt ID Q62967
mRNA ID NM_031062
Length 401
MASEKPQDLMVTCTAPVNIAVIKYWGKRDEALILPINPSLSVTLHQDQLKTTTTAAISKDFTEDRIWLNGREEDVGQPRLQACLREIRRLARKRRSTGDGDALPLSLGYKVHVASVNNFPTAAGLASSAAGYACLAYTLARVYGVEGDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQIAPEWHWPQLRVLILVVSAEKKPTGSTVGMQTSVATSTLLKFRAESIVPERMKEMTRCIQEQDFQAFAQLTMKDSNQFHATCLDTFPPISYLNDTSRRIIQLVHRFNAHHGQTKVAYTFDAGPNAVIFTLEDTVAEFVAAVRHSFPPAANGDKFLKGLQVAPVLLSDELKTSLATEPSPGGVQYIIATQVGPGPQVLDDPHHHLLGPDGLPQRDL

Gene Information

Entrez Gene ID
81726
Gene Name
mevalonate (diphospho) decarboxylase
Gene Symbol
Mvd
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0005782 IDA:RGD C peroxisomal matrix
GO:0005777 IDA:RGD C peroxisome
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004163 IDA:RGD F diphosphomevalonate decarboxylase activity
GO:0006695 NAS:RGD P cholesterol biosynthetic process
GO:0019287 IDA:RGD P isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:0042493 IEP:RGD P response to drug

KEGG Pathway Links

KEGG Pathway ID Description
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
rno01100 Metabolic pathways
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5954496 Activation of gene expression by SREBF (SREBP)
5953739 Asparagine N-linked glycosylation
5953738 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
5953924 Cholesterol biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953345 Metabolism of proteins
5953728 Post-translational protein modification
5954497 Regulation of cholesterol biosynthesis by SREBP (SREBF)
5953925 Synthesis of Dolichyl-phosphate
5953737 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR029765 Diphosphomevalonate decarboxylase
IPR005935 Diphosphomevalonate/phosphomevalonate decarboxylase
IPR006204 GHMP kinase N-terminal domain
IPR013750 GHMP kinase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR014721 Ribosomal protein S5 domain 2-type fold, subgroup

UniProt Annotations

Entry Information

Gene Name
mevalonate (diphospho) decarboxylase
Protein Entry
MVD1_RAT
UniProt ID
Q62967
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2).
Function Performs the first committed step in the biosynthesis of isoprenes.
Pathway Steroid biosynthesis; cholesterol biosynthesis.
Similarity Belongs to the diphosphomevalonate decarboxylase family
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP012764 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13592005 RefSeq NP_112324 401 diphosphomevalonate decarboxylase

Identical Sequences to LMP012764 proteins

Reference Database Accession Length Protein Name
GI:13592005 GenBank AAB00192.1 401 mevalonate pyrophosphate decarboxylase [Rattus norvegicus]
GI:13592005 SwissProt Q62967.1 401 RecName: Full=Diphosphomevalonate decarboxylase; AltName: Full=Mevalonate (diphospho)decarboxylase; Short=MDDase; AltName: Full=Mevalonate pyrophosphate decarboxylase [Rattus norvegicus]

Related Sequences to LMP012764 proteins

Reference Database Accession Length Protein Name
GI:13592005 GenBank AAB00192.1 401 mevalonate pyrophosphate decarboxylase [Rattus norvegicus]
GI:13592005 GenBank EDL92747.1 401 mevalonate (diphospho) decarboxylase [Rattus norvegicus]
GI:13592005 SwissProt Q62967.1 401 RecName: Full=Diphosphomevalonate decarboxylase; AltName: Full=Mevalonate (diphospho)decarboxylase; Short=MDDase; AltName: Full=Mevalonate pyrophosphate decarboxylase [Rattus norvegicus]