Gene/Proteome Database (LMPD)
LMPD ID
LMP012764
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
mevalonate (diphospho) decarboxylase
Gene Symbol
Synonyms
Mvpd;
Alternate Names
diphosphomevalonate decarboxylase; MDDase; mevalonate pyrophosphate decarboxylase;
Chromosome
19
Map Location
19q12
EC Number
4.1.1.33
Summary
enzyme that catalyzes the conversion of mevalonate pyrophosphate into isopentenyl pyrophosphate; involved in cholesterol biosynthesis [RGD, Feb 2006]
Orthologs
Proteins
diphosphomevalonate decarboxylase | |
---|---|
Refseq ID | NP_112324 |
Protein GI | 13592005 |
UniProt ID | Q62967 |
mRNA ID | NM_031062 |
Length | 401 |
MASEKPQDLMVTCTAPVNIAVIKYWGKRDEALILPINPSLSVTLHQDQLKTTTTAAISKDFTEDRIWLNGREEDVGQPRLQACLREIRRLARKRRSTGDGDALPLSLGYKVHVASVNNFPTAAGLASSAAGYACLAYTLARVYGVEGDLSEVARRGSGSACRSLYGGFVEWQMGEQADGKDSIARQIAPEWHWPQLRVLILVVSAEKKPTGSTVGMQTSVATSTLLKFRAESIVPERMKEMTRCIQEQDFQAFAQLTMKDSNQFHATCLDTFPPISYLNDTSRRIIQLVHRFNAHHGQTKVAYTFDAGPNAVIFTLEDTVAEFVAAVRHSFPPAANGDKFLKGLQVAPVLLSDELKTSLATEPSPGGVQYIIATQVGPGPQVLDDPHHHLLGPDGLPQRDL |
Gene Information
Entrez Gene ID
Gene Name
mevalonate (diphospho) decarboxylase
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005829 | IDA:RGD | C | cytosol |
GO:0005782 | IDA:RGD | C | peroxisomal matrix |
GO:0005777 | IDA:RGD | C | peroxisome |
GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
GO:0004163 | IDA:RGD | F | diphosphomevalonate decarboxylase activity |
GO:0006695 | NAS:RGD | P | cholesterol biosynthetic process |
GO:0019287 | IDA:RGD | P | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
GO:0042493 | IEP:RGD | P | response to drug |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
M00095 | C5 isoprenoid biosynthesis, mevalonate pathway |
rno01100 | Metabolic pathways |
ko00900 | Terpenoid backbone biosynthesis |
rno00900 | Terpenoid backbone biosynthesis |
REACTOME Pathway Links
REACTOME Pathway ID | Description |
---|---|
5954496 | Activation of gene expression by SREBF (SREBP) |
5953739 | Asparagine N-linked glycosylation |
5953738 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
5953924 | Cholesterol biosynthesis |
5953250 | Metabolism |
5953289 | Metabolism of lipids and lipoproteins |
5953345 | Metabolism of proteins |
5953728 | Post-translational protein modification |
5954497 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
5953925 | Synthesis of Dolichyl-phosphate |
5953737 | Synthesis of substrates in N-glycan biosythesis |
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR029765 | Diphosphomevalonate decarboxylase |
IPR005935 | Diphosphomevalonate/phosphomevalonate decarboxylase |
IPR006204 | GHMP kinase N-terminal domain |
IPR013750 | GHMP kinase, C-terminal domain |
IPR020568 | Ribosomal protein S5 domain 2-type fold |
IPR014721 | Ribosomal protein S5 domain 2-type fold, subgroup |
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Catalytic Activity | ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO(2). |
Function | Performs the first committed step in the biosynthesis of isoprenes. |
Pathway | Steroid biosynthesis; cholesterol biosynthesis. |
Similarity | Belongs to the diphosphomevalonate decarboxylase family |
Subunit | Homodimer |
Identical and Related Proteins
Unique RefSeq proteins for LMP012764 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
13592005 | RefSeq | NP_112324 | 401 | diphosphomevalonate decarboxylase |
Identical Sequences to LMP012764 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:13592005 | GenBank | AAB00192.1 | 401 | mevalonate pyrophosphate decarboxylase [Rattus norvegicus] |
GI:13592005 | SwissProt | Q62967.1 | 401 | RecName: Full=Diphosphomevalonate decarboxylase; AltName: Full=Mevalonate (diphospho)decarboxylase; Short=MDDase; AltName: Full=Mevalonate pyrophosphate decarboxylase [Rattus norvegicus] |
Related Sequences to LMP012764 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:13592005 | GenBank | AAB00192.1 | 401 | mevalonate pyrophosphate decarboxylase [Rattus norvegicus] |
GI:13592005 | GenBank | EDL92747.1 | 401 | mevalonate (diphospho) decarboxylase [Rattus norvegicus] |
GI:13592005 | SwissProt | Q62967.1 | 401 | RecName: Full=Diphosphomevalonate decarboxylase; AltName: Full=Mevalonate (diphospho)decarboxylase; Short=MDDase; AltName: Full=Mevalonate pyrophosphate decarboxylase [Rattus norvegicus] |