Gene/Proteome Database (LMPD)
LMPD ID
LMP012774
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
diacylglycerol kinase zeta
Gene Symbol
Alternate Names
diacylglycerol kinase zeta; DGK-IV; DGK-zeta; DAG kinase zeta; diglyceride kinase zeta; 104 kDa diacylglycerol kinase;
Chromosome
3
Map Location
3q24
EC Number
2.7.1.107
Summary
catalyzes the conversion of diacylglycerol to phosphatidic acid [RGD, Feb 2006]
Orthologs
Proteins
diacylglycerol kinase zeta | |
---|---|
Refseq ID | NP_112405 |
Protein GI | 13592131 |
UniProt ID | O08560 |
mRNA ID | NM_031143 |
Length | 929 |
MEPRDPSPEARSSDSESASASSSGSERDADPEPDKAPRRLTKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCGESERQIRSTVDWSESAAYGEHIWFETNVSGDFCYVGEQYCVAKMLPKSAPRRKCAACKIVVHTPCIGQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMLQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLAASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQQEPDGAGAKSPMCHPLSSKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSLQGDAALPQGEELIEAAKRNDFCKLQELHRAGGDLMHRDHQSRTLLHHAVSTGSKEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDQQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV |
Gene Information
Entrez Gene ID
Gene Name
diacylglycerol kinase zeta
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005737 | IEA:UniProtKB-KW | C | cytoplasm |
GO:0030027 | IEA:Ensembl | C | lamellipodium |
GO:0005634 | IDA:RGD | C | nucleus |
GO:0005886 | IEA:UniProtKB-KW | C | plasma membrane |
GO:0005524 | IEA:UniProtKB-KW | F | ATP binding |
GO:0004143 | IDA:RGD | F | diacylglycerol kinase activity |
GO:0004857 | IEA:Ensembl | F | enzyme inhibitor activity |
GO:0001727 | IEA:Ensembl | F | lipid kinase activity |
GO:0046872 | IEA:UniProtKB-KW | F | metal ion binding |
GO:0003951 | IEA:InterPro | F | NAD+ kinase activity |
GO:0035556 | IEA:InterPro | P | intracellular signal transduction |
GO:0031571 | IEA:Ensembl | P | mitotic G1 DNA damage checkpoint |
GO:0045930 | IEA:Ensembl | P | negative regulation of mitotic cell cycle |
GO:0046580 | IEA:Ensembl | P | negative regulation of Ras protein signal transduction |
GO:0007205 | IEA:InterPro | P | protein kinase C-activating G-protein coupled receptor signaling pathway |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
ko00561 | Glycerolipid metabolism |
rno00561 | Glycerolipid metabolism |
ko00564 | Glycerophospholipid metabolism |
rno00564 | Glycerophospholipid metabolism |
rno01100 | Metabolic pathways |
ko04070 | Phosphatidylinositol signaling system |
rno04070 | Phosphatidylinositol signaling system |
REACTOME Pathway Links
REACTOME Pathway ID | Description |
---|---|
5953655 | Effects of PIP2 hydrolysis |
5953653 | G alpha (q) signalling events |
5953537 | Gastrin-CREB signalling pathway via PKC and MAPK |
5953642 | GPCR downstream signaling |
5953645 | Hemostasis |
5953644 | Platelet activation, signaling and aggregation |
5953391 | Signaling by GPCR |
5953381 | Signal Transduction |
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR002110 | Ankyrin repeat |
IPR020683 | Ankyrin repeat-containing domain |
IPR016064 | ATP-NAD kinase-like domain |
IPR000756 | Diacylglycerol kinase, accessory domain |
IPR001206 | Diacylglycerol kinase, catalytic domain |
IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Catalytic Activity | ATP + 1,2-diacyl-sn-glycerol = ADP + 1,2- diacyl-sn-glycerol 3-phosphate. |
Function | Displays a strong preference for 1,2-diacylglycerols over 1,3-diacylglycerols, but lacks substrate specificity among molecular species of long chain diacylglycerols. Regulates RASGRP1 activity (By similarity) |
Interaction | Q62696:Dlg1; NbExp=4; IntAct=EBI-8570505, EBI-389325; Q63622:Dlg2; NbExp=4; IntAct=EBI-8570505, EBI-396947; Q62936:Dlg3; NbExp=4; IntAct=EBI-8570505, EBI-349596; P31016:Dlg4; NbExp=6; IntAct=EBI-8570505, EBI-375655; |
Similarity | Belongs to the eukaryotic diacylglycerol kinase family |
Similarity | Contains 1 DAGKc domain. {ECO:0000255|PROSITE- ProRule:PRU00783}. |
Similarity | Contains 2 ANK repeats. {ECO:0000255|PROSITE- ProRule:PRU00023}. |
Similarity | Contains 2 phorbol-ester/DAG-type zinc fingers |
Subcellular Location | Cytoplasm . Nucleus {ECO:0000269|PubMed:8855332}. Cell membrane . |
Subunit | Interacts with the PDZ domain of the syntrophin SNTG1 and that of SNX27. Forms a signaling complex with RASGRP1 and HRAS (By similarity) |
Identical and Related Proteins
Unique RefSeq proteins for LMP012774 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
13592131 | RefSeq | NP_112405 | 929 | diacylglycerol kinase zeta |
Identical Sequences to LMP012774 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:13592131 | DBBJ | BAA18942.1 | 929 | diacylglycerol kinase [Rattus norvegicus] |
GI:13592131 | GenBank | EDL79551.1 | 929 | diacylglycerol kinase zeta, isoform CRA_a [Rattus norvegicus] |
GI:13592131 | GenBank | EDL79552.1 | 929 | diacylglycerol kinase zeta, isoform CRA_a [Rattus norvegicus] |
GI:13592131 | SwissProt | O08560.1 | 929 | RecName: Full=Diacylglycerol kinase zeta; Short=DAG kinase zeta; AltName: Full=104 kDa diacylglycerol kinase; AltName: Full=DGK-IV; AltName: Full=Diglyceride kinase zeta; Short=DGK-zeta [Rattus norvegicus] |
Related Sequences to LMP012774 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:13592131 | DBBJ | BAA18942.1 | 929 | diacylglycerol kinase [Rattus norvegicus] |
GI:13592131 | GenBank | EDL79551.1 | 929 | diacylglycerol kinase zeta, isoform CRA_a [Rattus norvegicus] |
GI:13592131 | SwissProt | O08560.1 | 929 | RecName: Full=Diacylglycerol kinase zeta; Short=DAG kinase zeta; AltName: Full=104 kDa diacylglycerol kinase; AltName: Full=DGK-IV; AltName: Full=Diglyceride kinase zeta; Short=DGK-zeta [Rattus norvegicus] |