Gene/Proteome Database (LMPD)

LMPD ID
LMP012775
Gene ID
81919
Species
Rattus norvegicus (Rat)
Gene Name
fucosyltransferase 1
Gene Symbol
Fut1
Synonyms
Futa;
Alternate Names
galactoside 2-alpha-L-fucosyltransferase 1; alpha(1,2)FT 1; alpha 12-fucosyltransferase; alpha12-fucosyltransferase a; alpha 1,2-fucosyltransferase A; GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1; fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase);
Chromosome
1
Map Location
1q22-q31
EC Number
2.4.1.69
Summary
catalyzes the formation of H antigen, a precursor of A and B antigens [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Fut1

Proteins

galactoside 2-alpha-L-fucosyltransferase 1
Refseq ID NP_112515
Protein GI 13676841
UniProt ID Q10980
mRNA ID NM_031236
Length 376
MWTPSRKQLCLAFLSVCVLSAGSFFFHLNGGNFFQNALTFSVLCPDYHLLKSPVAMVCLPYPSNASSGSPSCPEQSLLSGTWTITPGGRFGNQMGQYATLLALAQLNGRRAFIQPEMHTTLAPVFRISLPVLDPEVDSLTPWQHLVLHDWMSEEYSHLEDPFLKLSGFPCSWTFFHHLREQIRREFTLHDHLREDAQRLLSGLRIGPAGIRPRTYVGVHVRRGDYLEVMPNRWKGVVGDRAYLQKAMDWFRARHKDPIFVVTSNGMRWCLENIDTSHGDVVFAGNGQEGTPGKDFALLTQCNHTIMTIGTFGFWAAYLAGGDTVYLANFTLPDSEFLKIFRPKAAFLPEWVGINADLSPLQAQFDPWETDSLFRLA

Gene Information

Entrez Gene ID
81919
Gene Name
fucosyltransferase 1
Gene Symbol
Fut1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008107 IEA:UniProtKB-EC F galactoside 2-alpha-L-fucosyltransferase activity
GO:0006486 IEA:UniProtKB-UniPathway P protein glycosylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00603 Glycosphingolipid biosynthesis - globo series
rno00603 Glycosphingolipid biosynthesis - globo series
ko00601 Glycosphingolipid biosynthesis - lacto and neolacto series
rno00601 Glycosphingolipid biosynthesis - lacto and neolacto series
rno01100 Metabolic pathways

Domain Information

InterPro Annotations

Accession Description
IPR002516 Glycosyl transferase, family 11

UniProt Annotations

Entry Information

Gene Name
fucosyltransferase 1
Protein Entry
FUT1_RAT
UniProt ID
Q10980
Species
Rat

Comments

Comment Type Description
Catalytic Activity GDP-beta-L-fucose + beta-D-galactosyl-(1->3)- N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta- D-glucosyl-(1<->1)-ceramide = GDP + alpha-L-fucosyl-(1->2)-beta-D- galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D- galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide.
Miscellaneous There are two genes (Fut1 and Fut2) which encode galactoside 2-L-fucosyltransferase. They are expressed in a tissue-specific manner with expression restricted to cells of mesodermal or endodermal origin respectively.
Pathway Protein modification; protein glycosylation.
Similarity Belongs to the glycosyltransferase 11 family
Subcellular Location Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein . Note=Membrane-bound form in trans cisternae of Golgi

Identical and Related Proteins

Unique RefSeq proteins for LMP012775 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13676841 RefSeq NP_112515 376 galactoside 2-alpha-L-fucosyltransferase 1

Identical Sequences to LMP012775 proteins

Reference Database Accession Length Protein Name
GI:13676841 GenBank EDM07325.1 376 fucosyltransferase 1 [Rattus norvegicus]
GI:13676841 GenBank AFG79843.1 376 Sequence 102 from patent US 8137928
GI:13676841 RefSeq XP_008757642.1 376 PREDICTED: galactoside 2-alpha-L-fucosyltransferase 1 isoform X1 [Rattus norvegicus]
GI:13676841 SwissProt Q10980.2 376 RecName: Full=Galactoside 2-alpha-L-fucosyltransferase 1; AltName: Full=Alpha 1,2-fucosyltransferase A; AltName: Full=Alpha(1,2)FT 1; AltName: Full=Fucosyltransferase 1; AltName: Full=GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1 [Rattus norvegicus]

Related Sequences to LMP012775 proteins

Reference Database Accession Length Protein Name
GI:13676841 DBBJ BAA21741.1 376 alpha 1,2-fucosyltransferase [Rattus norvegicus]
GI:13676841 GenBank AFG79843.1 376 Sequence 102 from patent US 8137928
GI:13676841 RefSeq XP_008757642.1 376 PREDICTED: galactoside 2-alpha-L-fucosyltransferase 1 isoform X1 [Rattus norvegicus]