Gene/Proteome Database (LMPD)

LMPD ID
LMP012776
Gene ID
81924
Species
Rattus norvegicus (Rat)
Gene Name
cytochrome P450, family 8, subfamily b, polypeptide 1
Gene Symbol
Cyp8b1
Alternate Names
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase; cytochrome P450 8b1 sterol 12 alpha-hydrolase; cytochrome P450, 8b1, sterol 12 alpha-hydrolase;
Chromosome
8
Map Location
8q32
Summary
member of the cytochrome P450 enzyme superfamily; endoplasmic reticulum membrane protein; plays a role in sterol metabolism; human homolog is unique among cytochrome P450 genes in that it is intronless [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Cyp8b1

Proteins

7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase precursor
Refseq ID NP_112520
Protein GI 13676851
UniProt ID Q9WVT5
mRNA ID NM_031241
Length 499
MLWGSVLGALLMAVGCLCLSLLPRHRRPWEPPLDKGFVPWLGHTMAFRKNMFEFLKGMRAKHGDVFTLQLGGQYFTFVMDPLSFGPIIKSTQKVLDFVTYARELVFKVFGYQSMDEDHQMLHVASTKHLMGQGLEDLNRAMLDSLSLVMLGPKGRSLGARSWCEDGLFHFCYSILFKAGFLSLFGCTKDKEQDLDEADELFRKFRRFDLLFPRFVYSLLGPLEWVEVSQLQRLFHQRLSVEQNLEKDGISNWLGFMLRFLRERGMASSMQDKFNFMMLWASQGNTGPTCFWALLFLLKHQDAMKAVREEATRVLGEARLEAETSFAFTLSALKCTPVLDSVMEETLRLCATPTLLGVVQEDYVLKMASGQEYQIRRGDKVALFPYLSVHMDPDIHPEPTTFKYNRFLNPDGTRKVDFYKSGKKIHHYNMPWGSGVSICPGRFFAPSEMKTFVLLMVMYFDFELVDPDMPVPPIDPRRWGFGTSQPSHEVRFRYRLKPMQ
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1837 peptide sequence: MLWGSVLGALLMAVGCLC

Gene Information

Entrez Gene ID
81924
Gene Name
cytochrome P450, family 8, subfamily b, polypeptide 1
Gene Symbol
Cyp8b1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IBA:RefGenome C endoplasmic reticulum
GO:0005789 IEA:UniProtKB-SubCell C endoplasmic reticulum membrane
GO:0020037 IBA:RefGenome F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0008397 IDA:RGD F sterol 12-alpha-hydroxylase activity
GO:0006629 IBA:RefGenome P lipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
ko00120 Primary bile acid biosynthesis
rno00120 Primary bile acid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002403 Cytochrome P450, E-class, group IV
IPR024204 Cytochrome P450, cholesterol 7-alpha-monooxygenase-type

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 8, subfamily b, polypeptide 1
Protein Entry
Q9WVT5_RAT
UniProt ID
Q9WVT5
Species
Rat

Comments

Comment Type Description
Cofactor Note=Heme group. {ECO:0000256|PIRNR:PIRNR000047, ECO:0000256|PIRSR:PIRSR000047-1};
Similarity Belongs to the cytochrome P450 family
Subcellular Location Endoplasmic reticulum membrane .

Identical and Related Proteins

Unique RefSeq proteins for LMP012776 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13676851 RefSeq NP_112520 499 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase precursor

Identical Sequences to LMP012776 proteins

Reference Database Accession Length Protein Name
GI:13676851 DBBJ BAA82169.1 499 sterol 12alpha-hydroxylase P450 [Rattus norvegicus]

Related Sequences to LMP012776 proteins

Reference Database Accession Length Protein Name
GI:13676851 DBBJ BAA76602.1 499 sterol 12-alpha hydroxylase [Rattus norvegicus]
GI:13676851 DBBJ BAA82169.1 499 sterol 12alpha-hydroxylase P450 [Rattus norvegicus]
GI:13676851 GenBank EDL76812.1 499 cytochrome P450, family 8, subfamily b, polypeptide 1 [Rattus norvegicus]