Gene/Proteome Database (LMPD)

LMPD ID
LMP012779
Gene ID
83505
Species
Rattus norvegicus (Rat)
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Gene Symbol
St3gal5
Synonyms
Siat9;
Alternate Names
lactosylceramide alpha-2,3-sialyltransferase; ST3GalV; ST3Gal V; GM3 synthase; ganglioside GM3 synthase; CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase); sialyltransferase 9 (CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; GM3 synthase);
Chromosome
4
Map Location
4q33
EC Number
2.4.99.9
Summary
mouse homolog is an alpha 2,3-sialyltransferase that has activity toward lactosylceramide (LacCer) and synthesizes GM3 [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for St3gal5

Proteins

lactosylceramide alpha-2,3-sialyltransferase
Refseq ID NP_112627
Protein GI 78126151
UniProt ID Q68G12
mRNA ID NM_031337
Length 387
MPNEFTSAKLRSDCSRTSLQWYTQTQHKMRRPSLLLKDILKCMLVVFGVWLLYILKLNYTAEECDMKKLNYVDPARIKRAHRNTQEVFQKECRPGHAKKTMDLLFKGKYSMDLEPFVQKIPTASEAELKYDPPFGFRKFSSKVQSLLDMLPEHDFPEHLRAKHCKRCVVIGNGGILHGLELGHALNQFDVVIRLNSAPIEGYSEHVGNKTTIRMTYPEGAPLSDAEYYANDLFVAVLFKSVDFKWLQAMVKNESLPFWIRLFFWKQVAEKIPLQPKHFRILNPVIIKETAFDILQYSEPQSRFWGHDKNIPTIGIIAIVLATHLCDEVSLAGFGYDLSQPRTPLHYFDSQCMGAMNWQVMHNVTTETQFLQKLIKEGVVQDLSGGIH

Gene Information

Entrez Gene ID
83505
Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Gene Symbol
St3gal5
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030173 IEA:InterPro C integral component of Golgi membrane
GO:0047291 ISS:UniProtKB F lactosylceramide alpha-2,3-sialyltransferase activity
GO:0006486 IEA:InterPro P protein glycosylation
GO:0097503 ISS:GOC P sialylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00604 Glycosphingolipid biosynthesis - ganglio series
rno00604 Glycosphingolipid biosynthesis - ganglio series
M00069 Glycosphingolipid biosynthesis, ganglio series, LacCer => GT3
rno01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
5953739 Asparagine N-linked glycosylation
5953738 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
5953345 Metabolism of proteins
5953728 Post-translational protein modification
5954270 Sialic acid metabolism
5953737 Synthesis of substrates in N-glycan biosythesis

Domain Information

InterPro Annotations

Accession Description
IPR001675 Glycosyl transferase, family 29
IPR012163 Sialyltransferase

UniProt Annotations

Entry Information

Gene Name
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
Protein Entry
SIAT9_RAT
UniProt ID
Q68G12
Species
Rat

Comments

Comment Type Description
Catalytic Activity CMP-N-acetylneuraminate + beta-D-galactosyl- (1->4)-beta-D-glucosyl-(1<->1)-ceramide = CMP + alpha-N- acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (1<->1)-ceramide.
Function Catalyzes the formation of ganglioside GM3 (alpha-N- acetylneuraminyl-2,3-beta-D-galactosyl-1, 4-beta-D- glucosylceramide)
Sequence Caution Sequence=BAA33492.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the glycosyltransferase 29 family
Subcellular Location Golgi apparatus membrane ; Single-pass type II membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012779 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
78126151 RefSeq NP_112627 387 lactosylceramide alpha-2,3-sialyltransferase

Identical Sequences to LMP012779 proteins

Reference Database Accession Length Protein Name
GI:78126151 GenBank EDL91013.1 387 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [Rattus norvegicus]
GI:78126151 RefSeq XP_006236739.1 387 PREDICTED: lactosylceramide alpha-2,3-sialyltransferase isoform X1 [Rattus norvegicus]
GI:78126151 RefSeq XP_006236741.1 387 PREDICTED: lactosylceramide alpha-2,3-sialyltransferase isoform X1 [Rattus norvegicus]
GI:78126151 RefSeq XP_008761218.1 387 PREDICTED: lactosylceramide alpha-2,3-sialyltransferase isoform X1 [Rattus norvegicus]

Related Sequences to LMP012779 proteins

Reference Database Accession Length Protein Name
GI:78126151 GenBank EDL91013.1 387 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 [Rattus norvegicus]
GI:78126151 RefSeq XP_008761218.1 387 PREDICTED: lactosylceramide alpha-2,3-sialyltransferase isoform X1 [Rattus norvegicus]
GI:78126151 SwissProt Q68G12.1 387 RecName: Full=Lactosylceramide alpha-2,3-sialyltransferase; AltName: Full=CMP-NeuAc:lactosylceramide alpha-2,3-sialyltransferase; AltName: Full=Ganglioside GM3 synthase; AltName: Full=ST3Gal V; Short=ST3GalV; AltName: Full=Sialyltransferase 9 [Rattus norvegicus]