Gene/Proteome Database (LMPD)

LMPD ID
LMP012780
Gene ID
83510
Species
Rattus norvegicus (Rat)
Gene Name
lysophospholipase II
Gene Symbol
Lypla2
Alternate Names
acyl-protein thioesterase 2; APT-2; LPL-II; lysoPLA II; lysophospholipase 2;
Chromosome
5
Map Location
5q36
EC Number
3.1.2.-
Summary
mouse homolog displays preferential activity on zwitterionic lysophospholipid substrates; mouse and rat homolog share the Gly-X-Ser-X-Gly esterase/lipase consensus sequence [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Lypla2

Proteins

acyl-protein thioesterase 2
Refseq ID NP_112632
Protein GI 13786178
UniProt ID Q9QYL8
mRNA ID NM_031342
Length 231
MCGNNMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRNFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRTVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV

Gene Information

Entrez Gene ID
83510
Gene Name
lysophospholipase II
Gene Symbol
Lypla2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0006631 IEA:UniProtKB-KW P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR003140 Phospholipase/carboxylesterase/thioesterase

UniProt Annotations

Entry Information

Gene Name
lysophospholipase II
Protein Entry
LYPA2_RAT
UniProt ID
Q9QYL8
Species
Rat

Comments

Comment Type Description
Catalytic Activity Palmitoyl-protein + H(2)O = palmitate + protein.
Function May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Has lysophospholipase activity. Deacylates GAP43 (By similarity)
Similarity Belongs to the AB hydrolase superfamily. AB hydrolase 2 family
Subcellular Location Cytoplasm .

Identical and Related Proteins

Unique RefSeq proteins for LMP012780 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13786178 RefSeq NP_112632 231 acyl-protein thioesterase 2

Identical Sequences to LMP012780 proteins

Reference Database Accession Length Protein Name
GI:13786178 GenBank AAH70503.1 231 Lysophospholipase 2 [Rattus norvegicus]
GI:13786178 GenBank EDL80787.1 231 lysophospholipase 2, isoform CRA_a [Rattus norvegicus]
GI:13786178 GenBank EDL80788.1 231 lysophospholipase 2, isoform CRA_a [Rattus norvegicus]
GI:13786178 GenBank EDL80789.1 231 lysophospholipase 2, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012780 proteins

Reference Database Accession Length Protein Name
GI:13786178 GenBank EDL80787.1 231 lysophospholipase 2, isoform CRA_a [Rattus norvegicus]
GI:13786178 GenBank EDL80788.1 231 lysophospholipase 2, isoform CRA_a [Rattus norvegicus]
GI:13786178 GenBank EDL80789.1 231 lysophospholipase 2, isoform CRA_a [Rattus norvegicus]