Gene/Proteome Database (LMPD)

LMPD ID
LMP012781
Gene ID
83512
Species
Rattus norvegicus (Rat)
Gene Name
fatty acid desaturase 2
Gene Symbol
Fads2
Synonyms
Fadsd6;
Alternate Names
fatty acid desaturase 2; D6D; delta-6 desaturase; delta(6) desaturase; fatty acid desaturase 6; delta-6 fatty acid desaturase; delta(6) fatty acid desaturase;
Chromosome
1
Map Location
1q43
EC Number
1.14.19.-

Proteins

fatty acid desaturase 2
Refseq ID NP_112634
Protein GI 13786182
UniProt ID Q9Z122
mRNA ID NM_031344
Length 444
MGKGGNQGEGSTELQAPMPTFRWEEIQKHNLRTDRWLVIDRKVYNVTKWSQRHPGGHRVIGHYSGEDATDAFRAFHLDLDFVGKFLKPLLIGELAPEEPSLDRGKSSQITEDFRALKKTAEDMNLFKTNHLFFFLLLSHIIVMESIAWFILSYFGNGWIPTVITAFVLATSQAQAGWLQHDYGHLSVYKKSIWNHIVHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDIKSLHVFVLGEWQPLEYGKKKLKYLPYNHQHEYFFLIGPPLLIPMYFQYQIIMTMIRRRDWVDLAWAISYYARFFYTYIPFYGILGALVFLNFIRFLESHWFVWVTQMNHIVMEIDLDHYRDWFSSQLAATCNVEQSFFNDWFSGHLNFQIEHHLFPTMPRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIVSSLKKSGELWLDAYLHK

Gene Information

Entrez Gene ID
83512
Gene Name
fatty acid desaturase 2
Gene Symbol
Fads2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0020037 IEA:InterPro F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004768 TAS:RGD F stearoyl-CoA 9-desaturase activity
GO:0006636 IEA:UniProtKB-UniPathway P unsaturated fatty acid biosynthetic process
GO:0042761 TAS:RGD P very long-chain fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko01040 Biosynthesis of unsaturated fatty acids
rno01040 Biosynthesis of unsaturated fatty acids
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
ko00592 alpha-Linolenic acid metabolism
rno00592 alpha-Linolenic acid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5954541 Linoleic acid (LA) metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954542 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
5954543 alpha-linolenic acid (ALA) metabolism

Domain Information

InterPro Annotations

Accession Description
IPR001199 Cytochrome b5-like heme/steroid binding domain
IPR005804 Fatty acid desaturase, type 1
IPR012171 Fatty acid/sphingolipid desaturase

UniProt Annotations

Entry Information

Gene Name
fatty acid desaturase 2
Protein Entry
FADS2_RAT
UniProt ID
Q9Z122
Species
Rat

Comments

Comment Type Description
Domain The histidine box domains may contain the active site and/or be involved in metal ion binding.
Function Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. {ECO:0000269|PubMed:10049752, ECO:0000269|PubMed:14563830, ECO:0000269|PubMed:22216341}.
Induction Inhibited by a shortage of insulin and an increase of glucagon
Pathway Lipid metabolism; polyunsaturated fatty acid biosynthesis.
Similarity Belongs to the fatty acid desaturase family
Similarity Contains 1 cytochrome b5 heme-binding domain
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity Highest activity is found in the liver and adrenals followed by the testes and other organs, absent in adipose tissue

Identical and Related Proteins

Unique RefSeq proteins for LMP012781 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13786182 RefSeq NP_112634 444 fatty acid desaturase 2

Identical Sequences to LMP012781 proteins

Reference Database Accession Length Protein Name
GI:13786182 DBBJ BAA75496.1 444 delta-6 fatty acid desaturase [Rattus norvegicus]
GI:13786182 GenBank AAH81776.1 444 Fatty acid desaturase 2 [Rattus norvegicus]
GI:13786182 GenBank EDM12790.1 444 fatty acid desaturase 2 [Rattus norvegicus]
GI:13786182 SwissProt Q9Z122.1 444 RecName: Full=Fatty acid desaturase 2; AltName: Full=Delta(6) fatty acid desaturase; Short=D6D; Short=Delta(6) desaturase; Short=Delta-6 desaturase [Rattus norvegicus]

Related Sequences to LMP012781 proteins

Reference Database Accession Length Protein Name
GI:13786182 DBBJ BAA75496.1 444 delta-6 fatty acid desaturase [Rattus norvegicus]
GI:13786182 GenBank AAH81776.1 444 Fatty acid desaturase 2 [Rattus norvegicus]
GI:13786182 GenBank EDM12790.1 444 fatty acid desaturase 2 [Rattus norvegicus]