Gene/Proteome Database (LMPD)

LMPD ID
LMP012782
Gene ID
83516
Species
Rattus norvegicus (Rat)
Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Gene Symbol
Ppargc1a
Synonyms
Ppargc1;
Alternate Names
peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1alpha; PGC-1-alpha; PPARGC-1-alpha; PPAR-gamma coactivator 1-alpha; peroxisome proliferative activated receptor gamma coactivator 1; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha;
Chromosome
14
Map Location
14q11
Summary
nuclear receptor coactivator; may mediate glucose homeostasis, and lipid homeostasis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ppargc1a

Proteins

peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Refseq ID NP_112637
Protein GI 13786188
UniProt ID Q9QYK2
mRNA ID NM_031347
Length 796
MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKSSVLSRGHEERKTKRPSLRLFGDHDYCQSVNSKTDILINISQELQDSRQLDFKDASCDWQGHICSSTDSSQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDKVDKTSELRDGNFSNEQFSKLPVFINSGLAMDGLFDDSEDENDKLSYPWDGTQSYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEANEHERLKRDEYRREYEKRESERAKQRERQKQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR

Gene Information

Entrez Gene ID
83516
Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Gene Symbol
Ppargc1a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IDA:RGD C cytosol
GO:0005634 IDA:RGD C nucleus
GO:0003682 IDA:RGD F chromatin binding
GO:0031490 ISS:UniProtKB F chromatin DNA binding
GO:0003677 ISS:UniProtKB F DNA binding
GO:0030374 IEA:Ensembl F ligand-dependent nuclear receptor transcription coactivator activity
GO:0000166 IEA:InterPro F nucleotide binding
GO:0003723 IEA:UniProtKB-KW F RNA binding
GO:0043565 ISS:UniProtKB F sequence-specific DNA binding
GO:0003713 IDA:RGD F transcription coactivator activity
GO:0008209 IEP:RGD P androgen metabolic process
GO:0071398 IEP:RGD P cellular response to fatty acid
GO:0071456 IEP:RGD P cellular response to hypoxia
GO:0071250 IEP:RGD P cellular response to nitrite
GO:0034599 ISS:UniProtKB P cellular response to oxidative stress
GO:0097067 IEP:RGD P cellular response to thyroid hormone stimulus
GO:0071356 IEP:RGD P cellular response to tumor necrosis factor
GO:0032922 ISS:UniProtKB P circadian regulation of gene expression
GO:0051552 IEP:RGD P flavone metabolic process
GO:0006012 IEP:RGD P galactose metabolic process
GO:0007005 IMP:RGD P mitochondrion organization
GO:0045820 IMP:RGD P negative regulation of glycolytic process
GO:0043524 ISS:UniProtKB P negative regulation of neuron apoptotic process
GO:1901215 ISS:UniProtKB P negative regulation of neuron death
GO:2000272 IMP:RGD P negative regulation of receptor activity
GO:0014912 IMP:RGD P negative regulation of smooth muscle cell migration
GO:0070997 IEA:Ensembl P neuron death
GO:2001171 ISS:UniProtKB P positive regulation of ATP biosynthetic process
GO:0031325 IMP:RGD P positive regulation of cellular metabolic process
GO:1901857 IEA:Ensembl P positive regulation of cellular respiration
GO:2000507 ISS:UniProtKB P positive regulation of energy homeostasis
GO:0046321 IMP:RGD P positive regulation of fatty acid oxidation
GO:1901860 IEA:Ensembl P positive regulation of mitochondrial DNA metabolic process
GO:0010822 ISS:UniProtKB P positive regulation of mitochondrion organization
GO:1901863 IEA:Ensembl P positive regulation of muscle tissue development
GO:0051091 ISS:UniProtKB P positive regulation of sequence-specific DNA binding transcription factor activity
GO:0048661 IMP:RGD P positive regulation of smooth muscle cell proliferation
GO:0045893 IMP:RGD P positive regulation of transcription, DNA-templated
GO:0045944 ISS:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0042752 ISS:UniProtKB P regulation of circadian rhythm
GO:2000310 IMP:RGD P regulation of N-methyl-D-aspartate selective glutamate receptor activity
GO:0006355 ISS:UniProtKB P regulation of transcription, DNA-templated
GO:0022904 ISS:UniProtKB P respiratory electron transport chain
GO:0014823 IEP:RGD P response to activity
GO:0009409 IEP:RGD P response to cold
GO:0042493 IEP:RGD P response to drug
GO:0071871 IEP:RGD P response to epinephrine
GO:0001666 IEP:RGD P response to hypoxia
GO:0043201 IEP:RGD P response to leucine
GO:0014850 ISS:UniProtKB P response to muscle activity
GO:0071873 IEP:RGD P response to norepinephrine
GO:0031667 IEP:RGD P response to nutrient levels
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0042594 IEP:RGD P response to starvation
GO:0036273 IEP:RGD P response to statin
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
ko04920 Adipocytokine signaling pathway
rno04920 Adipocytokine signaling pathway
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko05016 Huntington's disease
rno05016 Huntington's disease
ko04910 Insulin signaling pathway
rno04910 Insulin signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
5954481 Activation of PPARGC1A (PGC-1alpha) by phosphorylation
5954332 BMAL1:CLOCK,NPAS2 activates circadian gene expression
5954223 Circadian Clock
5953533 Developmental Biology
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953600 Mitochondrial biogenesis
5953601 Organelle biogenesis and maintenance
5954333 PPARA activates gene expression
5954222 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
5954224 REV-ERBA represses gene expression
5954225 RORA activates circadian gene expression
5953599 Transcriptional activation of mitochondrial biogenesis
5954166 Transcriptional regulation of white adipocyte differentiation

Domain Information

InterPro Annotations

Accession Description
IPR012677 Nucleotide-binding alpha-beta plait domain
IPR000504 RNA recognition motif domain

UniProt Annotations

Entry Information

Gene Name
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
Protein Entry
PRGC1_RAT
UniProt ID
Q9QYK2
Species
Rat

Comments

Comment Type Description
Function Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity)
Induction Up-regulated in brown adipose tissue of diabetic fatty (fa/fa) rats. Exposure of fa/fa rats to cold resulted in a much smaller increase as compared to lean rats in which a 2.6 fold increase was seen. Leptin is required for normal basal and cold- stimulated expression in brown adipose tissue and hyperleptinemia rapidly up-regulates its expression. It is induced not only by cold exposure but also by prolonged low-intensity physical exercise in epitrochlearis muscle. {ECO:0000269|PubMed:10913342, ECO:0000269|PubMed:11108270}.
Ptm Heavily acetylated by GCN5 and biologically inactive under conditions of high nutrients. Deacetylated by SIRT1 in low nutrients/high NAD conditions (By similarity)
Ptm Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2
Ptm Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation
Similarity Contains 1 RRM (RNA recognition motif) domain
Subcellular Location Nucleus . Nucleus, PML body .
Subunit Homooligomer. Interacts with MYBBP1A; inhibits MYBBP1A transcriptional activation. Interacts with PRDM16, LPIN1 and PML. Interacts (via LXXLL motif) with RORA and RORC (via AF-2 motif); activates RORA and RORC transcriptional activation. Interacts with LRPPRC. Interacts with RNF34 (via RING-type zinc finger)

Identical and Related Proteins

Unique RefSeq proteins for LMP012782 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13786188 RefSeq NP_112637 796 peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Identical Sequences to LMP012782 proteins

Reference Database Accession Length Protein Name
GI:13786188 DBBJ BAA88982.1 796 PPAR gamma coactivator [Rattus norvegicus]
GI:13786188 GenBank AAO89279.1 796 PPAR gamma coactivator 1 [Rattus norvegicus]
GI:13786188 GenBank EDL99899.1 796 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, isoform CRA_b [Rattus norvegicus]
GI:13786188 SwissProt Q9QYK2.1 796 RecName: Full=Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Short=PGC-1-alpha; Short=PPAR-gamma coactivator 1-alpha; Short=PPARGC-1-alpha [Rattus norvegicus]

Related Sequences to LMP012782 proteins

Reference Database Accession Length Protein Name
GI:13786188 DBBJ BAA88982.1 796 PPAR gamma coactivator [Rattus norvegicus]
GI:13786188 GenBank AAO89279.1 796 PPAR gamma coactivator 1 [Rattus norvegicus]
GI:13786188 GenBank EDL99899.1 796 peroxisome proliferative activated receptor, gamma, coactivator 1 alpha, isoform CRA_b [Rattus norvegicus]