Gene/Proteome Database (LMPD)

LMPD ID
LMP012785
Gene ID
83537
Species
Rattus norvegicus (Rat)
Gene Name
sphingomyelin phosphodiesterase 2, neutral membrane
Gene Symbol
Smpd2
Synonyms
nSMase;
Alternate Names
sphingomyelin phosphodiesterase 2; N-SMase; lyso-PAF-PLC; neutral sphingomyelinase; lyso-platelet-activating factor-phospholipase C;
Chromosome
20
Map Location
20q12
EC Number
3.1.4.12
Summary
catalyzes the Mg2+ dependent hydrolysis of sphingomyelin to form N-acylsphingosine and choline phosphate; also has a lower activity for the hydrolysis of lyso-platelet activating factor to 1-alkylglycerol [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Smpd2

Proteins

sphingomyelin phosphodiesterase 2
Refseq ID NP_112650
Protein GI 14389301
UniProt ID Q9ET64
mRNA ID NM_031360
Length 422
MKHNFSLRLRVFNLNCWDIPYLSKHRADRMKRLGDFLNLESFDLALLEEVWSEQDFQYLKQKLSLTYPDAHYFRSGIIGSGLCVFSRHPIQEIVQHVYTLNGYPYKFYHGDWFCGKAVGLLVLHLSGLVLNAYVTHLHAEYSRQKDIYFAHRVAQAWELAQFIHHTSKKANVVLLCGDLNMHPKDLGCCLLKEWTGLRDAFVETEDFKGSEDGCTMVPKNCYVSQQDLGPFPFGVRIDYVLYKAVSGFHICCKTLKTTTGCDPHNGTPFSDHEALMATLCVKHSPPQEDPCSAHGSAERSALISALREARTELGRGIAQARWWAALFGYVMILGLSLLVLLCVLAAGEEAREVAIMLWTPSVGLVLGAGAVYLFHKQEAKSLCRAQAEIQHVLTRTTETQDLGSEPHPTHCRQQEADRAEEK

Gene Information

Entrez Gene ID
83537
Gene Name
sphingomyelin phosphodiesterase 2, neutral membrane
Gene Symbol
Smpd2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005901 IDA:RGD C caveola
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:RGD C membrane
GO:0005886 TAS:Reactome C plasma membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004767 IDA:RGD F sphingomyelin phosphodiesterase activity
GO:0046513 IDA:RGD P ceramide biosynthetic process
GO:0035556 IMP:RGD P intracellular signal transduction
GO:0009612 IMP:RGD P response to mechanical stimulus

KEGG Pathway Links

KEGG Pathway ID Description
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5953955 Ceramide signalling
5954485 Glycosphingolipid metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953945 p75 NTR receptor-mediated signalling
5953395 Signalling by NGF
5953381 Signal Transduction
5954267 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase

UniProt Annotations

Entry Information

Gene Name
sphingomyelin phosphodiesterase 2, neutral membrane
Protein Entry
NSMA_RAT
UniProt ID
Q9ET64
Species
Rat

Comments

Comment Type Description
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Function Converts sphingomyelin to ceramide. Hydrolyze 1-acyl-2- lyso-sn-glycero-3-phosphocholine (lyso-PC) and 1-O-alkyl-2-lyso- sn-glycero-3-phosphocholine (lyso-platelet-activating factor). The physiological substrate seems to be Lyso-PAF.
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the neutral sphingomyelinase family
Subcellular Location Membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP012785 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14389301 RefSeq NP_112650 422 sphingomyelin phosphodiesterase 2

Identical Sequences to LMP012785 proteins

Reference Database Accession Length Protein Name
GI:14389301 GenBank AAH91139.1 422 Sphingomyelin phosphodiesterase 2, neutral [Rattus norvegicus]
GI:14389301 GenBank EDL99735.1 422 sphingomyelin phosphodiesterase 2, neutral, isoform CRA_b [Rattus norvegicus]
GI:14389301 RefSeq XP_008771229.1 422 PREDICTED: sphingomyelin phosphodiesterase 2 isoform X1 [Rattus norvegicus]
GI:14389301 SwissProt Q9ET64.1 422 RecName: Full=Sphingomyelin phosphodiesterase 2; AltName: Full=Lyso-platelet-activating factor-phospholipase C; Short=Lyso-PAF-PLC; AltName: Full=Neutral sphingomyelinase; Short=N-SMase; Short=nSMase [Rattus norvegicus]

Related Sequences to LMP012785 proteins

Reference Database Accession Length Protein Name
GI:14389301 GenBank EDL99735.1 422 sphingomyelin phosphodiesterase 2, neutral, isoform CRA_b [Rattus norvegicus]
GI:14389301 RefSeq XP_008771229.1 422 PREDICTED: sphingomyelin phosphodiesterase 2 isoform X1 [Rattus norvegicus]
GI:14389301 SwissProt Q9ET64.1 422 RecName: Full=Sphingomyelin phosphodiesterase 2; AltName: Full=Lyso-platelet-activating factor-phospholipase C; Short=Lyso-PAF-PLC; AltName: Full=Neutral sphingomyelinase; Short=N-SMase; Short=nSMase [Rattus norvegicus]