Gene/Proteome Database (LMPD)

LMPD ID
LMP012786
Gene ID
83569
Species
Rattus norvegicus (Rat)
Gene Name
ATP-binding cassette, subfamily B (MDR/TAP), member 11
Gene Symbol
Abcb11
Synonyms
Bsep; Spgp;
Alternate Names
bile salt export pump; sister of P-glycoprotein; ATP-binding cassette sub-family B member 11; ATP-binding cassette, sub-family B (MDR/TAP), member 11;
Chromosome
3
Map Location
chromosome:3
Summary
acts as an ATP-dependent bile salt export pump; transports taurochenodeoxycholate, taurocholate, and other bile salts [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Abcb11

Proteins

bile salt export pump
Refseq ID NP_113948
Protein GI 13929072
UniProt ID O70127
mRNA ID NM_031760
Length 1321
MSDSVILRSVKKFGEENHAFESDGSHNNDKKSRLQDKMKEGDIRVGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGIMTDIFIKYDIERQELEIPGKACVNNTIVWINSSFHQNMTNGTVCGLVDIESEMIKFSGIYAGVGMTVLILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDCTSVGELNSRFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAKFTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMWCLIFFCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGREDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGVYFMLVTLQSQGDNAHKETSIMGKDATEGGTLERTFSRGSYRDSLRASIRQRSKSQLSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVEPAPVRRILKYNIPEWHYILVGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSHVFRVVSSVALSATAVGRTFSYTPSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLVITGAPIS

Gene Information

Entrez Gene ID
83569
Gene Name
ATP-binding cassette, subfamily B (MDR/TAP), member 11
Gene Symbol
Abcb11
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:RGD C Golgi apparatus
GO:0000139 IDA:RGD C Golgi membrane
GO:0016324 IDA:RGD C apical plasma membrane
GO:0016021 IBA:RefGenome C integral component of membrane
GO:0005886 IDA:RGD C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0042626 IBA:RefGenome F ATPase activity, coupled to transmembrane movement of substances
GO:0015126 IDA:RGD F canalicular bile acid transmembrane transporter activity
GO:0015238 IDA:RGD F drug transmembrane transporter activity
GO:0015722 IDA:RGD P canalicular bile acid transport
GO:0046618 IDA:RGD P drug export
GO:0006855 IDA:GOC P drug transmembrane transport
GO:0042493 IMP:RGD P response to drug
GO:0043627 IEP:RGD P response to estrogen
GO:0006979 IEP:RGD P response to oxidative stress

KEGG Pathway Links

KEGG Pathway ID Description
ko02010 ABC transporters
rno02010 ABC transporters
ko04976 Bile secretion
rno04976 Bile secretion

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR011527 ABC transporter type 1, transmembrane domain
IPR017871 ABC transporter, conserved site
IPR003439 ABC_transporter-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
ATP-binding cassette, subfamily B (MDR/TAP), member 11
Protein Entry
ABCBB_RAT
UniProt ID
O70127
Species
Rat

Comments

Comment Type Description
Domain Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
Function Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes.
Interaction Q7TSE9:Hax1; NbExp=5; IntAct=EBI-930036, EBI-930005;
Similarity Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily
Similarity Contains 2 ABC transmembrane type-1 domains
Similarity Contains 2 ABC transporter domains
Subcellular Location Membrane; Multi-pass membrane protein.
Subunit Interacts with HAX1
Tissue Specificity Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ.

Identical and Related Proteins

Unique RefSeq proteins for LMP012786 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13929072 RefSeq NP_113948 1321 bile salt export pump

Identical Sequences to LMP012786 proteins

Reference Database Accession Length Protein Name
GI:13929072 GenBank AAC40084.1 1321 bile salt export pump [Rattus norvegicus]
GI:13929072 SwissProt O70127.1 1321 RecName: Full=Bile salt export pump; AltName: Full=ATP-binding cassette sub-family B member 11; AltName: Full=Sister of P-glycoprotein [Rattus norvegicus]

Related Sequences to LMP012786 proteins

Reference Database Accession Length Protein Name
GI:13929072 GenBank AAC40084.1 1321 bile salt export pump [Rattus norvegicus]
GI:13929072 GenBank AAC24753.1 1321 P-glycoprotein sister [Rattus norvegicus]
GI:13929072 SwissProt O70127.1 1321 RecName: Full=Bile salt export pump; AltName: Full=ATP-binding cassette sub-family B member 11; AltName: Full=Sister of P-glycoprotein [Rattus norvegicus]