Gene/Proteome Database (LMPD)

LMPD ID
LMP012788
Gene ID
83574
Species
Rattus norvegicus (Rat)
Gene Name
retinoid X receptor gamma
Gene Symbol
Rxrg
Alternate Names
retinoic acid receptor RXR-gamma; RXR gamma-1; retinoic X receptor gamma-1; nuclear receptor subfamily 2 group B member 3;
Chromosome
13
Map Location
13q24
Summary
receptor for retinoid 9-cis-retinoic acid; may be involved in differentiation of limb myoblasts [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Rxrg

Proteins

retinoic acid receptor RXR-gamma
Refseq ID NP_113953
Protein GI 61657903
UniProt ID Q5BJR8
mRNA ID NM_031765
Length 463
MYGNYSHFMKFPTGFGGSPGHTGSTSMSPSVALPTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVVPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECASTGHEDMPVERILEAELAVEPKTESYGDMSVESSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMRMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT

Gene Information

Entrez Gene ID
83574
Gene Name
retinoid X receptor gamma
Gene Symbol
Rxrg
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:RGD C nucleus
GO:0004886 IEA:Ensembl F 9-cis retinoic acid receptor activity
GO:0043565 IEA:Ensembl F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0032870 IEP:RGD P cellular response to hormone stimulus
GO:0007507 IEP:RGD P heart development
GO:0030182 IEP:RGD P neuron differentiation
GO:0007422 IEP:RGD P peripheral nervous system development
GO:0045944 IEA:Ensembl P positive regulation of transcription from RNA polymerase II promoter
GO:0031641 IDA:RGD P regulation of myelination
GO:0014070 IEP:RGD P response to organic cyclic compound
GO:0032526 IEP:RGD P response to retinoic acid
GO:0007519 IEP:RGD P skeletal muscle tissue development

KEGG Pathway Links

KEGG Pathway ID Description
ko04920 Adipocytokine signaling pathway
rno04920 Adipocytokine signaling pathway
ko05223 Non-small cell lung cancer
rno05223 Non-small cell lung cancer
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway
rno05200 Pathways in cancer
ko05222 Small cell lung cancer
rno05222 Small cell lung cancer
ko05216 Thyroid cancer
rno05216 Thyroid cancer
rno04919 Thyroid hormone signaling pathway
ko05202 Transcriptional misregulation in cancer
rno05202 Transcriptional misregulation in cancer

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR021780 Nuclear/hormone receptor activator site AF-1
IPR000003 Retinoid X receptor/HNF4
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoid X receptor gamma
Protein Entry
RXRG_RAT
UniProt ID
Q5BJR8
Species
Rat

Comments

Comment Type Description
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity)
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
Subunit Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer
Tissue Specificity Resticted expression in adrenal gland, kidney, liver, brain and lungs. Strong expression in heart and lungs

Identical and Related Proteins

Unique RefSeq proteins for LMP012788 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
61657903 RefSeq NP_113953 463 retinoic acid receptor RXR-gamma

Identical Sequences to LMP012788 proteins

Reference Database Accession Length Protein Name
GI:61657903 GenBank AAH91363.1 463 Retinoid X receptor gamma [Rattus norvegicus]
GI:61657903 GenBank EDM09279.1 463 retinoid X receptor gamma, isoform CRA_a [Rattus norvegicus]
GI:61657903 SwissProt Q5BJR8.1 463 RecName: Full=Retinoic acid receptor RXR-gamma; AltName: Full=Nuclear receptor subfamily 2 group B member 3; AltName: Full=Retinoid X receptor gamma [Rattus norvegicus]

Related Sequences to LMP012788 proteins

Reference Database Accession Length Protein Name
GI:61657903 GenBank AAH91363.1 463 Retinoid X receptor gamma [Rattus norvegicus]
GI:61657903 GenBank EDM09279.1 463 retinoid X receptor gamma, isoform CRA_a [Rattus norvegicus]
GI:61657903 SwissProt Q5BJR8.1 463 RecName: Full=Retinoic acid receptor RXR-gamma; AltName: Full=Nuclear receptor subfamily 2 group B member 3; AltName: Full=Retinoid X receptor gamma [Rattus norvegicus]