Gene/Proteome Database (LMPD)

LMPD ID
LMP012790
Gene ID
83626
Species
Rattus norvegicus (Rat)
Gene Name
UDP-glucose ceramide glucosyltransferase
Gene Symbol
Ugcg
Alternate Names
ceramide glucosyltransferase; GCS; GLCT-1; glucosylceramide synthase; UDP-glucose:ceramide glycosyltransferase; UDP-glucose:N-acylsphingosine D-glucosyltransferase;
Chromosome
5
Map Location
5q24
EC Number
2.4.1.80
Summary
catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to ceramide to form glucosylceramide [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ugcg

Proteins

ceramide glucosyltransferase
Refseq ID NP_113983
Protein GI 25742623
UniProt ID Q9R0E0
mRNA ID NM_031795
Length 394
MALLDLAQEGMALFGFVLFVVLWLMHFMSIIYTRLHLNKKATDKQPYSKLPGVSLLKPLKGVDPNLINNLETFFELDYPKYEVLLCVQDHDDPAIEVCKKLLGKYPNVDARLFIGGKKVGINPKINNLMPAYEVAKYDLIWICDSGIRVIPDTLTDMVNQMTERVGLVHGLPYVADRQGFAATLEQVYFGTSHPRSYISANVTGFKCVTGMSCLMRKDVLDQAGGLIAFAQYIAEDYFMAKAIADRGWKFSMSTQVAMQNSGSYSISQFQSRMIRWTKLRINMLPATIICEPISECFVASLIIGWAAHHVFRWDIMVFFMCHCLAWFIFDYIQLRGVQGGTLCFSKLDYAVAWFIRESMTIYIFLSALWDPTISWRAGRYRLRCGGTAEEILDV

Gene Information

Entrez Gene ID
83626
Gene Name
UDP-glucose ceramide glucosyltransferase
Gene Symbol
Ugcg
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0008120 IDA:RGD F ceramide glucosyltransferase activity
GO:0006665 IEA:UniProtKB-UniPathway P sphingolipid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00066 Lactosylceramide biosynthesis
rno01100 Metabolic pathways
ko00600 Sphingolipid metabolism
rno00600 Sphingolipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5954485 Glycosphingolipid metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954267 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR025993 Ceramide glucosyltransferase
IPR029044 Nucleotide-diphospho-sugar transferases

UniProt Annotations

Entry Information

Gene Name
UDP-glucose ceramide glucosyltransferase
Protein Entry
CEGT_RAT
UniProt ID
Q9R0E0
Species
Rat

Comments

Comment Type Description
Catalytic Activity UDP-glucose + N-acylsphingosine = UDP + D- glucosyl-N-acylsphingosine
Function Catalyzes the first glycosylation step in glycosphingolipid biosynthesis, the transfer of glucose to ceramide. Able to use UDP-galactose to synthesize galactosylceramide with 10% of efficiency with which it utilizes UDP-glucose. May also serve as a "flippase"
Pathway Lipid metabolism; sphingolipid metabolism.
Similarity Belongs to the glycosyltransferase 2 family
Subcellular Location Golgi apparatus membrane ; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012790 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25742623 RefSeq NP_113983 394 ceramide glucosyltransferase

Identical Sequences to LMP012790 proteins

Reference Database Accession Length Protein Name
GI:25742623 GenBank AAD02464.1 394 UDP-glucose:ceramide glycosyltransferase [Rattus norvegicus]
GI:25742623 GenBank EDL91642.1 394 rCG32003, isoform CRA_a [Rattus norvegicus]
GI:25742623 GenBank EDL91643.1 394 rCG32003, isoform CRA_a [Rattus norvegicus]
GI:25742623 SwissProt Q9R0E0.1 394 RecName: Full=Ceramide glucosyltransferase; AltName: Full=GLCT-1; AltName: Full=Glucosylceramide synthase; Short=GCS; AltName: Full=UDP-glucose ceramide glucosyltransferase; AltName: Full=UDP-glucose:N-acylsphingosine D-glucosyltransferase [Rattus norvegicus]

Related Sequences to LMP012790 proteins

Reference Database Accession Length Protein Name
GI:25742623 GenBank AAD02464.1 394 UDP-glucose:ceramide glycosyltransferase [Rattus norvegicus]
GI:25742623 GenBank EDL91642.1 394 rCG32003, isoform CRA_a [Rattus norvegicus]
GI:25742623 SwissProt Q9R0E0.1 394 RecName: Full=Ceramide glucosyltransferase; AltName: Full=GLCT-1; AltName: Full=Glucosylceramide synthase; Short=GCS; AltName: Full=UDP-glucose ceramide glucosyltransferase; AltName: Full=UDP-glucose:N-acylsphingosine D-glucosyltransferase [Rattus norvegicus]