Gene/Proteome Database (LMPD)

LMPD ID
LMP012795
Gene ID
83724
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor coactivator 2
Gene Symbol
Ncoa2
Synonyms
Tif2;
Alternate Names
nuclear receptor coactivator 2; NCoA-2; transcriptional intermediary factor 2;
Chromosome
5
Map Location
5q11
Summary
binds to nuclear receptor complex leading to coactivation [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ncoa2

Proteins

nuclear receptor coactivator 2
Refseq ID NP_114010
Protein GI 13929174
UniProt ID Q9WUI9
mRNA ID NM_031822
Length 1465
MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMVNGGSWTGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDKQSCLICVARRVPMKERPALPSSESFTTRQDLQGKITFLDTSTMRDAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISIHMLHREQNVCVMNPDLTGQAMGKPLSPMSSSSPARQAMCSGNPGQDVALGSNMNFPMNGPREQMSMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGLNPGQPSSVLSPRHRMSPGVAGSPRVPPSQFSPAGSLHSPAGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGPSLASPDLKMGNSQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAQASCHPEEQKRPNDSSMPQAASEDRAEGHSRLHESKGQTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELNQESSGTAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQAIINDLMQLTADSSPVTPVGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRSSMPSGEWAPQSPAVRVTCAATTGAMNRPIQGGMIRNPTASIPMRANSQPGQRQMLQPQVMNIGPSELEMNMGGPQYNQQQAPPNQTAPWPESILPIDQASFGSQNRHPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQESSMMLEQKPPVFPQQYASQTQMAQGSYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQQNRQPLMNQISGVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPTGLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQPASDINGWAQGSMGGNSMFSQQSPPHFGQQANTSMYNNNMNINVSMATNTAGLSNMNQMTGQMSMTSVTSVPTSGLSSMGPEQVNDPALRGSSLFTTNQLPGMDMIKQEGDGSRKYC

Gene Information

Entrez Gene ID
83724
Gene Name
nuclear receptor coactivator 2
Gene Symbol
Ncoa2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030425 IDA:RGD C dendrite
GO:0043197 IDA:RGD C dendritic spine
GO:0005794 IDA:RGD C Golgi apparatus
GO:0005874 IDA:RGD C microtubule
GO:0043025 IDA:RGD C neuronal cell body
GO:0005634 IDA:RGD C nucleus
GO:0014069 IDA:RGD C postsynaptic density
GO:0048786 IDA:RGD C presynaptic active zone
GO:0005791 IDA:RGD C rough endoplasmic reticulum
GO:0070182 IPI:RGD F DNA polymerase binding
GO:0030331 IPI:RGD F estrogen receptor binding
GO:0035259 IPI:RGD F glucocorticoid receptor binding
GO:0004402 IEA:InterPro F histone acetyltransferase activity
GO:0016922 IPI:RGD F ligand-dependent nuclear receptor binding
GO:0030374 IEA:InterPro F ligand-dependent nuclear receptor transcription coactivator activity
GO:0030165 IPI:RGD F PDZ domain binding
GO:0033142 IPI:RGD F progesterone receptor binding
GO:0032403 IPI:RGD F protein complex binding
GO:0042974 IPI:RGD F retinoic acid receptor binding
GO:0046965 IPI:RGD F retinoid X receptor binding
GO:0004871 IEA:InterPro F signal transducer activity
GO:0046966 IPI:RGD F thyroid hormone receptor binding
GO:0003713 ISS:UniProtKB F transcription coactivator activity
GO:0021549 IEP:RGD P cerebellum development
GO:0008584 IEP:RGD P male gonad development
GO:0045925 IMP:RGD P positive regulation of female receptivity
GO:2000324 IMP:RGD P positive regulation of glucocorticoid receptor signaling pathway
GO:0045944 IMP:RGD P positive regulation of transcription from RNA polymerase II promoter
GO:0006351 IEA:UniProtKB-KW P transcription, DNA-templated

KEGG Pathway Links

KEGG Pathway ID Description
rno04919 Thyroid hormone signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR010011 Domain of unknown function DUF1518
IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
IPR017426 Nuclear receptor coactivator
IPR028822 Nuclear receptor coactivator 2
IPR009110 Nuclear receptor coactivator, interlocking
IPR014920 Nuclear receptor coactivator, Ncoa-type, interlocking
IPR008955 Nuclear receptor coactivator Src-1
IPR001610 PAC motif
IPR000014 PAS domain
IPR013767 PAS_fold
IPR014935 Steroid receptor coactivator

UniProt Annotations

Entry Information

Gene Name
nuclear receptor coactivator 2
Protein Entry
NCOA2_RAT
UniProt ID
Q9WUI9
Species
Rat

Comments

Comment Type Description
Domain Contains 2 C-terminal transcription activation domains (AD1 and AD2) that can function independently
Domain Contains four Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs. The LXXLL motifs are essential for the association with nuclear receptors and are, at least in part, functionally redundant (By similarity)
Domain The LLXXLXXXL motif is involved in transcriptional coactivation and CREBBP/CBP binding
Function Transcriptional coactivator for steroid receptors and nuclear receptors. Coactivator of the steroid binding domain (AF- 2) but not of the modulating N-terminal domain (AF-1). Required with NCOA1 to control energy balance between white and brown adipose tissues. Critical regulator of glucose metabolism regulation, acts as RORA coactivator to specifically modulate G6PC expression. Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (By similarity)
Similarity Belongs to the SRC/p160 nuclear receptor coactivator family
Similarity Contains 1 bHLH (basic helix-loop-helix) domain
Similarity Contains 1 PAS (PER-ARNT-SIM) domain
Subcellular Location Nucleus.
Subunit Present in a complex containing NCOA3, IKKA, IKKB, IKBKG and CREBBP. Interacts (via C-terminus) with CREBBP. Interacts with ESR1, HIF1A, NCOA1, APEX, NR3C1, NR3C2, CARM1, RARA, and RXRA. Present in a complex containing CARM1 and EP300/P300. Interacts with CASP8AP2 and TTLL5/STAMP. Interacts with PSMB9 and DDX5. Interacts (via LXXLL 1, 2 and 3 motifs) with RORA and RORC (via AF-2 motif). Interacts with RWDD3 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012795 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13929174 RefSeq NP_114010 1465 nuclear receptor coactivator 2

Identical Sequences to LMP012795 proteins

Reference Database Accession Length Protein Name
GI:13929174 GenBank AAD24587.1 1465 transcriptional intermediary factor 2 [Rattus norvegicus]
GI:13929174 SwissProt Q9WUI9.1 1465 RecName: Full=Nuclear receptor coactivator 2; Short=NCoA-2; AltName: Full=Transcriptional intermediary factor 2 [Rattus norvegicus]

Related Sequences to LMP012795 proteins

Reference Database Accession Length Protein Name
GI:13929174 GenBank AAD24587.1 1465 transcriptional intermediary factor 2 [Rattus norvegicus]
GI:13929174 RefSeq XP_006237807.1 1465 PREDICTED: nuclear receptor coactivator 2 isoform X1 [Rattus norvegicus]
GI:13929174 SwissProt Q9WUI9.1 1465 RecName: Full=Nuclear receptor coactivator 2; Short=NCoA-2; AltName: Full=Transcriptional intermediary factor 2 [Rattus norvegicus]