Gene/Proteome Database (LMPD)

LMPD ID
LMP012796
Gene ID
83791
Species
Rattus norvegicus (Rat)
Gene Name
farnesyl diphosphate synthase
Gene Symbol
Fdps
Synonyms
FPS; Ac2-125;
Alternate Names
farnesyl pyrophosphate synthase; CR 39; FPP synthase; FPP synthetase; geranyltranstransferase; dimethylallyltranstransferase; farnesyl diphosphate synthetase; farnesyl pyrophosphate synthetase; cholesterol-regulated 39 kDa protein; (2E,6E)-farnesyl diphosphate synthase; testis-specific farnesyl pyrophosphate synthetase; farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase);
Chromosome
2
Map Location
2q34
EC Number
2.5.1.10
Summary
catalyzes the conversion of geranyl diphosphate and isopentenyl diphosphate to diphosphate and trans, trans-farnesyl diphosphate in the isoprene biosynthetic pathway [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Fdps

Proteins

farnesyl pyrophosphate synthase
Refseq ID NP_114028
Protein GI 13929206
UniProt ID P05369
mRNA ID NM_031840
Length 353
MNGDQKLDVHNQEKQNFIQHFSQIVKVLTEDELGHPEKGDAITRIKEVLEYNTVGGKYNRGLTVVQTFQELVEPRKQDAESLQRALTVGWCVELLQAFFLVLDDIMDSSHTRRGQICWYQKPGIGLDAINDALLLEAAIYRLLKFYCREQPYYLNLLELFLQSSYQTEIGQTLDLITAPQGQVDLGRYTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANALKILLEMGEFFQIQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLLRATPQQRQILEENYGQKDPEKVARVKALYEELDLRSVFFKYEEDSYNRLKSLIEQCSAPLPPSIFLELANKIYKRRK

Gene Information

Entrez Gene ID
83791
Gene Name
farnesyl diphosphate synthase
Gene Symbol
Fdps
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005759 IDA:RGD C mitochondrial matrix
GO:0005777 IDA:UniProtKB C peroxisome
GO:0004161 IEA:UniProtKB-EC F dimethylallyltranstransferase activity
GO:0004311 IGI:RGD F farnesyltranstransferase activity
GO:0004337 IDA:RGD F geranyltranstransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0071398 IEP:RGD P cellular response to fatty acid
GO:0006695 TAS:RGD P cholesterol biosynthetic process
GO:0045337 IDA:RGD P farnesyl diphosphate biosynthetic process
GO:0033384 IEA:UniProtKB-UniPathway P geranyl diphosphate biosynthetic process
GO:0008299 IDA:RGD P isoprenoid biosynthetic process
GO:0008584 IEP:RGD P male gonad development
GO:0061051 IMP:RGD P positive regulation of cell growth involved in cardiac muscle cell development
GO:0045542 IMP:RGD P positive regulation of cholesterol biosynthetic process
GO:0070723 IEP:RGD P response to cholesterol
GO:0042493 IEP:RGD P response to drug
GO:0043434 IEP:RGD P response to peptide hormone
GO:0033574 IEP:RGD P response to testosterone
GO:0007283 IEP:RGD P spermatogenesis

KEGG Pathway Links

KEGG Pathway ID Description
ko05166 HTLV-I infection
rno05166 HTLV-I infection
ko05164 Influenza A
rno05164 Influenza A
rno01100 Metabolic pathways
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR008949 Isoprenoid synthase domain
IPR000092 Polyprenyl synthetase

UniProt Annotations

Entry Information

Gene Name
farnesyl diphosphate synthase
Protein Entry
FPPS_RAT
UniProt ID
P05369
Species
Rat

Comments

Comment Type Description
Catalytic Activity Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Catalytic Activity Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 3 Mg(2+) ions per subunit. ;
Enzyme Regulation Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell (By similarity)
Function Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity)
Pathway Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Pathway Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Similarity Belongs to the FPP/GGPP synthase family
Subcellular Location Cytoplasm.
Subunit Homodimer. Interacts with RSAD2 (By similarity)
Tissue Specificity Testis, liver, kidney, brain and adrenal gland.

Identical and Related Proteins

Unique RefSeq proteins for LMP012796 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13929206 RefSeq NP_114028 353 farnesyl pyrophosphate synthase

Identical Sequences to LMP012796 proteins

Reference Database Accession Length Protein Name
GI:13929206 GenBank AAA41143.1 353 farnesyl pyrophosphate synthetase [Rattus norvegicus]
GI:13929206 GenBank AAH59125.1 353 Farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) [Rattus norvegicus]
GI:13929206 GenBank EDM00669.1 353 rCG62519, isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012796 proteins

Reference Database Accession Length Protein Name
GI:13929206 GenBank AAA41143.1 353 farnesyl pyrophosphate synthetase [Rattus norvegicus]
GI:13929206 GenBank AAH59125.1 353 Farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) [Rattus norvegicus]
GI:13929206 GenBank EDM00669.1 353 rCG62519, isoform CRA_a [Rattus norvegicus]