Gene/Proteome Database (LMPD)

LMPD ID
LMP012797
Gene ID
83792
Species
Rattus norvegicus (Rat)
Gene Name
stearoyl-CoA desaturase (delta-9-desaturase)
Gene Symbol
Scd
Synonyms
Scd2;
Alternate Names
acyl-CoA desaturase 2; delta-9 desaturase 2; delta(9)-desaturase 2; fatty acid desaturase 2; stearoyl-CoA desaturase 2; stearoyl-Coenzyme A desaturase 2;
Chromosome
1
Map Location
1q54
EC Number
1.14.19.1
Summary
enzyme involved in the regulation of oleic acid synthesis in the peripheral nervous system [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Scd

Proteins

acyl-CoA desaturase 2
Refseq ID NP_114029
Protein GI 13929208
UniProt ID Q6P7B9
mRNA ID NM_031841
Length 358
MPAHILQEISGSYSATTTITAPPSGGQQNGGEKFEKNPHHWGADVRPEIKDDLYDPSYQDEEGPPPKLEYVWRNIILMALLHIGALYGITLVPSCKVYTCLFAYLYYVISALGITAGAHRLWSHRTYKARLPLRLFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFVNSLCVSTFLRYAVVLNATWLVNSAAHLYGYRPYDKNISSRENILVSMGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMALLGLAYDRKRVSKAAVLARIKRTGEESCKSG

Gene Information

Entrez Gene ID
83792
Gene Name
stearoyl-CoA desaturase (delta-9-desaturase)
Gene Symbol
Scd
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005506 IEA:InterPro F iron ion binding
GO:0004768 IDA:RGD F stearoyl-CoA 9-desaturase activity
GO:0006633 TAS:RGD P fatty acid biosynthetic process
GO:0042552 IEP:RGD P myelination

KEGG Pathway Links

KEGG Pathway ID Description
ko04152 AMPK signaling pathway
rno04152 AMPK signaling pathway
ko01040 Biosynthesis of unsaturated fatty acids
rno01040 Biosynthesis of unsaturated fatty acids
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
ko03320 PPAR signaling pathway
rno03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR005804 Fatty acid desaturase, type 1
IPR015876 Fatty acid desaturase, type 1, core
IPR001522 Fatty acid desaturase, type 1, C-terminal

UniProt Annotations

Entry Information

Gene Name
stearoyl-CoA desaturase (delta-9-desaturase)
Protein Entry
ACOD2_RAT
UniProt ID
Q6P7B9
Species
Rat

Comments

Comment Type Description
Catalytic Activity Stearoyl-CoA + 2 ferrocytochrome b5 + O(2) + 2 H(+) = oleoyl-CoA + 2 ferricytochrome b5 + 2 H(2)O.
Cofactor Name=Fe cation; Xref=ChEBI:CHEBI:24875;
Domain The histidine box domains may contain the active site and/or be involved in metal ion binding.
Function Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA
Similarity Belongs to the fatty acid desaturase family
Subcellular Location Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein .

Identical and Related Proteins

Unique RefSeq proteins for LMP012797 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
13929208 RefSeq NP_114029 358 acyl-CoA desaturase 2

Identical Sequences to LMP012797 proteins

Reference Database Accession Length Protein Name
GI:13929208 DBBJ BAA92436.1 358 stearoyl-CoA desaturase 2 [Rattus norvegicus]
GI:13929208 GenBank EDL94279.1 358 rCG57510, isoform CRA_b [Rattus norvegicus]

Related Sequences to LMP012797 proteins

Reference Database Accession Length Protein Name
GI:13929208 DBBJ BAA92436.1 358 stearoyl-CoA desaturase 2 [Rattus norvegicus]
GI:13929208 GenBank AAH61737.1 358 Stearoyl-CoA desaturase (delta-9-desaturase) [Rattus norvegicus]
GI:13929208 GenBank EDL94279.1 358 rCG57510, isoform CRA_b [Rattus norvegicus]