Gene/Proteome Database (LMPD)

LMPD ID
LMP012800
Gene ID
83826
Species
Rattus norvegicus (Rat)
Gene Name
nuclear receptor subfamily 5, group A, member 1
Gene Symbol
Nr5a1
Synonyms
Sf-1; Ad4bp; Ftzf1; Ad4BP/SF-1;
Alternate Names
steroidogenic factor 1; STF-1; adrenal 4-binding protein; fushi tarazu factor homolog 1; steroid hormone receptor Ad4BP;
Chromosome
3
Map Location
3q11
Summary
transcription factor; essential for adrenal and gonadal development [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Nr5a1

Proteins

steroidogenic factor 1
Refseq ID NP_001178028
Protein GI 300797824
UniProt ID P50569
mRNA ID NM_001191099
Length 462
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRPDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT

Gene Information

Entrez Gene ID
83826
Gene Name
nuclear receptor subfamily 5, group A, member 1
Gene Symbol
Nr5a1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:RGD C nucleus
GO:0003705 IEA:Ensembl F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003682 IEA:Ensembl F chromatin binding
GO:0003690 IDA:RGD F double-stranded DNA binding
GO:0004879 NAS:RGD F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005543 IEA:Ensembl F phospholipid binding
GO:0043565 IDA:RGD F sequence-specific DNA binding
GO:0003700 IMP:RGD F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0030325 IEA:Ensembl P adrenal gland development
GO:0030154 IEA:Ensembl P cell differentiation
GO:0008585 IEP:RGD P female gonad development
GO:0042445 IEA:Ensembl P hormone metabolic process
GO:0030522 NAS:GOC P intracellular receptor signaling pathway
GO:0001553 IEA:Ensembl P luteinization
GO:0051457 IEA:Ensembl P maintenance of protein location in nucleus
GO:0008584 IEA:Ensembl P male gonad development
GO:0010259 IEA:Ensembl P multicellular organismal aging
GO:2000195 IEA:Ensembl P negative regulation of female gonad development
GO:2000020 IEA:Ensembl P positive regulation of male gonad development
GO:0045944 IEA:Ensembl P positive regulation of transcription from RNA polymerase II promoter
GO:0009888 IEA:Ensembl P tissue development
GO:0006366 IMP:RGD P transcription from RNA polymerase II promoter

REACTOME Pathway Links

REACTOME Pathway ID Description
5953330 Gene Expression
5953833 Generic Transcription Pathway
5954147 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR016355 Steroidogenic_factor_1
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 5, group A, member 1
Protein Entry
STF1_RAT
UniProt ID
P50569
Species
Rat

Comments

Comment Type Description
Function Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (By similarity)
Ptm Acetylation stimulates the transcriptional activity
Ptm Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity)
Ptm Sumoylation reduces CDK7-mediated phosophorylation on Ser- 203
Similarity Belongs to the nuclear hormone receptor family. NR5 subfamily
Similarity Contains 1 nuclear receptor DNA-binding domain
Subcellular Location Nucleus.
Subunit Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with NR0B2, NCOA2 and PPARGC1A. Interacts with DGKQ and CDK7. Binds to and activated by HIPK3 (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012800 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
300797824 RefSeq NP_001178028 462 steroidogenic factor 1

Identical Sequences to LMP012800 proteins

Reference Database Accession Length Protein Name
GI:300797824 DBBJ BAA07722.1 462 Ad4BP [Rattus norvegicus]
GI:300797824 GenBank EDM00510.1 462 rCG37716, isoform CRA_a [Rattus norvegicus]
GI:300797824 SwissProt P50569.1 462 RecName: Full=Steroidogenic factor 1; Short=SF-1; Short=STF-1; AltName: Full=Adrenal 4-binding protein; AltName: Full=Fushi tarazu factor homolog 1; AltName: Full=Nuclear receptor subfamily 5 group A member 1; AltName: Full=Steroid hormone receptor Ad4BP [Rattus norvegicus]

Related Sequences to LMP012800 proteins

Reference Database Accession Length Protein Name
GI:300797824 DBBJ BAA07722.1 462 Ad4BP [Rattus norvegicus]
GI:300797824 GenBank EDM00510.1 462 rCG37716, isoform CRA_a [Rattus norvegicus]
GI:300797824 SwissProt P50569.1 462 RecName: Full=Steroidogenic factor 1; Short=SF-1; Short=STF-1; AltName: Full=Adrenal 4-binding protein; AltName: Full=Fushi tarazu factor homolog 1; AltName: Full=Nuclear receptor subfamily 5 group A member 1; AltName: Full=Steroid hormone receptor Ad4BP [Rattus norvegicus]