Gene/Proteome Database (LMPD)

LMPD ID
LMP012803
Gene ID
83842
Species
Rattus norvegicus (Rat)
Gene Name
carnitine O-octanoyltransferase
Gene Symbol
Crot
Alternate Names
peroxisomal carnitine O-octanoyltransferase; COT;
Chromosome
4
Map Location
4q12
EC Number
2.3.1.137;
Summary
catalyzes the conversion of L-carnitine and octanoyl-CoA to L-octanoylcarnitine and CoA; plays a role in fatty acid transport [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Crot

Proteins

peroxisomal carnitine O-octanoyltransferase
Refseq ID NP_114193
Protein GI 14010893
UniProt ID P11466
mRNA ID NM_031987
Length 612
MENQLAKSIEERTFQYQDSLPPLPVPSLEESLKKYLESVKPFANEDEYKKTEEIVQKFQDGVGKTLHQKLLERAKGKRNWLEEWWLNVAYLDVRIPSQLNVNFVGPSPHFEHYWPAREGTQLERGSILLWHNLNYWQLLRREKLPVHKSGNTPLDMNQFRMLFSTCKVPGITRDSIMNYFKTESEGHCPTHIAVLCRGRAFVFDVLHDGCLITPPELLRQLTYIYQKCWNEPVGPSIAALTSEERTRWAKAREYLIGLDPENLTLLEKIQSSLFVYSIEDTSPHATPENFSQVFEMLLGGDPAVRWGDKSYNLISFANGIFGCSCDHAPYDAMLMVNIAHYVDEKLLETEGRWKGSEKVRDIPLPEELAFTVDEKILNDVYQAKAQHLKAASDLQIAASTFTSFGKKLTKKEALHPDTFIQLALQLAYYRLHGRPGCCYETAMTRYFYHGRTETVRSCTVEAVRWCQSMQDPSASLLERQQKMLDAFAKHNKMMRDCSHGKGFDRHLLGLLLIAKEEGLPVPELFEDPLFSRSGGGGNFVLSTSLVGYLRIQGVVVPMVHNGYGFFYHIRDDRFVVTCSSWRSCLETDAEKLVEMIFHAFHDMIHLMNTAHL

Gene Information

Entrez Gene ID
83842
Gene Name
carnitine O-octanoyltransferase
Gene Symbol
Crot
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005777 IDA:RGD C peroxisome
GO:0008458 IDA:RGD F carnitine O-octanoyltransferase activity
GO:0009437 ISS:UniProtKB P carnitine metabolic process
GO:0015936 ISS:UniProtKB P coenzyme A metabolic process
GO:0006635 IEA:UniProtKB-UniPathway P fatty acid beta-oxidation
GO:0006631 ISS:UniProtKB P fatty acid metabolic process
GO:0006091 ISS:UniProtKB P generation of precursor metabolites and energy
GO:0015909 TAS:RGD P long-chain fatty acid transport
GO:0051791 ISS:UniProtKB P medium-chain fatty acid metabolic process
GO:0001579 TAS:RGD P medium-chain fatty acid transport
GO:0042493 IDA:RGD P response to drug
GO:0010243 IEP:RGD P response to organonitrogen compound

KEGG Pathway Links

KEGG Pathway ID Description
ko04146 Peroxisome
rno04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
5954181 Beta-oxidation of pristanoyl-CoA
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953470 Peroxisomal lipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000542 Acyltransferase ChoActase/COT/CPT

UniProt Annotations

Entry Information

Gene Name
carnitine O-octanoyltransferase
Protein Entry
OCTC_RAT
UniProt ID
P11466
Species
Rat

Comments

Comment Type Description
Catalytic Activity Octanoyl-CoA + L-carnitine = CoA + L- octanoylcarnitine.
Function Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Sequence Caution Sequence=AAA40948.1; Type=Frameshift; Positions=464; Evidence= ; Sequence=AAA40948.1; Type=Miscellaneous discrepancy; Evidence= ;
Similarity Belongs to the carnitine/choline acetyltransferase family
Subcellular Location Peroxisome .
Tissue Specificity Liver.

Identical and Related Proteins

Unique RefSeq proteins for LMP012803 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14010893 RefSeq NP_114193 612 peroxisomal carnitine O-octanoyltransferase

Identical Sequences to LMP012803 proteins

Reference Database Accession Length Protein Name
GI:14010893 GenBank AAC52317.1 612 carnitine octanoyltransferase [Rattus norvegicus]
GI:14010893 SwissProt P11466.3 612 RecName: Full=Peroxisomal carnitine O-octanoyltransferase; Short=COT [Rattus norvegicus]

Related Sequences to LMP012803 proteins

Reference Database Accession Length Protein Name
GI:14010893 GenBank AAC52317.1 612 carnitine octanoyltransferase [Rattus norvegicus]
GI:14010893 GenBank EDL84313.1 612 carnitine O-octanoyltransferase, isoform CRA_a [Rattus norvegicus]
GI:14010893 SwissProt P11466.3 612 RecName: Full=Peroxisomal carnitine O-octanoyltransferase; Short=COT [Rattus norvegicus]