Gene/Proteome Database (LMPD)

LMPD ID
LMP012806
Gene ID
84018
Species
Rattus norvegicus (Rat)
Gene Name
synaptojanin 2
Gene Symbol
Synj2
Alternate Names
synaptojanin-2; synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2; synaptic inositol-1,4,5-trisphosphate 5-phosphatase 2;
Chromosome
1
Map Location
1q11
EC Number
3.1.3.36
Summary
Inositol 5-phosphatase; may be involved in membrane trafficking and signal transduction pathways [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Synj2

Proteins

synaptojanin-2 isoform 1
Refseq ID NP_001106842
Protein GI 164565435
UniProt ID O55207
mRNA ID NM_001113371
Length 1496
MALSKGLRLLARLDPTGPSSVLLEARGRGDCLLFEAGAVATLAPEEKEVIKGLYGKPTDAYGCLGELSLKSGGVPLSFLVLVTGCTSVGRIPDAEIYKITGTEFYPLQEEAKEEDRLPALKKILSSGVFYFAWPNDGACFDLTIRAQKQGDDCSEWGTSFFWNQLLHVPLRQHQVNCHDWLLKVICGVVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQAIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKLENLLRPQLKLHWDDFGVFAKGENVSPRFQKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGLNSKPITDRFVESFKAMWSLNGHGLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTALLGLGSNKQNSLSGMLDGKATPRILKAMTERQSEFTNFKRIQIAMGTWNVNGGKQFRSNLLGTTELTDWLLDAPQLSGAVDSQDDGGPADIFAVGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLMEFDQLQLQKSSGKIFKDFHEGTINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLDSDLDGDANIRHTWSPGTLKYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSVQGPLDATVIVNLQSPTLEERNEFPEDLRTELMQTLGNYGTIILVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLEGLREELIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDVLEDDEDYLADEFGQPVVSDSELGGDDSSDTMSASTPASKSPALAKKKQHPTYKDDADLMTLKLELEVAGNFRHRSPSRSLSVPNRPRPPHPPQRPPPPTGLMVKKSASDASISSGTHGQYSILQTAKLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEAGGGVPESAPGATPLRNQGSSKPEASLGPPVLPRRPVPRVPTMKKPTLRRTGKPMLSEEQCEQQPVHFTMASQEMNLETPPPITAPIPPVPKPRTFQPGRGVERRPSGGKPEPDDAPPVTGAVELSSPEAPEAPSLAPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTCSSSSPSPPKPDTPLLYPQMALGTSSAISPETDGPRVTEPEAASFHGDYPDPFWSLLHHPKLLNNNTWLSKSSEPLDLGSRTPERTHTDSAQVNASVVERGLPPDHGGKDFSHWMAASNKDKRTTLGV
synaptojanin-2 isoform 2
Refseq ID NP_001106843
Protein GI 164565437
UniProt ID O55207
mRNA ID NM_001113372
Length 1451
MALSKGLRLLARLDPTGPSSVLLEARGRGDCLLFEAGAVATLAPEEKEVIKGLYGKPTDAYGCLGELSLKSGGVPLSFLVLVTGCTSVGRIPDAEIYKITGTEFYPLQEEAKEEDRLPALKKILSSGVFYFAWPNDGACFDLTIRAQKQGDDCSEWGTSFFWNQLLHVPLRQHQVNCHDWLLKVICGVVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQAIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKLENLLRPQLKLHWDDFGVFAKGENVSPRFQKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGLNSKPITDRFVESFKAMWSLNGHGLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTALLGLGSNKQNSLSGMLDGKATPRILKAMTERQSEFTNFKRIQIAMGTWNVNGGKQFRSNLLGTTELTDWLLDAPQLSGAVDSQDDGGPADIFAVGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLMEFDQLQLQKSSGKIFKDFHEGTINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLDSDLDGDANIRHTWSPGTLKYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSVQGPLDATVIVNLQSPTLEERNEFPEDLRTELMQTLGNYGTIILVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLEGLREELIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDVLEDDEDYLADEFGQPVVSDSELGGDDSSDTMSASTPASKSPALAKKKQHPTYKAGLMVKKSASDASISSGTHGQYSILQTAKLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEAGGGVPESAPGATPLRNQGSSKPEASLGPPVLPRRPVPRVPTMKKPTLRRTGKPMLSEEQCEQQPVHFTMASQEMNLETPPPITAPIPPVPKPRTFQPGRGVERRPSGGKPEPDDAPPVTGAVELSSPEAPEAPSLAPKVPPRRKKSAPAAFHLQVLQSNSQLLQGLTCSSSSPSPPKPDTPLLYPQMALGTSSAISPETDGPRVTEPEAASFHGDYPDPFWSLLHHPKLLNNNTWLSKSSEPLDLGSRTPERTHTDSAQVNASVVERGLPPDHGGKDFSHWMAASNKDKRTTLGV
synaptojanin-2 isoform 3
Refseq ID NP_114460
Protein GI 14091758
UniProt ID O55207
mRNA ID NM_032071
Length 1248
MALSKGLRLLARLDPTGPSSVLLEARGRGDCLLFEAGAVATLAPEEKEVIKGLYGKPTDAYGCLGELSLKSGGVPLSFLVLVTGCTSVGRIPDAEIYKITGTEFYPLQEEAKEEDRLPALKKILSSGVFYFAWPNDGACFDLTIRAQKQGDDCSEWGTSFFWNQLLHVPLRQHQVNCHDWLLKVICGVVTIRTVYASHKQAKACLISRISCERAGARFLTRGVNDDGHVSNFVETEQAIYMDDGVSSFVQIRGSVPLFWEQPGLQVGSHHLRLHRGLEANAPAFERHMVLLKEQYGQQVVVNLLGSRGGEEVLNRAFKKLLWASCHAGDTPMINFDFHQFAKGRKLEKLENLLRPQLKLHWDDFGVFAKGENVSPRFQKGTLRMNCLDCLDRTNTVQCFIALEVLHLQLESLGLNSKPITDRFVESFKAMWSLNGHGLSKVFTGSRALEGKAKVGKLKDGARSMSRTIQSNFFDGVKQEAIKLLLVGDVYNEESTDKGRMLLDNTALLGLGSNKQNSLSGMLDGKATPRILKAMTERQSEFTNFKRIQIAMGTWNVNGGKQFRSNLLGTTELTDWLLDAPQLSGAVDSQDDGGPADIFAVGFEEMVELSAGNIVNASTTNRKMWGEQLQKAISRSHRYILLTSAQLVGVCLYIFVRPYHVPFIRDVAIDTVKTGMGGKAGNKGAVGIRFQFHSTSFCFICSHLTAGQSQVKERNEDYREITHKLSFPSGRNIFSHDYVFWCGDFNYRIDLTYEEVFYFVKRQDWKKLMEFDQLQLQKSSGKIFKDFHEGTINFGPTYKYDVGSAAYDTSDKCRTPAWTDRVLWWRKKHPYDKTAGELNLLDSDLDGDANIRHTWSPGTLKYYGRAELQASDHRPVLAIVEVEVQEVDVGARERVFQEVSSVQGPLDATVIVNLQSPTLEERNEFPEDLRTELMQTLGNYGTIILVRINQGQMLVTFADSHSALSVLDVDGMKVKGRAVKIRPKTKDWLEGLREELIRKRDSMAPVSPTANSCLLEENFDFTSLDYESEGDVLEDDEDYLADEFGQPVVSDSELGGDDSSDTMSASTPASKSPALAKKKQHPTYKAGLMVKKSASDASISSGTHGQYSILQTAKLLPGAPQQPPKARTGISKPYNVKQIKTTNAQEAEAAIRCLLEAGGGVPESAPGATPLRNQGSSKPEASLGPPVLPRRPVPRVPTMKKPTLRRTGKIVFCSSSQASQPCSLLQRHEFVRTVAAQRLTPVDASGSSV

Gene Information

Entrez Gene ID
84018
Gene Name
synaptojanin 2
Gene Symbol
Synj2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0043679 IDA:RGD C axon terminus
GO:0005737 IDA:RGD C cytoplasm
GO:0005881 IDA:RGD C cytoplasmic microtubule
GO:0031315 IDA:RGD C extrinsic component of mitochondrial outer membrane
GO:0048471 IDA:RGD C perinuclear region of cytoplasm
GO:0032587 IDA:RGD C ruffle membrane
GO:0004445 IDA:RGD F inositol-polyphosphate 5-phosphatase activity
GO:0000166 IEA:InterPro F nucleotide binding
GO:0030165 IPI:RGD F PDZ domain binding
GO:0004439 IEA:UniProtKB-EC F phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0052744 IDA:RGD F phosphatidylinositol monophosphate phosphatase activity
GO:0003723 IEA:UniProtKB-KW F RNA binding
GO:0017124 IPI:RGD F SH3 domain binding
GO:0007420 IEP:RGD P brain development
GO:0046855 IDA:RGD P inositol phosphate dephosphorylation
GO:0048312 IDA:RGD P intracellular distribution of mitochondria
GO:0046856 IDA:RGD P phosphatidylinositol dephosphorylation

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

Domain Information

InterPro Annotations

Accession Description
IPR015047 Domain of unknown function DUF1866
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase
IPR012677 Nucleotide-binding alpha-beta plait domain
IPR000504 RNA recognition motif domain
IPR002013 SAC domain

UniProt Annotations

Entry Information

Gene Name
synaptojanin 2
Protein Entry
SYNJ2_RAT
UniProt ID
O55207
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=7; Comment=Additional isoforms seem to exist. Experimental confirmation may be lacking for some isoforms.; Name=2B2; IsoId=O55207-1; Sequence=Displayed; Name=2B1; IsoId=O55207-2; Sequence=VSP_012914; Name=2A; Synonyms=7.5kb; IsoId=O55207-3; Sequence=VSP_012915, VSP_012916; Note=The PDZ domain of isoform 2A binds SYNJ2BP/OMP25. Mutagenesis of Ser-1246 or Val-1248 to Ala abolishes SYNJ2BP/OMP25 binding.; Name=7.2kb; IsoId=O55207-4; Sequence=Not described; Name=6.0kb; IsoId=O55207-5; Sequence=Not described; Name=5.2kb; IsoId=O55207-6; Sequence=Not described; Name=3.5kb; IsoId=O55207-7; Sequence=Not described;
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.
Function Inositol 5-phosphatase which may be involved in distinct membrane trafficking and signal transduction pathways. May mediate the inhibitory effect of Rac1 on endocytosis (By similarity)
Interaction Q9WVJ4:Synj2bp; NbExp=9; IntAct=EBI-7007476, EBI-7007454;
Similarity Belongs to the synaptojanin family
Similarity Contains 1 RRM (RNA recognition motif) domain
Similarity Contains 1 SAC domain. {ECO:0000255|PROSITE- ProRule:PRU00183}.
Similarity In the central section; belongs to the inositol 1,4,5- trisphosphate 5-phosphatase family
Subcellular Location Cytoplasm . Cell membrane . Note=Rac1 causes translocation from cytosol to the plasma membrane.
Subcellular Location Isoform 2A: Mitochondrion. Note=Interaction of isoform 2A with SYNJ2BP/OMP25 results in localization to the mitochondrion.
Subunit Binds to GRB2 (By similarity). Isoform 2A binds to SYNJ2BP/OMP25
Tissue Specificity Widely expressed. Isoforms 2B1 and 2B2 are concentrated at nerve terminals in brain and at spermatid manchette in testis.

Identical and Related Proteins

Unique RefSeq proteins for LMP012806 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
164565435 RefSeq NP_001106842 1496 synaptojanin-2 isoform 1
164565437 RefSeq NP_001106843 1451 synaptojanin-2 isoform 2
14091758 RefSeq NP_114460 1248 synaptojanin-2 isoform 3

Identical Sequences to LMP012806 proteins

Reference Database Accession Length Protein Name
GI:14091758 GenBank AAB92481.1 1248 synaptojanin II [Rattus norvegicus]

Related Sequences to LMP012806 proteins

Reference Database Accession Length Protein Name
GI:164565435 EMBL CAR81447.1 1496 unnamed protein product [Rattus norvegicus]
GI:14091758 GenBank AAB92481.1 1248 synaptojanin II [Rattus norvegicus]
GI:164565437 GenBank AAK61722.1 1451 synaptojanin 2B1 [Rattus norvegicus]
GI:14091758 GenBank EDL83728.1 1248 synaptojanin 2, isoform CRA_b [Rattus norvegicus]
GI:164565435 GenBank EDL83729.1 1496 synaptojanin 2, isoform CRA_c [Rattus norvegicus]
GI:164565437 GenBank EDL83732.1 1451 synaptojanin 2, isoform CRA_f [Rattus norvegicus]
GI:164565437 RefSeq NP_001106842.1 1496 synaptojanin-2 isoform 1 [Rattus norvegicus]
GI:14091758 RefSeq NP_001106843.1 1451 synaptojanin-2 isoform 2 [Rattus norvegicus]
GI:164565435 SwissProt O55207.2 1496 RecName: Full=Synaptojanin-2; AltName: Full=Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2 [Rattus norvegicus]