Gene/Proteome Database (LMPD)

LMPD ID
LMP012807
Gene ID
84023
Species
Rattus norvegicus (Rat)
Gene Name
prostaglandin E receptor 4 (subtype EP4)
Gene Symbol
Ptger4
Synonyms
EP4; Ptger; Ptgerep4;
Alternate Names
prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; prostaglandin E2 receptor type 4;
Chromosome
2
Map Location
2q16
Summary
binds prostaglandin estradiol (PGE(2)) and induces cAMP-dependent bone resorption [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ptger4

Proteins

prostaglandin E2 receptor EP4 subtype
Refseq ID NP_114465
Protein GI 148747241
UniProt ID P43114
mRNA ID NM_032076
Length 488
MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAAAVASVACRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQLYQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRDGSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSQTLLYLPDLTESSLGGKNLLPGTHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSETLKLSEKCI

Gene Information

Entrez Gene ID
84023
Gene Name
prostaglandin E receptor 4 (subtype EP4)
Gene Symbol
Ptger4
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0004957 ISS:UniProtKB F prostaglandin E receptor activity
GO:0070371 IDA:UniProtKB P ERK1 and ERK2 cascade
GO:0007254 IDA:UniProtKB P JNK cascade
GO:0042093 ISS:UniProtKB P T-helper cell differentiation
GO:0007188 ISS:UniProtKB P adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0060348 IDA:UniProtKB P bone development
GO:0071260 ISS:UniProtKB P cellular response to mechanical stimulus
GO:0050710 ISS:UniProtKB P negative regulation of cytokine secretion
GO:2000420 ISS:UniProtKB P negative regulation of eosinophil extravasation
GO:0050728 ISS:UniProtKB P negative regulation of inflammatory response
GO:0033624 ISS:UniProtKB P negative regulation of integrin activation
GO:0050715 ISS:UniProtKB P positive regulation of cytokine secretion
GO:0050729 ISS:UniProtKB P positive regulation of inflammatory response
GO:0030278 IEA:Ensembl P regulation of ossification
GO:0051492 ISS:UniProtKB P regulation of stress fiber assembly
GO:0032496 IEA:Ensembl P response to lipopolysaccharide

KEGG Pathway Links

KEGG Pathway ID Description
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954202 Eicosanoid ligand-binding receptors
5953755 G alpha (s) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5954201 Prostanoid ligand receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR001244 Prostaglandin DP receptor
IPR001758 Prostanoid EP4 receptor
IPR008365 Prostanoid receptor

UniProt Annotations

Entry Information

Gene Name
prostaglandin E receptor 4 (subtype EP4)
Protein Entry
PE2R4_RAT
UniProt ID
P43114
Species
Rat

Comments

Comment Type Description
Caution Was originally designated as the EP2 subtype
Function Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Ptm Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane; Multi-pass membrane protein.
Subunit Interacts with FEM1A

Identical and Related Proteins

Unique RefSeq proteins for LMP012807 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
148747241 RefSeq NP_114465 488 prostaglandin E2 receptor EP4 subtype

Identical Sequences to LMP012807 proteins

Reference Database Accession Length Protein Name
GI:148747241 GenBank AAB53326.1 488 EP4 prostanoid receptor [Rattus norvegicus]
GI:148747241 GenBank EDL75721.1 488 prostaglandin E receptor 4 (subtype EP4), isoform CRA_b [Rattus norvegicus]
GI:148747241 RefSeq XP_006232058.1 488 PREDICTED: prostaglandin E2 receptor EP4 subtype isoform X1 [Rattus norvegicus]

Related Sequences to LMP012807 proteins

Reference Database Accession Length Protein Name
GI:148747241 GenBank AAB53326.1 488 EP4 prostanoid receptor [Rattus norvegicus]
GI:148747241 GenBank EDL75721.1 488 prostaglandin E receptor 4 (subtype EP4), isoform CRA_b [Rattus norvegicus]
GI:148747241 RefSeq XP_006232058.1 488 PREDICTED: prostaglandin E2 receptor EP4 subtype isoform X1 [Rattus norvegicus]