Gene/Proteome Database (LMPD)
LMPD ID
LMP012808
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
paraoxonase 1
Gene Symbol
Alternate Names
serum paraoxonase/arylesterase 1; PON 1; A-esterase 1; aromatic esterase 1; serum aryldialkylphosphatase 1;
Chromosome
4
Map Location
4q13
EC Number
3.1.1.2
Summary
may protect LDL and HDL from oxidation and provide protection against atherosclerosis [RGD, Feb 2006]
Orthologs
Proteins
| serum paraoxonase/arylesterase 1 precursor | |
|---|---|
| Refseq ID | NP_114466 |
| Protein GI | 54292130 |
| UniProt ID | P55159 |
| mRNA ID | NM_032077 |
| Length | 355 |
| MAKLLGLTLVGLVLALYKNHRSSYQTRLNAFREVTPVDLPNCTLVKGIEAGAEDLEILPNGLTFFSTGLKYPGIKSFDPSKPGKILLMDLNEKEPAVSELAIMGNTLDMSSFNPHGISTFIDEDNTVYLLVVSHPDSSSTVEVFKFQEEERSLLHLKTITHELLPSINDIAAVGPESFYATNDHYFADPYLRSWEMYLGLSWSNVVYYSPDKVRVVADGFDFANGIGISLDGKYVYIAELLAHKIHVYEKHANWTLTPLKVLSFDTLVDNISVDPVTGDLWVGCHPNGMRIFFYDSENPPGSEVLRIQSILSEDPKVTVVYAENGTVLQGTTVAAVYKGKLLIGTVFHRALCCDL | |
| sig_peptide: 1..15 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1512 peptide sequence: MAKLLGLTLVGLVLA | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0072562 | IEA:Ensembl | C | blood microparticle |
| GO:0005615 | IDA:RGD | C | extracellular space |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0043231 | IDA:RGD | C | intracellular membrane-bounded organelle |
| GO:0034366 | IEA:Ensembl | C | spherical high-density lipoprotein particle |
| GO:0004063 | ISS:UniProtKB | F | aryldialkylphosphatase activity |
| GO:0004064 | ISS:UniProtKB | F | arylesterase activity |
| GO:0005509 | ISS:UniProtKB | F | calcium ion binding |
| GO:0005543 | IEA:Ensembl | F | phospholipid binding |
| GO:0019439 | IEA:Ensembl | P | aromatic compound catabolic process |
| GO:0046395 | IEA:Ensembl | P | carboxylic acid catabolic process |
| GO:0016311 | IDA:GOC | P | dephosphorylation |
| GO:0006629 | IEP:RGD | P | lipid metabolic process |
| GO:0046434 | IEA:Ensembl | P | organophosphate catabolic process |
| GO:0046470 | IEA:Ensembl | P | phosphatidylcholine metabolic process |
| GO:0051099 | IEA:Ensembl | P | positive regulation of binding |
| GO:0010875 | IEA:Ensembl | P | positive regulation of cholesterol efflux |
| GO:0032411 | IEA:Ensembl | P | positive regulation of transporter activity |
| GO:0070542 | IEP:RGD | P | response to fatty acid |
| GO:1902617 | IDA:RGD | P | response to fluoride |
| GO:0031667 | IEP:RGD | P | response to nutrient levels |
| GO:0009636 | IEA:Ensembl | P | response to toxic substance |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| rno01100 | Metabolic pathways |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | A phenyl acetate + H(2)O = a phenol + acetate. |
| Catalytic Activity | An N-acyl-L-homoserine lactone + H(2)O = an N- acyl-L-homoserine. |
| Catalytic Activity | An aryl dialkyl phosphate + H(2)O = dialkyl phosphate + an aryl alcohol. |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 2 calcium ions per subunit. ; |
| Function | Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification (By similarity) |
| Miscellaneous | The preferential association of PON1 with HDL is mediated in part by its signal peptide, by binding phospholipids directly, rather than binding apo AI. The retained signal peptide may allow transfer of the protein between phospholipid surfaces (By similarity) |
| Ptm | Glycosylated |
| Ptm | The signal sequence is not cleaved. |
| Similarity | Belongs to the paraoxonase family |
| Subcellular Location | Secreted, extracellular space. |
| Subunit | Homodimer. Interacts with CLU (By similarity) |
| Tissue Specificity | Plasma. Associated with HDL. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012808 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 54292130 | RefSeq | NP_114466 | 355 | serum paraoxonase/arylesterase 1 precursor |
Identical Sequences to LMP012808 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:54292130 | GenBank | AAH91403.1 | 355 | Paraoxonase 1 [Rattus norvegicus] |
| GI:54292130 | GenBank | EDM15017.1 | 355 | paraoxonase 1, isoform CRA_a [Rattus norvegicus] |
| GI:54292130 | SwissProt | P55159.3 | 355 | RecName: Full=Serum paraoxonase/arylesterase 1; Short=PON 1; AltName: Full=Aromatic esterase 1; Short=A-esterase 1; AltName: Full=Serum aryldialkylphosphatase 1 [Rattus norvegicus] |
Related Sequences to LMP012808 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:54292130 | GenBank | AAH91403.1 | 355 | Paraoxonase 1 [Rattus norvegicus] |
| GI:54292130 | GenBank | EDM15017.1 | 355 | paraoxonase 1, isoform CRA_a [Rattus norvegicus] |
| GI:54292130 | SwissProt | P55159.3 | 355 | RecName: Full=Serum paraoxonase/arylesterase 1; Short=PON 1; AltName: Full=Aromatic esterase 1; Short=A-esterase 1; AltName: Full=Serum aryldialkylphosphatase 1 [Rattus norvegicus] |