Gene/Proteome Database (LMPD)

LMPD ID
LMP012809
Gene ID
84028
Species
Rattus norvegicus (Rat)
Gene Name
pancreatic lipase-related protein 1
Gene Symbol
Pnliprp1
Alternate Names
inactive pancreatic lipase-related protein 1; PL-RP1; pancreatic lipase related protein 1;
Chromosome
1
Map Location
1q55
Summary
hydrolyzes dietary triacylglycerols in the duodenum; may play a role in fat metabolism [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pnliprp1

Proteins

inactive pancreatic lipase-related protein 1 precursor
Refseq ID NP_114470
Protein GI 14091772
UniProt ID P54316
mRNA ID NM_032081
Length 473
MLTLWTVSLFLLGAAQGKEVCYDNLGCFSDAEPWAGTAIRPLKLLPWSPEKINTRFLLYTNENPTAFQTLQLSDPLTIGASNFQVARKTRFIIHGFIDKGEENWVVDMCKNMFQVEEVNCICVDWKKGSQTTYTQAANNVRVVGAQVAQMIDILVKNYSYSPSKVHLIGHSLGAHVAGEAGSRTPGLGRITGLDPVEANFEGTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQMSGHLDFFPNGGQSMPGCKKNALSQIVDIDGIWSGTRDFVACNHLRSYKYYLESILNPDGFAAYPCASYKDFESNKCFPCPDQGCPQMGHYADKFAGKSGDEPQKFFLNTGEAKNFARWRYRVSLILSGRMVTGQVKVALFGSKGNTRQYDIFRGIIKPGATHSSEFDAKLDVGTIEKVKFLWNNQVINPSFPKVGAAKITVQKGEERTEYNFCSEETVREDTLLTLLPCETSDTV
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1821 peptide sequence: MLTLWTVSLFLLGAAQG mat_peptide: 18..473 product: inactive pancreatic lipase-related protein 1 calculated_mol_wt: 50576 peptide sequence: KEVCYDNLGCFSDAEPWAGTAIRPLKLLPWSPEKINTRFLLYTNENPTAFQTLQLSDPLTIGASNFQVARKTRFIIHGFIDKGEENWVVDMCKNMFQVEEVNCICVDWKKGSQTTYTQAANNVRVVGAQVAQMIDILVKNYSYSPSKVHLIGHSLGAHVAGEAGSRTPGLGRITGLDPVEANFEGTPEEVRLDPSDADFVDVIHTDAAPLIPFLGFGTNQMSGHLDFFPNGGQSMPGCKKNALSQIVDIDGIWSGTRDFVACNHLRSYKYYLESILNPDGFAAYPCASYKDFESNKCFPCPDQGCPQMGHYADKFAGKSGDEPQKFFLNTGEAKNFARWRYRVSLILSGRMVTGQVKVALFGSKGNTRQYDIFRGIIKPGATHSSEFDAKLDVGTIEKVKFLWNNQVINPSFPKVGAAKITVQKGEERTEYNFCSEETVREDTLLTLLPCETSDTV

Gene Information

Entrez Gene ID
84028
Gene Name
pancreatic lipase-related protein 1
Gene Symbol
Pnliprp1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005615 IDA:RGD C extracellular space
GO:0005509 ISS:UniProtKB F calcium ion binding
GO:0016298 IDA:RGD F lipase activity
GO:0004806 IEA:InterPro F triglyceride lipase activity
GO:0006629 IEA:InterPro P lipid metabolic process
GO:0031016 IEP:RGD P pancreas development
GO:0051384 IEP:RGD P response to glucocorticoid
GO:0043434 IEP:RGD P response to peptide hormone

KEGG Pathway Links

KEGG Pathway ID Description
M00098 Acylglycerol degradation
ko04975 Fat digestion and absorption
rno04975 Fat digestion and absorption
ko00561 Glycerolipid metabolism
rno00561 Glycerolipid metabolism
rno01100 Metabolic pathways
ko04972 Pancreatic secretion
rno04972 Pancreatic secretion

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013818 Lipase, N-terminal
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR016272 Lipoprotein_lipase_LIPH
IPR001024 PLAT/LH2 domain
IPR002331 Pancreatic lipase
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
pancreatic lipase-related protein 1
Protein Entry
LIPR1_RAT
UniProt ID
P54316
Species
Rat

Comments

Comment Type Description
Caution Was originally thought to be the pancreatic lipase
Function May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity (in vitro) (By similarity)
Similarity Belongs to the AB hydrolase superfamily. Lipase family
Similarity Contains 1 PLAT domain. {ECO:0000255|PROSITE- ProRule:PRU00152}.
Subcellular Location Secreted .

Identical and Related Proteins

Unique RefSeq proteins for LMP012809 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
14091772 RefSeq NP_114470 473 inactive pancreatic lipase-related protein 1 precursor

Identical Sequences to LMP012809 proteins

Reference Database Accession Length Protein Name
GI:14091772 EMBL CAA43927.1 473 triacylglycerol lipase [Rattus norvegicus]
GI:14091772 GenBank AAP66258.1 473 Sequence 8 from patent US 6558936
GI:14091772 SwissProt P54316.1 473 RecName: Full=Inactive pancreatic lipase-related protein 1; Short=PL-RP1; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012809 proteins

Reference Database Accession Length Protein Name
GI:14091772 EMBL CAA43927.1 473 triacylglycerol lipase [Rattus norvegicus]
GI:14091772 GenBank AAP66258.1 473 Sequence 8 from patent US 6558936
GI:14091772 SwissProt P54316.1 473 RecName: Full=Inactive pancreatic lipase-related protein 1; Short=PL-RP1; Flags: Precursor [Rattus norvegicus]