Gene/Proteome Database (LMPD)
LMPD ID
LMP012810
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
ectonucleotide pyrophosphatase/phosphodiesterase 2
Gene Symbol
Alternate Names
ectonucleotide pyrophosphatase/phosphodiesterase family member 2; E-NPP 2; lysoPLD; autotaxin; extracellular lysophospholipase D; phosphodiesterase I/nucleotide pyrophosphatase 2 (autotaxin);
Chromosome
7
Map Location
7q31
EC Number
3.1.4.39
Summary
may regulate oligodendrocyte cell-extracellular matrix adhesive interactions during myelination [RGD, Feb 2006]
Orthologs
Proteins
| ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | |
|---|---|
| Refseq ID | NP_476445 |
| Protein GI | 86439949 |
| UniProt ID | Q64610 |
| mRNA ID | NM_057104 |
| Length | 862 |
| MARQGCLGSFQVISLFTFAISVNICLGFTASRIKRAEWDEGPPTVLSDSPWTNTSGSCKGRCFELQEVGPPDCRCDNLCKSYSSCCHDFDELCLKTARGWECTKDRCGEVRNEENACHCSEDCLSRGDCCTNYQVVCKGESHWVDDDCEEIKVPECPAGFVRPPLIIFSVDGFRASYMKKGSKVMPNIEKLRSCGTHAPYMRPVYPTKTFPNLYTLATGLYPESHGIVGNSMYDPVFDASFHLRGREKFNHRWWGGQPLWITATKQGVRAGTFFWSVSIPHERRILTILQWLSLPDNERPSVYAFYSEQPDFSGHKYGPFGPEMTNPLREIDKTVGQLMDGLKQLRLHRCVNVIFVGDHGMEDVTCDRTEFLSNYLTNVDDITLVPGTLGRIRAKSINNSKYDPKTIIANLTCKKPDQHFKPYMKQHLPKRLHYANNRRIEDIHLLVDRRWHVARKPLDVYKKPSGKCFFQGDHGFDNKVNSMQTVFVGYGPTFKYRTKVPPFENIELYNVMCDLLGLKPAPNNGTHGSLNHLLRTNTFRPTMPDEVSRPNYPGIMYLQSEFDLGCTCDDKVEPKNKLEELNKRLHTKGSTEERHLLYGRPAVLYRTSYDILYHTDFESGYSEIFLMPLWTSYTISKQAEVSSIPEHLTNCVRPDVRVSPGFSQNCLAYKNDKQMSYGFLFPPYLSSSPEAKYDAFLVTNMVPMYPAFKRVWAYFQRVLVKKYASERNGVNVISGPIFDYNYDGLRDTEDEIKQYVEGSSIPVPTHYYSIITSCLDFTQPADKCDGPLSVSSFILPHRPDNDESCNSSEDESKWVEELMKMHTARVRDIEHLTGLDFYRKTSRSYSEILTLKTYLHTYESEI | |
Gene Information
Entrez Gene ID
Gene Name
ectonucleotide pyrophosphatase/phosphodiesterase 2
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005615 | IDA:UniProtKB | C | extracellular space |
| GO:0047391 | IEA:UniProtKB-EC | F | alkylglycerophosphoethanolamine phosphodiesterase activity |
| GO:0005509 | IDA:UniProtKB | F | calcium ion binding |
| GO:0004622 | IDA:UniProtKB | F | lysophospholipase activity |
| GO:0003676 | IEA:InterPro | F | nucleic acid binding |
| GO:0030247 | IEA:InterPro | F | polysaccharide binding |
| GO:0005044 | IEA:InterPro | F | scavenger receptor activity |
| GO:0008270 | IDA:UniProtKB | F | zinc ion binding |
| GO:0006935 | IEA:UniProtKB-KW | P | chemotaxis |
| GO:0006955 | IEA:InterPro | P | immune response |
| GO:0034638 | IDA:UniProtKB | P | phosphatidylcholine catabolic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR017849 | Alkaline phosphatase-like, alpha/beta/alpha |
| IPR017850 | Alkaline-phosphatase-like, core domain |
| IPR001604 | DNA/RNA_non-sp_Endonuclease |
| IPR024873 | Ectonucleotide pyrophosphatase/phosphodiesterase family |
| IPR020821 | Extracellular_endonuc_su_A |
| IPR001212 | Somatomedin B domain |
| IPR020436 | Somatomedin_B_chordata |
| IPR002591 | Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase |
UniProt Annotations
Entry Information
Gene Name
ectonucleotide pyrophosphatase/phosphodiesterase 2
Protein Entry
ENPP2_RAT
UniProt ID
Species
Rat
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q64610-1; Sequence=Displayed; Name=2; IsoId=Q64610-2; Sequence=VSP_024018; Note=No experimental confirmation available.; |
| Catalytic Activity | 1-alkyl-sn-glycero-3-phosphoethanolamine + H(2)O = 1-alkyl-sn-glycerol 3-phosphate + ethanolamine |
| Cofactor | Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 1 Ca(2+) ion per subunit. ; |
| Cofactor | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence= ; Note=Binds 2 Zn(2+) ions per subunit. ; |
| Enzyme Regulation | Inhibited by lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P). Inhibited by EDTA and EGTA (By similarity) |
| Function | Hydrolyzes lysophospholipids to produce lysophosphatidic acid (LPA) in extracellular fluids. Major substrate is lysophosphatidylcholine. Also can act on sphingosylphosphphorylcholine producing sphingosine-1-phosphate, a modulator of cell motility. Can hydrolyze, in vitro, bis-pNPP, to some extent pNP-TMP, and barely ATP. Involved in several motility- related processes such as angiogenesis and neurite outgrowth. Acts as an angiogenic factor by stimulating migration of smooth muscle cells and microtubule formation. Stimulates migration of melanoma cells, probably via a pertussis toxin-sensitive G protein. May have a role in induction of parturition. Possible involvement in cell proliferation and adipose tissue development. Tumor cell motility-stimulating factor. {ECO:0000269|PubMed:12119361, ECO:0000269|PubMed:15985467}. |
| Ptm | N-glycosylation, but not furin-cleavage, plays a critical role on secretion and on lysoPLD activity |
| Similarity | Belongs to the nucleotide pyrophosphatase/phosphodiesterase family |
| Similarity | Contains 2 SMB (somatomedin-B) domains |
| Subcellular Location | Secreted {ECO:0000269|PubMed:12119361, ECO:0000269|PubMed:12633853, ECO:0000269|PubMed:15985467, ECO:0000269|PubMed:16436050, ECO:0000269|PubMed:21240271}. Note=Secreted by most body fluids including serum and CSF. Also by adipocytes and numerous cancer cells. |
| Tissue Specificity | Abundantly expressed in cerebrum and cerebellum. Localized in secretory epithelial cells in the brain and the eye including choroid plexus epithelial cells, ciliary epithelial cells, iris pigment epithelial cells, and retinal pigment cells. {ECO:0000269|PubMed:16436050, ECO:0000269|PubMed:7961762}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012810 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 86439949 | RefSeq | NP_476445 | 862 | ectonucleotide pyrophosphatase/phosphodiesterase family member 2 |
Identical Sequences to LMP012810 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:86439949 | GenBank | AAH81747.1 | 862 | Ectonucleotide pyrophosphatase/phosphodiesterase 2 [Rattus norvegicus] |
| GI:86439949 | GenBank | AAZ99725.1 | 862 | autotaxin [Rattus norvegicus] |
| GI:86439949 | GenBank | EDM16260.1 | 862 | rCG59939, isoform CRA_c [Rattus norvegicus] |
Related Sequences to LMP012810 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:86439949 | GenBank | AAH81747.1 | 862 | Ectonucleotide pyrophosphatase/phosphodiesterase 2 [Rattus norvegicus] |
| GI:86439949 | GenBank | AAZ99725.1 | 862 | autotaxin [Rattus norvegicus] |
| GI:86439949 | GenBank | EDM16260.1 | 862 | rCG59939, isoform CRA_c [Rattus norvegicus] |