Gene/Proteome Database (LMPD)

LMPD ID
LMP012814
Gene ID
84470
Species
Rattus norvegicus (Rat)
Gene Name
glyceronephosphate O-acyltransferase
Gene Symbol
Gnpat
Alternate Names
dihydroxyacetone phosphate acyltransferase; DAP-AT; DHAP-AT; glycerone-phosphate O-acyltransferase; acyl-CoA:dihydroxyacetonephosphateacyltransferase; acyl-CoA:dihydroxyacetonephosphate acyltransferase;
Chromosome
19
Map Location
19q12
EC Number
2.3.1.42
Summary
catalyzes the transesterification of dihydroxyacetone phosphate (DHAP) to form acyl-DHAP by utilizing long-chain acyl coenzyme As (CoAs) as acyl donors involved in plasmalogen biosynthesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Gnpat

Proteins

dihydroxyacetone phosphate acyltransferase
Refseq ID NP_445862
Protein GI 16758146
UniProt ID Q9ES71
mRNA ID NM_053410
Length 678
MDVPSSSSSRFSVGSASPSSVLLYAKDLKKWDEFEDLLEERRQVSDFKFAMKCYTPPLYRGITPCKPSDIKSIVLNSEEINYVIKQLSRESLTGVDVLREEANEILEEMSHKLRIGAIRFFAFVLSKVFKQIFSKVCVNEEGIQKLQRAIQEHPVILLPSHRSYIDFLMLSFVLYNYDLPVPVIAAGMDFLGMRVVSELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRSGYAPVEFFLEGTRSRAAKTLTPKFGLLNIVMEPFFKREVFDTYFVPISISYDKILEESLYAYELLGIPKPKESTTGLLKARRILSENFGSIHVYFGDPVSLRSLAAGRLSRNTYNLVPRCIPQKQPEDVQAFVTEVAYKMQLLQIENLALSPWLLVVAILLQNQLCMDFDALVEKTLWLKGLTQVFGGFLLWPDNKLPEEVVQSSILLHSNLATLVKDQVVLKVDSESSQMVNGLVPQHIAFLMCSAYRNQLLNVFARPSLVAVALHMTPGLRKEDVFSCFSFLRNVFSDEFIFLPGNTLRDFEEGCYLLCKTEVMQMTGKDIILTDKGNAVLQFLTGLFKPFVESYQILSKCLLHEEDYFSEKEYLVTARKFTRQLLDQDASQCYDALSSELQKNALAAFVRLGVVEKNKVDSKYVYYVNGPATSKLEEMLGCKKPIGKPATAKL

Gene Information

Entrez Gene ID
84470
Gene Name
glyceronephosphate O-acyltransferase
Gene Symbol
Gnpat
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:RGD C mitochondrion
GO:0005778 IDA:UniProtKB C peroxisomal membrane
GO:0005777 IDA:HGNC C peroxisome
GO:0016287 TAS:RGD F glycerone-phosphate O-acyltransferase activity
GO:0016290 IEA:Ensembl F palmitoyl-CoA hydrolase activity
GO:0021587 IEA:Ensembl P cerebellum morphogenesis
GO:0008611 IEA:Ensembl P ether lipid biosynthetic process
GO:0006650 IEA:UniProtKB-UniPathway P glycerophospholipid metabolic process
GO:0061024 IEA:Ensembl P membrane organization
GO:0030913 IEA:Ensembl P paranodal junction assembly
GO:0042493 IEP:RGD P response to drug
GO:0070542 IEP:RGD P response to fatty acid
GO:0007584 IEP:RGD P response to nutrient
GO:0042594 IEP:RGD P response to starvation
GO:0007416 IEA:Ensembl P synapse assembly

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
ko04146 Peroxisome
rno04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953470 Peroxisomal lipid metabolism
5953474 Phospholipid metabolism
5953469 Plasmalogen biosynthesis
5953472 Synthesis of PA

Domain Information

InterPro Annotations

Accession Description
IPR028353 Dihydroxyacetone phosphate acyltransferase
IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
glyceronephosphate O-acyltransferase
Protein Entry
GNPAT_RAT
UniProt ID
Q9ES71
Species
Rat

Comments

Comment Type Description
Catalytic Activity Acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate.
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate
Pathway Membrane lipid metabolism; glycerophospholipid metabolism.
Similarity Belongs to the GPAT/DAPAT family
Subcellular Location Peroxisome membrane ; Peripheral membrane protein ; Matrix side . Note=Exclusively localized to the lumenal side of the peroxisomal membrane
Subunit May be part of a heterotrimeric complex composed of DAP- AT, ADAP-S and a modified form of DAP-AT

Identical and Related Proteins

Unique RefSeq proteins for LMP012814 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758146 RefSeq NP_445862 678 dihydroxyacetone phosphate acyltransferase

Identical Sequences to LMP012814 proteins

Reference Database Accession Length Protein Name
GI:16758146 GenBank AAG17548.1 678 acyl-CoA:dihydroxyacetonephosphate acyltransferase [Rattus norvegicus]
GI:16758146 GenBank EDL96743.1 678 glyceronephosphate O-acyltransferase, isoform CRA_a [Rattus norvegicus]
GI:16758146 SwissProt Q9ES71.1 678 RecName: Full=Dihydroxyacetone phosphate acyltransferase; Short=DAP-AT; Short=DHAP-AT; AltName: Full=Acyl-CoA:dihydroxyacetonephosphateacyltransferase; AltName: Full=Glycerone-phosphate O-acyltransferase [Rattus norvegicus]

Related Sequences to LMP012814 proteins

Reference Database Accession Length Protein Name
GI:16758146 GenBank AAG17548.1 678 acyl-CoA:dihydroxyacetonephosphate acyltransferase [Rattus norvegicus]
GI:16758146 GenBank EDL96743.1 678 glyceronephosphate O-acyltransferase, isoform CRA_a [Rattus norvegicus]
GI:16758146 SwissProt Q9ES71.1 678 RecName: Full=Dihydroxyacetone phosphate acyltransferase; Short=DAP-AT; Short=DHAP-AT; AltName: Full=Acyl-CoA:dihydroxyacetonephosphateacyltransferase; AltName: Full=Glycerone-phosphate O-acyltransferase [Rattus norvegicus]