Gene/Proteome Database (LMPD)
LMPD ID
LMP012818
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
fatty acid desaturase 1
Gene Symbol
Alternate Names
fatty acid desaturase 1; D5D; delta-5 desaturase; delta(5) desaturase; delta(5) fatty acid desaturase;
Chromosome
1
Map Location
1q43
EC Number
1.14.19.-
Summary
catalyzes the Delta(5,6) desaturation of fatty acids of the n-6 and n-3 series [RGD, Feb 2006]
Orthologs
Proteins
| fatty acid desaturase 1 | |
|---|---|
| Refseq ID | NP_445897 |
| Protein GI | 162287208 |
| UniProt ID | Q920R3 |
| mRNA ID | NM_053445 |
| Length | 447 |
| MAPDPVQTPDPASAQLRQMRYFTWEEVAQRSGREKERWLVIDRKVYNISDFSRRHPGGSRVISHYAGQDATDPFVAFHINKGLVRKYMNSLLIGELAPEQPSFEPTKNKALTDEFRELRATVERMGLMKANHLFFLFYLLHILLLDVAAWLTLWIFGTSLVPFTLCAVLLSTVQAQAGWLQHDFGHLSVFSTSTWNHLVHHFVIGHLKGAPASWWNHMHFQHHAKPNCFRKDPDINMHPLFFALGKVLSVELGKEKKKHMPYNHQHKYFFLIGPPALLPLYFQWYIFYFVVQRKKWVDLAWMLSFYVRVFFTYMPLLGLKGLLCLFFIVRFLESNWFVWVTQMNHIPMHIDHDRNVDWVSTQLQATCNVHQSAFNNWFSGHLNFQIEHHLFPTMPRHNYHKVAPLVQSLCAKYGIKYESKPLLTAFADIVYSLKESGQLWLDAYLHQ | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IEA:UniProtKB-KW | C | endoplasmic reticulum |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0043231 | IDA:RGD | C | intracellular membrane-bounded organelle |
| GO:0005739 | IEA:UniProtKB-KW | C | mitochondrion |
| GO:0005634 | IDA:RGD | C | nucleus |
| GO:0020037 | IEA:InterPro | F | heme binding |
| GO:0005506 | IEA:InterPro | F | iron ion binding |
| GO:0016717 | IDA:RGD | F | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water |
| GO:0007568 | IEP:RGD | P | aging |
| GO:0019369 | IMP:RGD | P | arachidonic acid metabolic process |
| GO:0009267 | IEA:Ensembl | P | cellular response to starvation |
| GO:0032868 | IEP:RGD | P | response to insulin |
| GO:0035900 | IEP:RGD | P | response to isolation stress |
| GO:0007584 | IEP:RGD | P | response to nutrient |
| GO:0014070 | IEP:RGD | P | response to organic cyclic compound |
| GO:0010033 | IEP:RGD | P | response to organic substance |
| GO:0009744 | IEP:RGD | P | response to sucrose |
| GO:0033189 | IEP:RGD | P | response to vitamin A |
| GO:0006636 | IDA:RGD | P | unsaturated fatty acid biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| ko01040 | Biosynthesis of unsaturated fatty acids |
| rno01040 | Biosynthesis of unsaturated fatty acids |
| ko01212 | Fatty acid metabolism |
| rno01212 | Fatty acid metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| 5953288 | Fatty acid, triacylglycerol, and ketone body metabolism |
| 5954541 | Linoleic acid (LA) metabolism |
| 5953250 | Metabolism |
| 5953289 | Metabolism of lipids and lipoproteins |
| 5954333 | PPARA activates gene expression |
| 5954222 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| 5954542 | alpha-linolenic (omega3) and linoleic (omega6) acid metabolism |
| 5954543 | alpha-linolenic acid (ALA) metabolism |
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Domain | The histidine box domains may contain the active site and/or be involved in metal ion binding. |
| Function | Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the desaturation of dihomo-gamma-linoleic acid (DHGLA) (20:3n-6) and eicosatetraenoic acid (20:4n-3) to generate arachidonic acid (AA) (20:4n-6) and eicosapentaenoic acid (EPA)(20:5n-3) respectively (By similarity) |
| Induction | Regulated by dietary vitamin A and exogenous retinoic acid in liver |
| Pathway | Lipid metabolism; polyunsaturated fatty acid biosynthesis. |
| Similarity | Belongs to the fatty acid desaturase family |
| Similarity | Contains 1 cytochrome b5 heme-binding domain |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein . Mitochondrion . |
| Tissue Specificity | Highly abundant in adrenal gland and mammary tissue and moderately in liver, kidney, lung, spleen, thymus, brain, and eye |
Identical and Related Proteins
Unique RefSeq proteins for LMP012818 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 162287208 | RefSeq | NP_445897 | 447 | fatty acid desaturase 1 |
Identical Sequences to LMP012818 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:162287208 | DBBJ | BAB69054.1 | 447 | delta-5 fatty acid desaturase [Rattus norvegicus] |
| GI:162287208 | GenBank | EDM12791.1 | 447 | fatty acid desaturase 1, isoform CRA_a [Rattus norvegicus] |
| GI:162287208 | SwissProt | Q920R3.1 | 447 | RecName: Full=Fatty acid desaturase 1; AltName: Full=Delta(5) fatty acid desaturase; Short=D5D; Short=Delta(5) desaturase; Short=Delta-5 desaturase [Rattus norvegicus] |
Related Sequences to LMP012818 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:162287208 | DBBJ | BAB69054.1 | 447 | delta-5 fatty acid desaturase [Rattus norvegicus] |
| GI:162287208 | GenBank | EDM12791.1 | 447 | fatty acid desaturase 1, isoform CRA_a [Rattus norvegicus] |
| GI:162287208 | SwissProt | Q920R3.1 | 447 | RecName: Full=Fatty acid desaturase 1; AltName: Full=Delta(5) fatty acid desaturase; Short=D5D; Short=Delta(5) desaturase; Short=Delta-5 desaturase [Rattus norvegicus] |