Gene/Proteome Database (LMPD)

LMPD ID
LMP012819
Gene ID
84587
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase C-like 1
Gene Symbol
Plcl1
Alternate Names
inactive phospholipase C-like protein 1; p130; PRIP1; PLC-L1; 130kDa-Ins(1,4,5)P3 binding protein; phospholipase C-related but catalytically inactive protein;
Chromosome
9
Map Location
9q31
Summary
inositol 1,4,5-trisphosphate binding protein [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Plcl1

Proteins

inactive phospholipase C-like protein 1
Refseq ID NP_445908
Protein GI 16758196
UniProt ID Q62688
mRNA ID NM_053456
Length 1096
MAEGAASREAPAPLDVAGGEDDPRAGADAASGDAAPEASGGRMRDRRSGVALPGNAGVPADSEAGLLEAARATPRRTSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEVEQGVTHVTEDMCLDIIRRYELSEDGRQKGFLAIDGFTQYLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGCRSIELDVSDGPDNEPILCNRNNMAMLLSFRSVLEVINKFAFVASEYPLILCLGNHCSLPQQRVMVQQMKKVFGNKLYTEAPLSSESYLPSPEKLKHMIIVKGKKLPSESDLLEGEVTDEDEEAEMSRRVSGDYNGEQKHIWLCRELSDLVSICKSVQYRDFELSMKTQNYWEICSFSETLASRIANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLLLHIKIISGQNFPKPKGACAKGDVIDPYVCVEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELTMVRFVILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSVKELCGLPPIASLKQCLLTLSSRLITSDSTPSVSLVMKDCFPYLEPLGTIPDVQKRMLAAYDLMIQESRVLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKAIESFAWNITVLKGQGDLLKNAKNEAVENIKQIQLACLSCGLSKGPGSAAEAKGKRSLEAIEEKESSEENGKL

Gene Information

Entrez Gene ID
84587
Gene Name
phospholipase C-like 1
Gene Symbol
Plcl1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0050811 IDA:MGI F GABA receptor binding
GO:0005509 IEA:InterPro F calcium ion binding
GO:0070679 IEA:InterPro F inositol 1,4,5 trisphosphate binding
GO:0004435 IEA:InterPro F phosphatidylinositol phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0006629 IEA:InterPro P lipid metabolic process
GO:0032228 IEA:InterPro P regulation of synaptic transmission, GABAergic

KEGG Pathway Links

KEGG Pathway ID Description
ko04727 GABAergic synapse
rno04727 GABAergic synapse

Domain Information

InterPro Annotations

Accession Description
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR028382 Inactive phospholipase C-like protein 1
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR001849 Pleckstrin homology domain
IPR011993 Pleckstrin homology-like domain

UniProt Annotations

Entry Information

Gene Name
phospholipase C-like 1
Protein Entry
PLCL1_RAT
UniProt ID
Q62688
Species
Rat

Comments

Comment Type Description
Caution In the PI-PLC X-box Asn-459 is present instead of the conserved His which is one of the active site residues. It is therefore expected that this protein lacks catalytic activity
Function Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Acts as a inhibitor of PPP1C. {ECO:0000269|PubMed:11278544, ECO:0000269|PubMed:8546702}.
Ptm Phosphorylation of Thr-94 resulted in dissociation of PPP1C from PRIP1 (By similarity). In vitro, phosphorylated by the catalytic subunit of PKA. {ECO:0000250, ECO:0000269|PubMed:11278544}.
Similarity Belongs to the PRIP family
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PH domain. {ECO:0000255|PROSITE- ProRule:PRU00145}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11278544, ECO:0000269|PubMed:8546702}.
Subunit Interacts with PPP2CA, GABA receptor beta subunits, GABA receptor gamma-2 subunits (By similarity). Interacts with Ins(1,4,5)P3, Ins(1,4,5,6)P4, GABARAP, and PPP1C. May form a ternary complex with GABA receptor beta subunit and GABARAP. The formation of a ternary complex with GABA receptor beta subunit and GABARAP could be the key step for facilitating the association of GABARAP with the GABA receptor gamma-2 subunit and to allow it to be transported at the right destination. {ECO:0000250, ECO:0000269|PubMed:11278544, ECO:0000269|PubMed:11867528, ECO:0000269|PubMed:8546702}.
Tissue Specificity Expressed in brain. Found in the granular cell and Purkinje cell layers in the cerebellum; and in the hippocampal pyramidal cells, dentate granule cells and pyramidal granule cells of the cerebral cortex in the cerebrum

Identical and Related Proteins

Unique RefSeq proteins for LMP012819 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758196 RefSeq NP_445908 1096 inactive phospholipase C-like protein 1

Identical Sequences to LMP012819 proteins

Reference Database Accession Length Protein Name
GI:16758196 EMBL CBU87766.1 1096 unnamed protein product [Rattus norvegicus]
GI:16758196 EMBL CBU96713.1 1096 unnamed protein product [Rattus norvegicus]
GI:16758196 GenBank AGX54701.1 1096 Sequence 9758 from patent US 8541208
GI:16758196 GenBank AGX64141.1 1096 Sequence 28392 from patent US 8541208

Related Sequences to LMP012819 proteins

Reference Database Accession Length Protein Name
GI:16758196 EMBL CBF74568.1 1096 unnamed protein product [Rattus norvegicus]
GI:16758196 EMBL CBU87766.1 1096 unnamed protein product [Rattus norvegicus]
GI:16758196 EMBL CBU96713.1 1096 unnamed protein product [Rattus norvegicus]