Gene/Proteome Database (LMPD)

LMPD ID
LMP012823
Gene ID
85240
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase C, beta 2
Gene Symbol
Plcb2
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; PLC-beta-2; PKC beta II; phospholipase C-beta-2; plcb2 {ECO:0000250|UniProtKB:Q00722}; phosphoinositide phospholipase C-beta-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-2;
Chromosome
3
Map Location
3q35
EC Number
3.1.4.11
Summary
may play a role in inositol mediated signal transduction of bitter taste perception [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Plcb2

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
Refseq ID NP_445930
Protein GI 16758232
UniProt ID O89040
mRNA ID NM_053478
Length 1183
MSLLNPVLLPPKVKAYLSQGERFIKWDDETSIASPVILRVDPKGYYLYWTHQSKEMEFLDVTSIRDTRFGKFAKIPKSQKLREVFNMDFPDNHFLLKTFTVVSGPDMVGLTFHNFVSYKENVGKDWAEDVLALAKHPMTANASRSTFLDKILVKLKMQLSPEGKIPVKNFFQMFPADRKRVEAALSACHLAKGKNDAINPEDFPESVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDPRLNSLLFPPARPEQVQALIDKYEPSGINVQRGQLSPEGMVWFLCGPENSVLAHDTLRIHQDMTQPLNHYFINSSHNTYLTAGQFSGPSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDILFKEAVEAIAESAFKTSPYPVILSFENHVDSPRQQAKMAEYCRTMFGETLLTEPLENFPLKPGMPLPSPEDLRGKILIKNKKNQFSGPASPNKKPDGVSEGGFPSSVPVEEDTGWTAEDRTEVEEGEEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFISFEFSAQKNRSYLVSSFTELKAYELLSKASMQFVDYNKRQMSRVYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMALFEFNGQSGYLLKHEFMRRQDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPTANSINPVWKEEPFIFEKILVPELASLRIAVMEEGGKFIGHRIIPINALHSGYHHLCLRSESNMPLTMPALFVFLEMKDYVPDTWADLTVALANPIKYFSAHDKKSVKLKEVTGSLPEKLFSGIPVASQSNGAPVSAGNGSTAPGTKAKEEATKEVAEPQTTSLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELQDPAASCKLRPGKGSRKKRIVPCEETIVVPREVLEGPDPRVQDLKDRLEQELQQQGEEQYRSVLKRKEQHVTEQIAKMMELAREKQAAELKSFKETSETDTKEMKKKLEAKRLERIQAMTKVTTDKVAQERLKREINNSHIQEVVQAVKQMTETLERHQEKLEEKQTACLEQIQAMEKQFQEKALAEYEAKMKGLEAEVKESMRACFKACFPTEAEEKPERPCEASEESCPQEPLVNKTDTQESRL

Gene Information

Entrez Gene ID
85240
Gene Name
phospholipase C, beta 2
Gene Symbol
Plcb2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031680 IDA:RGD C G-protein beta/gamma-subunit complex
GO:0005794 IDA:RGD C Golgi apparatus
GO:0005829 IDA:RGD C cytosol
GO:0005886 IDA:RGD C plasma membrane
GO:0031683 IDA:RGD F G-protein beta/gamma-subunit complex binding
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 NAS:UniProtKB F phosphatidylinositol phospholipase C activity
GO:0004629 IMP:RGD F phospholipase C activity
GO:0005543 IDA:RGD F phospholipid binding
GO:0004871 IDA:UniProtKB F signal transducer activity
GO:0001580 IDA:UniProtKB P detection of chemical stimulus involved in sensory perception of bitter taste
GO:0035556 IDA:UniProtKB P intracellular signal transduction
GO:0009395 NAS:UniProtKB P phospholipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
ko04261 Adrenergic signaling in cardiomyocytes
rno04261 Adrenergic signaling in cardiomyocytes
ko05143 African trypanosomiasis
rno05143 African trypanosomiasis
ko05010 Alzheimer's disease
rno05010 Alzheimer's disease
ko05146 Amoebiasis
rno05146 Amoebiasis
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko04973 Carbohydrate digestion and absorption
rno04973 Carbohydrate digestion and absorption
ko05142 Chagas disease (American trypanosomiasis)
rno05142 Chagas disease (American trypanosomiasis)
ko04062 Chemokine signaling pathway
rno04062 Chemokine signaling pathway
rno04725 Cholinergic synapse
ko04713 Circadian entrainment
rno04713 Circadian entrainment
ko04728 Dopaminergic synapse
rno04728 Dopaminergic synapse
ko04961 Endocrine and other factor-regulated calcium reabsorption
rno04961 Endocrine and other factor-regulated calcium reabsorption
ko04915 Estrogen signaling pathway
rno04915 Estrogen signaling pathway
ko04540 Gap junction
rno04540 Gap junction
ko04971 Gastric acid secretion
rno04971 Gastric acid secretion
ko04724 Glutamatergic synapse
rno04724 Glutamatergic synapse
ko04912 GnRH signaling pathway
rno04912 GnRH signaling pathway
ko05016 Huntington's disease
rno05016 Huntington's disease
ko04750 Inflammatory mediator regulation of TRP channels
rno04750 Inflammatory mediator regulation of TRP channels
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
M00130 Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
rno04911 Insulin secretion
ko04730 Long-term depression
rno04730 Long-term depression
ko04720 Long-term potentiation
rno04720 Long-term potentiation
ko04916 Melanogenesis
rno04916 Melanogenesis
rno01100 Metabolic pathways
ko04921 Oxytocin signaling pathway
rno04921 Oxytocin signaling pathway
ko04972 Pancreatic secretion
rno04972 Pancreatic secretion
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
rno04611 Platelet activation
ko04015 Rap1 signaling pathway
rno04015 Rap1 signaling pathway
ko04723 Retrograde endocannabinoid signaling
rno04723 Retrograde endocannabinoid signaling
ko04970 Salivary secretion
rno04970 Salivary secretion
rno04726 Serotonergic synapse
ko04742 Taste transduction
rno04742 Taste transduction
rno04919 Thyroid hormone signaling pathway
ko04918 Thyroid hormone synthesis
rno04918 Thyroid hormone synthesis
ko04270 Vascular smooth muscle contraction
rno04270 Vascular smooth muscle contraction
ko04310 Wnt signaling pathway
rno04310 Wnt signaling pathway
ko04022 cGMP-PKG signaling pathway
rno04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028403 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR014815 PLC-beta, C-terminal
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like

UniProt Annotations

Entry Information

Gene Name
phospholipase C, beta 2
Protein Entry
PLCB2_RAT
UniProt ID
O89040
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=1; Comment=A number of isoforms may be produced. ; Name=1; IsoId=O89040-1; Sequence=Displayed;
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Evidence= ; Note=Binds 1 Ca(2+) ion per subunit. ;
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This protein may be involved in the transduction of bitter taste stimuli. {ECO:0000250|UniProtKB:Q00722, ECO:0000303|PubMed:9860142}.
Miscellaneous The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha- 16
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PI-PLC X-box domain. {ECO:0000255|PROSITE- ProRule:PRU00270}.
Similarity Contains 1 PI-PLC Y-box domain. {ECO:0000255|PROSITE- ProRule:PRU00271}.
Subunit Interacts with RAC1
Tissue Specificity Expressed in the gustatory cells of the circumvallate papillae. Not detected in non-sensory lingual epithelium, brain, parotid gland, liver, uterus, lung, heart, adrenal gland, ovary, spleen, pancreas, intestine, thymus, kidney or muscle. {ECO:0000269|PubMed:8454637, ECO:0000269|PubMed:9860142}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012823 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758232 RefSeq NP_445930 1183 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

Identical Sequences to LMP012823 proteins

Reference Database Accession Length Protein Name
GI:16758232 EMBL CBU87838.1 1183 unnamed protein product [Rattus norvegicus]
GI:16758232 EMBL CBU96785.1 1183 unnamed protein product [Rattus norvegicus]
GI:16758232 GenBank AGX54773.1 1183 Sequence 9902 from patent US 8541208
GI:16758232 GenBank AGX64213.1 1183 Sequence 28536 from patent US 8541208

Related Sequences to LMP012823 proteins

Reference Database Accession Length Protein Name
GI:16758232 EMBL CBF74725.1 1183 unnamed protein product [Rattus norvegicus]
GI:16758232 GenBank AGX64213.1 1183 Sequence 28536 from patent US 8541208
GI:16758232 SwissProt O89040.1 1183 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; AltName: Full=Phosphoinositide phospholipase C-beta-2; AltName: Full=Phospholipase C-beta-2; Short=PLC-beta-2 [Rattus norvegicus]