Gene/Proteome Database (LMPD)

LMPD ID
LMP012827
Gene ID
85311
Species
Rattus norvegicus (Rat)
Gene Name
phospholipase A1 member A
Gene Symbol
Pla1a
Synonyms
Pspla1; Ps-pla1;
Alternate Names
phospholipase A1 member A; phosphatidylserine-specific phospholipase A1;
Chromosome
11
Map Location
11q21.3-q22
EC Number
3.1.1.-
Summary
serine specific phospholipase that catalyzes the hydrolysis of a fatty acyl residue at the sn-1 position of lysophosphatidylserine and phosphatidylserine [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pla1a

Proteins

phospholipase A1 member A precursor
Refseq ID NP_620237
Protein GI 20302059
UniProt ID P97535
mRNA ID NM_138882
Length 456
MCPGLWGTCFWLWGSLLWLSIGRSGNVPPTTQPKCTDFQSANLLRGTNLKVQFLLFTPSDPGCGQLVEEDSDIRNSEFNASLGTKLIIHGFRALGTKPSWINKFIRALLRAADANVIAVDWVYGSTGMYFSAVENVVKLSLEISRFLSKLLELGVSESSIHIIGVSLGAHVGGMVGHFYKGQLGRITGLDPAGPEYTRASLEERLDSGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPAFIHAGYSYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDCLDCFNPFLLSCPRIGLVERGGVKIEPLPKEVRVYLQTTSSAPYCVHHSLVEFNLKEKRKKDTSIEVTFLGNNVTSSVKITIPKDHLEGRGIIAHQNPHCQINQVKLKFHISSRVWRKDRTPIVGTFCTAPLPVNDSKKTVCIPEPVRLQVSMAVLRDLKMACV
sig_peptide: 1..24 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2770 peptide sequence: MCPGLWGTCFWLWGSLLWLSIGRS mat_peptide: 25..456 product: Phospholipase A1 member A experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P97535.1) calculated_mol_wt: 47450 peptide sequence: GNVPPTTQPKCTDFQSANLLRGTNLKVQFLLFTPSDPGCGQLVEEDSDIRNSEFNASLGTKLIIHGFRALGTKPSWINKFIRALLRAADANVIAVDWVYGSTGMYFSAVENVVKLSLEISRFLSKLLELGVSESSIHIIGVSLGAHVGGMVGHFYKGQLGRITGLDPAGPEYTRASLEERLDSGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPAFIHAGYSYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDCLDCFNPFLLSCPRIGLVERGGVKIEPLPKEVRVYLQTTSSAPYCVHHSLVEFNLKEKRKKDTSIEVTFLGNNVTSSVKITIPKDHLEGRGIIAHQNPHCQINQVKLKFHISSRVWRKDRTPIVGTFCTAPLPVNDSKKTVCIPEPVRLQVSMAVLRDLKMACV

Gene Information

Entrez Gene ID
85311
Gene Name
phospholipase A1 member A
Gene Symbol
Pla1a
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0016787 IEA:UniProtKB-KW F hydrolase activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
rno04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein_lipase_LIPH
IPR000734 Triacylglycerol lipase family

UniProt Annotations

Entry Information

Gene Name
phospholipase A1 member A
Protein Entry
PLA1A_RAT
UniProt ID
P97535
Species
Rat

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: Vmax=2.6 umol/min/mg enzyme with phosphatidylcholine as substrate ; Vmax=0.1 umol/min/mg enzyme with phosphatidylinositol as substrate ;
Function Hydrolyzes the ester bond at the sn-1 position of glycerophospholipids and produces 2-acyl lysophospholipids. Hydrolyzes phosphatidylserine (PS) in the form of liposomes and 1- acyl-2 lysophosphatidylserine (lyso-PS), but not triolein, phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidic acid (PA) or phosphatidylinositol (PI). Hydrolysis of lyso-PS in peritoneal mast cells activated by receptors for IgE leads to stimulate histamine production
Similarity Belongs to the AB hydrolase superfamily. Lipase family
Subcellular Location Secreted .

Identical and Related Proteins

Unique RefSeq proteins for LMP012827 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20302059 RefSeq NP_620237 456 phospholipase A1 member A precursor

Identical Sequences to LMP012827 proteins

Reference Database Accession Length Protein Name
GI:20302059 DBBJ BAA13672.1 456 PS-PLA1 [Rattus norvegicus]
GI:20302059 GenBank AAH78727.1 456 Phospholipase A1 member A [Rattus norvegicus]
GI:20302059 GenBank EDM11222.1 456 phosphatidylserine-specific phospholipase A1 [Rattus norvegicus]
GI:20302059 SwissProt P97535.1 456 RecName: Full=Phospholipase A1 member A; AltName: Full=Phosphatidylserine-specific phospholipase A1; Short=PS-PLA1; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012827 proteins

Reference Database Accession Length Protein Name
GI:20302059 DBBJ BAA13672.1 456 PS-PLA1 [Rattus norvegicus]
GI:20302059 GenBank EDM11222.1 456 phosphatidylserine-specific phospholipase A1 [Rattus norvegicus]
GI:20302059 SwissProt P97535.1 456 RecName: Full=Phospholipase A1 member A; AltName: Full=Phosphatidylserine-specific phospholipase A1; Short=PS-PLA1; Flags: Precursor [Rattus norvegicus]