Gene/Proteome Database (LMPD)

LMPD ID
LMP012830
Gene ID
89784
Species
Rattus norvegicus (Rat)
Gene Name
isopentenyl-diphosphate delta isomerase 1
Gene Symbol
Idi1
Alternate Names
isopentenyl-diphosphate Delta-isomerase 1; IPPI1; IPP isomerase 1; isopentenyl pyrophosphate isomerase 1;
Chromosome
17
Map Location
17q12.1
EC Number
5.3.3.2
Summary
catalyzes the interconversion of isopentenyl diphosphate to dimethylallyl diphosphate; an important component of the isoprenoid biosynthetic pathway [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Idi1

Proteins

isopentenyl-diphosphate Delta-isomerase 1
Refseq ID NP_445991
Protein GI 399567836
UniProt ID O35760
mRNA ID NM_053539
Length 283
MWRGRALAGVIGSALKGRGLEAEHAAESVEVRRSAQLLDTPLWNRCVLGQIRHSVTMPEINASNLDEKQVQLLAEMCILIDENDNKIGADTKKNCHLNENIDKGLIHRAFSVFLFNTENKLLLQQRSDAKITFPGCFTNSCCSHPLNNPGELEENDAMGVKRAAQRRLKAELGIPLEEVDLNEMNYLTRIYYKAQSDGIWGEHEIDYILFLRKNVTLNPDPNEIKSYCYVSKEELKEILKKEARGEIKLTPWFKIIADAFLFKWWDNLNHLSPFVDHEKIHRM

Gene Information

Entrez Gene ID
89784
Gene Name
isopentenyl-diphosphate delta isomerase 1
Gene Symbol
Idi1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005777 IDA:RGD C peroxisome
GO:0016787 IEA:InterPro F hydrolase activity
GO:0004452 TAS:RGD F isopentenyl-diphosphate delta-isomerase activity
GO:0000287 IEA:Ensembl F magnesium ion binding
GO:0030145 IEA:Ensembl F manganese ion binding
GO:0006695 TAS:RGD P cholesterol biosynthetic process
GO:0050992 IEA:UniProtKB-UniPathway P dimethylallyl diphosphate biosynthetic process
GO:0008299 IEA:UniProtKB-KW P isoprenoid biosynthetic process
GO:0035634 IEA:Ensembl P response to stilbenoid

KEGG Pathway Links

KEGG Pathway ID Description
M00095 C5 isoprenoid biosynthesis, mevalonate pathway
rno01100 Metabolic pathways
ko00900 Terpenoid backbone biosynthesis
rno00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5954496 Activation of gene expression by SREBF (SREBP)
5953924 Cholesterol biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954497 Regulation of cholesterol biosynthesis by SREBP (SREBF)

Domain Information

InterPro Annotations

Accession Description
IPR011876 Isopentenyl-diphosphate delta-isomerase, type 1
IPR000086 NUDIX hydrolase domain
IPR015797 NUDIX hydrolase domain-like

UniProt Annotations

Entry Information

Gene Name
isopentenyl-diphosphate delta isomerase 1
Protein Entry
IDI1_RAT
UniProt ID
O35760
Species
Rat

Comments

Comment Type Description
Catalytic Activity Isopentenyl diphosphate = dimethylallyl diphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence= ; Note=Binds 1 Mg(2+) ion per subunit. ;
Function Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Pathway Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.
Similarity Belongs to the IPP isomerase type 1 family
Similarity Contains 1 nudix hydrolase domain
Subcellular Location Peroxisome.
Subunit Monomer

Identical and Related Proteins

Unique RefSeq proteins for LMP012830 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
399567836 RefSeq NP_445991 283 isopentenyl-diphosphate Delta-isomerase 1

Identical Sequences to LMP012830 proteins

Reference Database Accession Length Protein Name
GI:399567836 GenBank EDL86437.1 283 isopentenyl-diphosphate delta isomerase [Rattus norvegicus]

Related Sequences to LMP012830 proteins

Reference Database Accession Length Protein Name
GI:399567836 GenBank EDL32280.1 283 isopentenyl-diphosphate delta isomerase [Mus musculus]
GI:399567836 GenBank EDL86437.1 283 isopentenyl-diphosphate delta isomerase [Rattus norvegicus]
GI:399567836 RefSeq NP_663335.2 283 isopentenyl-diphosphate Delta-isomerase 1 [Mus musculus]