Gene/Proteome Database (LMPD)

LMPD ID
LMP012831
Gene ID
89812
Species
Rattus norvegicus (Rat)
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Gene Symbol
Pip4k2b
Synonyms
Pip5k2b;
Alternate Names
phosphatidylinositol 5-phosphate 4-kinase type-2 beta; PIPKIIgamma; PIP4KII-beta; PI(5)P 4-kinase type II beta; diphosphoinositide kinase 2-beta; ptdIns(5)P-4-kinase isoform 2-beta; 1-phosphatidylinositol-5-phosphate 4-kinase B; phosphatidylinositol-phosphate kinase IIgamma; 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; 1-phosphatidylinositol-5-phosphate 4-kinase 2-beta; phosphatidylinositol-5-phosphate 4-kinase type-2 beta; phosphatidylinositol 5-phosphate 4-kinase type II beta; phosphatidylinositol-4-phosphate 5-kinase, type II, beta;
Chromosome
10
Map Location
10q31
EC Number
2.7.1.149
Summary
has similarity to phosphatidylinositol-5-phosphate 4-kinase IIalpha and IIgamma isoforms [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pip4k2b

Proteins

phosphatidylinositol 5-phosphate 4-kinase type-2 beta
Refseq ID NP_446002
Protein GI 16758316
UniProt ID O88377
mRNA ID NM_053550
Length 416
MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLRVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEETEVEDRAEEEECENDGVGGGLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT

Gene Information

Entrez Gene ID
89812
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Gene Symbol
Pip4k2b
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0016308 IEA:Ensembl F 1-phosphatidylinositol-4-phosphate 5-kinase activity
GO:0016309 IEA:UniProtKB-EC F 1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system
ko04810 Regulation of actin cytoskeleton
rno04810 Regulation of actin cytoskeleton

REACTOME Pathway Links

REACTOME Pathway ID Description
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954478 PI Metabolism
5953474 Phospholipid metabolism
5954499 Synthesis of PIPs at the plasma membrane

Domain Information

InterPro Annotations

Accession Description
IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Protein Entry
PI42B_RAT
UniProt ID
O88377
Species
Rat

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Function Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate
Ptm Phosphorylated on serine residues. Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels (By similarity)
Similarity Contains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein . Cell membrane {ECO:0000250}; Peripheral membrane protein . Nucleus {ECO:0000250}. Cytoplasm . Note=Associated with the plasma membrane and the endoplasmic reticulum
Subunit Homodimer. Binds TNFRSF1A. Interacts with PIP4K2A. Interaction with PIP4K2A suppresses ubiquitination by the SPOP/ CUL3 complex (By similarity)

Identical and Related Proteins

Unique RefSeq proteins for LMP012831 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758316 RefSeq NP_446002 416 phosphatidylinositol 5-phosphate 4-kinase type-2 beta

Identical Sequences to LMP012831 proteins

Reference Database Accession Length Protein Name
GI:16758316 GenBank AAC40203.1 416 phosphatidylinositol 5-phosphate 4-kinase beta [Rattus norvegicus]
GI:16758316 GenBank EDM05879.1 416 phosphatidylinositol-4-phosphate 5-kinase, type II, beta [Rattus norvegicus]
GI:16758316 SwissProt O88377.1 416 RecName: Full=Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; AltName: Full=1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; AltName: Full=Diphosphoinositide kinase 2-beta; AltName: Full=Phosphatidylinositol 5-phosphate 4-kinase type II beta; Short=PI(5)P 4-kinase type II beta; Short=PIP4KII-beta; AltName: Full=Phosphatidylinositol-phosphate kinase IIgamma; Short=PIPKIIgamma; AltName: Full=PtdIns(5)P-4-kinase isoform 2-beta [Rattus norvegicus]

Related Sequences to LMP012831 proteins

Reference Database Accession Length Protein Name
GI:16758316 GenBank AAC40203.1 416 phosphatidylinositol 5-phosphate 4-kinase beta [Rattus norvegicus]
GI:16758316 GenBank EDM05879.1 416 phosphatidylinositol-4-phosphate 5-kinase, type II, beta [Rattus norvegicus]
GI:16758316 SwissProt O88377.1 416 RecName: Full=Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; AltName: Full=1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; AltName: Full=Diphosphoinositide kinase 2-beta; AltName: Full=Phosphatidylinositol 5-phosphate 4-kinase type II beta; Short=PI(5)P 4-kinase type II beta; Short=PIP4KII-beta; AltName: Full=Phosphatidylinositol-phosphate kinase IIgamma; Short=PIPKIIgamma; AltName: Full=PtdIns(5)P-4-kinase isoform 2-beta [Rattus norvegicus]