Gene/Proteome Database (LMPD)

LMPD ID
LMP012835
Gene ID
89841
Species
Rattus norvegicus (Rat)
Gene Name
phosphate cytidylyltransferase 2, ethanolamine
Gene Symbol
Pcyt2
Synonyms
ET;
Alternate Names
ethanolamine-phosphate cytidylyltransferase; phosphorylethanolamine transferase; CTP:phopshoethanolamine cytidylyltransferase; CTP:phosphoethanolamine cytidylyltransferase;
Chromosome
10
Map Location
10q32.3
EC Number
2.7.7.14
Summary
plays a role in the CDP-ethanolamine pathway for phosphatidylethanolamine synthesis [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Pcyt2

Proteins

ethanolamine-phosphate cytidylyltransferase
Refseq ID NP_446020
Protein GI 16758340
UniProt ID O88637
mRNA ID NM_053568
Length 404
MIRNGHGAGGAAGLKGPGGQRTVRVWCDGCYDMVHYGHSNQLRQARAMGDYLIVGVHTDEEIAKHKGPPVFTQEERYKMVQAIKWVDEVVPAAPYVTTLETLDKHNCDFCVHGNDITLTVDGRDTYEEVKQAGRYRECKRTQGVSTTDLVGRMLLVTKAHHSSQEMSSEYREYADSFGKPPHPTPAGDTLSSEVSSQCPGGQSPWTGVSQFLQTSQKIIQFASGKEPQPGETVIYVAGAFDLFHIGHVDFLQEVHKLAKRPYVIAGLHFDQEVNRYKGKNYPIMNLHERTLSVLACRYVSEVVIGAPYSVTAELLNHFKVDLVCHGKTEIVPDRDGSDPYEEPKRRGIFCQIDSGSDLTTDLIVQRIIKNRLEYEARNQKKEAKELAFLEALRQQEAQPRGETD

Gene Information

Entrez Gene ID
89841
Gene Name
phosphate cytidylyltransferase 2, ethanolamine
Gene Symbol
Pcyt2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0004306 IDA:RGD F ethanolamine-phosphate cytidylyltransferase activity
GO:0006646 TAS:RGD P phosphatidylethanolamine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00564 Glycerophospholipid metabolism
rno00564 Glycerophospholipid metabolism
rno01100 Metabolic pathways
M00092 Phosphatidylethanolamine (PE) biosynthesis, ethanolamine => PE

REACTOME Pathway Links

REACTOME Pathway ID Description
5953473 Glycerophospholipid biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953474 Phospholipid metabolism
5954474 Synthesis of PE

Domain Information

InterPro Annotations

Accession Description
IPR004821 Cytidyltransferase-like domain
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

UniProt Annotations

Entry Information

Gene Name
phosphate cytidylyltransferase 2, ethanolamine
Protein Entry
PCY2_RAT
UniProt ID
O88637
Species
Rat

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O88637-1; Sequence=Displayed; Name=2; IsoId=O88637-2; Sequence=VSP_022116; Note=No experimental confirmation available.;
Catalytic Activity CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine.
Function Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine (By similarity)
Pathway Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.
Similarity Belongs to the cytidylyltransferase family

Identical and Related Proteins

Unique RefSeq proteins for LMP012835 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758340 RefSeq NP_446020 404 ethanolamine-phosphate cytidylyltransferase

Identical Sequences to LMP012835 proteins

Reference Database Accession Length Protein Name
GI:16758340 GenBank AAC28864.1 404 CTP:phosphoethanolamine cytidylyltransferase [Rattus norvegicus]
GI:16758340 GenBank EDM06868.1 404 phosphate cytidylyltransferase 2, ethanolamine, isoform CRA_a [Rattus norvegicus]
GI:16758340 SwissProt O88637.1 404 RecName: Full=Ethanolamine-phosphate cytidylyltransferase; AltName: Full=CTP:phosphoethanolamine cytidylyltransferase; AltName: Full=Phosphorylethanolamine transferase [Rattus norvegicus]

Related Sequences to LMP012835 proteins

Reference Database Accession Length Protein Name
GI:16758340 GenBank AAC28864.1 404 CTP:phosphoethanolamine cytidylyltransferase [Rattus norvegicus]
GI:16758340 GenBank EDM06868.1 404 phosphate cytidylyltransferase 2, ethanolamine, isoform CRA_a [Rattus norvegicus]
GI:16758340 SwissProt O88637.1 404 RecName: Full=Ethanolamine-phosphate cytidylyltransferase; AltName: Full=CTP:phosphoethanolamine cytidylyltransferase; AltName: Full=Phosphorylethanolamine transferase [Rattus norvegicus]