Gene/Proteome Database (LMPD)

LMPD ID
LMP012840
Gene ID
94199
Species
Rattus norvegicus (Rat)
Gene Name
dipeptidase 1 (renal)
Gene Symbol
Dpep1
Alternate Names
dipeptidase 1; renal dipeptidase; microsomal dipeptidase;
Chromosome
19
Map Location
19q12
EC Number
3.4.13.19
Summary
renal enzyme that cleaves proteins [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Dpep1

Proteins

dipeptidase 1 precursor
Refseq ID NP_446043
Protein GI 16758372
UniProt ID P31430
mRNA ID NM_053591
Length 410
MLIIWWFWSLLAICASDSFRNQAENIMRTTPVIDGHNDLPWQMLTLFNNQLRKSEANLSALAETHTNIPKLRAGFVGGQFWSAYMPCDTQNKDAVKRILEQIDVIHRMCQLYPETFECVTNSSDILQAFRRGKVASLIGVEGGHLIDSSLGVLRTLYHLGMRYLTLTHNCNTPWADNWLVDKGDDEAESQGLSPFGKLVLNEMNRLGVMIDLSHVSVATMKDALQLSKAPVIFSHSSAYSVCPHRRNVPDDVLQLVKSTNSLVMVNFYNQFVSCSDSATLSQVADHLDHIKKVAGAGAVGLGGDYDGVTNLPVGLEDVSKYPDLIAELLRRNWTETEVRGLLAENLLRVFSAVELVSNIMQVPEEETIPVEKLDGSCRTFYGHSRAPSIHLQIGALLASLASLVFSLHLL
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1953 peptide sequence: MLIIWWFWSLLAICAS mat_peptide: 17..384 product: Dipeptidase 1 experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P31430.2) calculated_mol_wt: 40864 peptide sequence: DSFRNQAENIMRTTPVIDGHNDLPWQMLTLFNNQLRKSEANLSALAETHTNIPKLRAGFVGGQFWSAYMPCDTQNKDAVKRILEQIDVIHRMCQLYPETFECVTNSSDILQAFRRGKVASLIGVEGGHLIDSSLGVLRTLYHLGMRYLTLTHNCNTPWADNWLVDKGDDEAESQGLSPFGKLVLNEMNRLGVMIDLSHVSVATMKDALQLSKAPVIFSHSSAYSVCPHRRNVPDDVLQLVKSTNSLVMVNFYNQFVSCSDSATLSQVADHLDHIKKVAGAGAVGLGGDYDGVTNLPVGLEDVSKYPDLIAELLRRNWTETEVRGLLAENLLRVFSAVELVSNIMQVPEEETIPVEKLDGSCRTFYGHS

Gene Information

Entrez Gene ID
94199
Gene Name
dipeptidase 1 (renal)
Gene Symbol
Dpep1
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0031225 IEA:UniProtKB-KW C anchored component of membrane
GO:0045177 ISS:UniProtKB C apical part of cell
GO:0042995 IEA:UniProtKB-KW C cell projection
GO:0005615 ISS:UniProtKB C extracellular space
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005886 ISS:UniProtKB C plasma membrane
GO:0034235 ISS:UniProtKB F GPI anchor binding
GO:0043027 ISS:UniProtKB F cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:0016805 TAS:RGD F dipeptidase activity
GO:0008239 IEA:InterPro F dipeptidyl-peptidase activity
GO:0070573 ISS:UniProtKB F metallodipeptidase activity
GO:0072341 ISS:UniProtKB F modified amino acid binding
GO:0008270 ISS:UniProtKB F zinc ion binding
GO:0016999 ISS:UniProtKB P antibiotic metabolic process
GO:0071277 ISS:UniProtKB P cellular response to calcium ion
GO:0035690 ISS:UniProtKB P cellular response to drug
GO:0071732 ISS:UniProtKB P cellular response to nitric oxide
GO:0050667 ISS:UniProtKB P homocysteine metabolic process
GO:0043066 ISS:UniProtKB P negative regulation of apoptotic process
GO:0030336 ISS:UniProtKB P negative regulation of cell migration
GO:0043154 ISS:UniProtKB P negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5953686 Aflatoxin activation and detoxification
5953493 Arachidonic acid metabolism
5953258 Biological oxidations
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954082 Synthesis of Leukotrienes (LT) and Eoxins (EX)

Domain Information

InterPro Annotations

Accession Description
IPR000180 Dipep_AS
IPR028536 Dpep1
IPR008257 Renal_dipep_fam

UniProt Annotations

Entry Information

Gene Name
dipeptidase 1 (renal)
Protein Entry
DPEP1_RAT
UniProt ID
P31430
Species
Rat

Comments

Comment Type Description
Catalytic Activity Hydrolysis of dipeptides
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Enzyme Regulation Inhibited by L-penicillamine
Function Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conjugates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the regulation of leukotriene activity.
Similarity Belongs to the peptidase M19 family
Subcellular Location Apical cell membrane; Lipid-anchor, GPI- anchor. Cell projection, microvillus membrane; Lipid-anchor, GPI- anchor. Note=Brush border membrane.
Subunit Homodimer; disulfide-linked.

Identical and Related Proteins

Unique RefSeq proteins for LMP012840 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758372 RefSeq NP_446043 410 dipeptidase 1 precursor

Identical Sequences to LMP012840 proteins

Reference Database Accession Length Protein Name
GI:16758372 GenBank AAH72476.1 410 Dipeptidase 1 (renal) [Rattus norvegicus]
GI:16758372 GenBank EDL92789.1 410 dipeptidase 1 (renal) [Rattus norvegicus]
GI:16758372 RefSeq XP_006255845.1 410 PREDICTED: dipeptidase 1 isoform X1 [Rattus norvegicus]
GI:16758372 SwissProt P31430.2 410 RecName: Full=Dipeptidase 1; AltName: Full=Microsomal dipeptidase; AltName: Full=Renal dipeptidase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012840 proteins

Reference Database Accession Length Protein Name
GI:16758372 GenBank AAH72476.1 410 Dipeptidase 1 (renal) [Rattus norvegicus]
GI:16758372 GenBank EDL92789.1 410 dipeptidase 1 (renal) [Rattus norvegicus]
GI:16758372 SwissProt P31430.2 410 RecName: Full=Dipeptidase 1; AltName: Full=Microsomal dipeptidase; AltName: Full=Renal dipeptidase; Flags: Precursor [Rattus norvegicus]