Gene/Proteome Database (LMPD)

LMPD ID
LMP012847
Gene ID
113965
Species
Rattus norvegicus (Rat)
Gene Name
hydroxyacyl-CoA dehydrogenase
Gene Symbol
Hadh
Synonyms
Hadhsc;
Alternate Names
hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; HCDH; short chain 3-hydroxyacyl-CoA dehydrogenase; short-chain 3-hydroxyacyl-CoA dehydrogenase; hydroxylacyl-Coenzyme A dehydrogenase short chain; hydroxylacyl-Coenzyme A dehydrogenase, short chain; L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain; medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase; medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase;
Chromosome
2
Map Location
2q43
EC Number
1.1.1.35
Summary
catalyzes the dehydrogenation of 3-hydroxyacyl-CoAs to their corresponding 3-ketoacyl-CoAs [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Hadh

Proteins

hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor
Refseq ID NP_476534
Protein GI 17105336
UniProt ID Q9WVK7
mRNA ID NM_057186
Length 314
MAFVTRQFVRSMSSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAADEFVEKTLSSLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAIRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMDPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK
transit_peptide: 1..12 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (Q9WVK7.1) calculated_mol_wt: 1473 peptide sequence: MAFVTRQFVRSM mat_peptide: 13..314 product: hydroxyacyl-coenzyme A dehydrogenase, mitochondrial calculated_mol_wt: 32993 peptide sequence: SSSSSASAAAKKILIKHVTVIGGGLMGAGIAQVAAATGHTVVLVDQTEDILAKSKKGIEESLKRMAKKKFTENPKAADEFVEKTLSSLSTSTDAASVVHSTDLVVEAIVENLKLKNELFQRLDKFAAEHTIFASNTSSLQITNIANATTRQDRFAGLHFFNPVPMMKLVEVIKTPMTSQKTFESLVDFCKTLGKHPVSCKDTPGFIVNRLLVPYLIEAIRLHERGDASKEDIDTAMKLGAGYPMGPFELLDYVGLDTTKFILDGWHEMDPENPLFQPSPSMNNLVAQKKLGKKTGEGFYKYK

Gene Information

Entrez Gene ID
113965
Gene Name
hydroxyacyl-CoA dehydrogenase
Gene Symbol
Hadh
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005743 IEA:Ensembl C mitochondrial inner membrane
GO:0005634 IEA:Ensembl C nucleus
GO:0003857 IMP:RGD F 3-hydroxyacyl-CoA dehydrogenase activity
GO:0070403 IEA:InterPro F NAD+ binding
GO:0006635 IMP:RGD P fatty acid beta-oxidation
GO:0046676 IMP:RGD P negative regulation of insulin secretion
GO:0014823 IDA:RGD P response to activity
GO:0042493 IDA:RGD P response to drug
GO:0009725 IEP:RGD P response to hormone
GO:0032868 IEP:RGD P response to insulin

KEGG Pathway Links

KEGG Pathway ID Description
ko00650 Butanoate metabolism
rno00650 Butanoate metabolism
M00085 Fatty acid biosynthesis, elongation, mitochondria
ko00071 Fatty acid degradation
rno00071 Fatty acid degradation
ko00062 Fatty acid elongation
rno00062 Fatty acid elongation
ko01212 Fatty acid metabolism
rno01212 Fatty acid metabolism
ko00310 Lysine degradation
rno00310 Lysine degradation
M00032 Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
rno01100 Metabolic pathways
ko00380 Tryptophan metabolism
rno00380 Tryptophan metabolism
ko00280 Valine, leucine and isoleucine degradation
rno00280 Valine, leucine and isoleucine degradation
M00087 beta-Oxidation

REACTOME Pathway Links

REACTOME Pathway ID Description
5953500 Beta oxidation of butanoyl-CoA to acetyl-CoA
5953503 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA
5953501 Beta oxidation of hexanoyl-CoA to butanoyl-CoA
5953496 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA
5953502 Beta oxidation of octanoyl-CoA to hexanoyl-CoA
5953288 Fatty acid, triacylglycerol, and ketone body metabolism
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5953287 Mitochondrial Fatty Acid Beta-Oxidation
5953497 mitochondrial fatty acid beta-oxidation of saturated fatty acids

Domain Information

InterPro Annotations

Accession Description
IPR022694 3-hydroxyacyl-CoA dehydrogenase
IPR006108 3-hydroxyacyl-CoA dehydrogenase, C-terminal
IPR006176 3-hydroxyacyl-CoA dehydrogenase, NAD binding
IPR006180 3-hydroxyacyl-CoA dehydrogenase, conserved site
IPR008927 6-phosphogluconate dehydrogenase, C-terminal-like
IPR013328 Dehydrogenase, multihelical
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
hydroxyacyl-CoA dehydrogenase
Protein Entry
HCDH_RAT
UniProt ID
Q9WVK7
Species
Rat

Comments

Comment Type Description
Catalytic Activity (S)-3-hydroxyacyl-CoA + NAD(+) = 3-oxoacyl-CoA + NADH.
Function Plays an essential role in the mitochondrial beta- oxidation of short chain fatty acids. Exerts it highest activity toward 3-hydroxybutyryl-CoA.
Pathway Lipid metabolism; fatty acid beta-oxidation.
Ptm Succinylation at Lys-81, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity)
Similarity Belongs to the 3-hydroxyacyl-CoA dehydrogenase family
Subcellular Location Mitochondrion matrix.
Subunit Homodimer

Identical and Related Proteins

Unique RefSeq proteins for LMP012847 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
17105336 RefSeq NP_476534 314 hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor

Identical Sequences to LMP012847 proteins

Reference Database Accession Length Protein Name
GI:17105336 GenBank AAD42162.1 314 L-3-hydroxyacyl-CoA dehydrogenase precursor [Rattus norvegicus]
GI:17105336 GenBank EDL82212.1 314 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain, isoform CRA_a [Rattus norvegicus]
GI:17105336 SwissProt Q9WVK7.1 314 RecName: Full=Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Short=HCDH; AltName: Full=Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; AltName: Full=Short-chain 3-hydroxyacyl-CoA dehydrogenase; Flags: Precursor [Rattus norvegicus]

Related Sequences to LMP012847 proteins

Reference Database Accession Length Protein Name
GI:17105336 GenBank AAD42162.1 314 L-3-hydroxyacyl-CoA dehydrogenase precursor [Rattus norvegicus]
GI:17105336 GenBank EDL82212.1 314 L-3-hydroxyacyl-Coenzyme A dehydrogenase, short chain, isoform CRA_a [Rattus norvegicus]
GI:17105336 SwissProt Q9WVK7.1 314 RecName: Full=Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Short=HCDH; AltName: Full=Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase; AltName: Full=Short-chain 3-hydroxyacyl-CoA dehydrogenase; Flags: Precursor [Rattus norvegicus]