Gene/Proteome Database (LMPD)
LMPD ID
LMP012852
Gene ID
Species
Rattus norvegicus (Rat)
Gene Name
inositol polyphosphate-5-phosphatase E
Gene Symbol
Alternate Names
72 kDa inositol polyphosphate 5-phosphatase; pharbin; inositol polyphosphate 5-phosphatase; 5-phosphatase that induces arborization; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type IV;
Chromosome
3
Map Location
3p13
Summary
hydrolyzes the 5-phosphate group of inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, and phosphatidylinositol 4, 5-bisphosphate [RGD, Feb 2006]
Orthologs
Proteins
72 kDa inositol polyphosphate 5-phosphatase | |
---|---|
Refseq ID | NP_446084 |
Protein GI | 449020140 |
mRNA ID | NM_053632 |
Length | 648 |
MPSKSACLRHTEAPGQLEGRMLQGQLSNPEKKLIPTSASLPAADSQSSQTNSMPPLSMPAKPSNQNLQAKANLITPQPPIRPKLERTLSLDDKGWRRRRFRGSQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKPRRATGSEGGSPSLWSDCLSGMISTSLDLLHREAASGGPHSRLASLRATHTPPAMDLNIASSSLRTANKVDPEHTDYKLRMQNRLVRAHSNLGPSRPRSPLAGDDHSIHSARSSFSLLAPIRTKDIRSRSYLEGSLLASGALLGADELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGVQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYNRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQDPEVDVLALLQHDQLTREMKKGSIFKGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQEALKSQSSSAVCTVS |
Gene Information
Entrez Gene ID
Gene Name
inositol polyphosphate-5-phosphatase E
Gene Symbol
Species
Rattus norvegicus
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005794 | IEA:UniProtKB-KW | C | Golgi apparatus |
GO:0005930 | ISS:UniProtKB | C | axoneme |
GO:0005737 | IDA:RGD | C | cytoplasm |
GO:0005856 | IEA:UniProtKB-KW | C | cytoskeleton |
GO:0005886 | IDA:RGD | C | plasma membrane |
GO:0004445 | IMP:RGD | F | inositol-polyphosphate 5-phosphatase activity |
GO:0004439 | IEA:UniProtKB-EC | F | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity |
GO:0046856 | IEA:InterPro | P | phosphatidylinositol dephosphorylation |
GO:0010976 | IMP:RGD | P | positive regulation of neuron projection development |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Gene Name
inositol polyphosphate-5-phosphatase E
Species
Rat
Comments
Comment Type | Description |
---|---|
Catalytic Activity | 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. {ECO:0000269|PubMed:10405344}. |
Caution | The N-terminus was extended using the genomic sequence, in analogy to ortholog sequences. {ECO:0000305}. |
Function | Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5- bisphosphate to phosphatidylinositol 4-phosphate. Can convert lipid substrates, but also water soluble inositol phosphates. {ECO:0000269|PubMed:10405344}. |
Sequence Caution | Sequence=BAA82150.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Similarity | Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type IV family. {ECO:0000305}. |
Subcellular Location | Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9JII1}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9JII1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JII1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JII1}. Cell membrane {ECO:0000269|PubMed:10405344}; Peripheral membrane protein {ECO:0000269|PubMed:10405344}; Cytoplasmic side {ECO:0000269|PubMed:10405344}. Cell projection, ruffle {ECO:0000269|PubMed:10405344}. Cytoplasm {ECO:0000269|PubMed:10405344}. Note=Peripheral membrane protein associated with Golgi stacks. {ECO:0000250|UniProtKB:Q9JII1}. |
Subunit | Interacts (when prenylated) with PDE6D; this is important for normal location in cilia. {ECO:0000250|UniProtKB:Q9NRR6}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP012852 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
449020140 | RefSeq | NP_446084 | 648 | 72 kDa inositol polyphosphate 5-phosphatase |
Identical Sequences to LMP012852 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:449020140 | GenBank | EDL93496.1 | 648 | rCG45879, isoform CRA_b [Rattus norvegicus] |
GI:449020140 | GenBank | EDL93498.1 | 648 | rCG45879, isoform CRA_b [Rattus norvegicus] |
GI:449020140 | RefSeq | XP_006233729.1 | 648 | PREDICTED: 72 kDa inositol polyphosphate 5-phosphatase isoform X1 [Rattus norvegicus] |
Related Sequences to LMP012852 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:449020140 | GenBank | EDL93496.1 | 648 | rCG45879, isoform CRA_b [Rattus norvegicus] |
GI:449020140 | GenBank | EDL93498.1 | 648 | rCG45879, isoform CRA_b [Rattus norvegicus] |
GI:449020140 | RefSeq | XP_006233729.1 | 648 | PREDICTED: 72 kDa inositol polyphosphate 5-phosphatase isoform X1 [Rattus norvegicus] |