Gene/Proteome Database (LMPD)

LMPD ID
LMP012852
Gene ID
114089
Species
Rattus norvegicus (Rat)
Gene Name
inositol polyphosphate-5-phosphatase E
Gene Symbol
Inpp5e
Alternate Names
72 kDa inositol polyphosphate 5-phosphatase; pharbin; inositol polyphosphate 5-phosphatase; 5-phosphatase that induces arborization; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type IV;
Chromosome
3
Map Location
3p13
Summary
hydrolyzes the 5-phosphate group of inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, and phosphatidylinositol 4, 5-bisphosphate [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Inpp5e

Proteins

72 kDa inositol polyphosphate 5-phosphatase
Refseq ID NP_446084
Protein GI 449020140
mRNA ID NM_053632
Length 648
MPSKSACLRHTEAPGQLEGRMLQGQLSNPEKKLIPTSASLPAADSQSSQTNSMPPLSMPAKPSNQNLQAKANLITPQPPIRPKLERTLSLDDKGWRRRRFRGSQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKPRRATGSEGGSPSLWSDCLSGMISTSLDLLHREAASGGPHSRLASLRATHTPPAMDLNIASSSLRTANKVDPEHTDYKLRMQNRLVRAHSNLGPSRPRSPLAGDDHSIHSARSSFSLLAPIRTKDIRSRSYLEGSLLASGALLGADELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGVQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYNRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQDPEVDVLALLQHDQLTREMKKGSIFKGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFRVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQEALKSQSSSAVCTVS

Gene Information

Entrez Gene ID
114089
Gene Name
inositol polyphosphate-5-phosphatase E
Gene Symbol
Inpp5e
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005930 ISS:UniProtKB C axoneme
GO:0005737 IDA:RGD C cytoplasm
GO:0005856 IEA:UniProtKB-KW C cytoskeleton
GO:0005794 IEA:UniProtKB-KW C Golgi apparatus
GO:0005886 IDA:RGD C plasma membrane
GO:0004445 IMP:RGD F inositol-polyphosphate 5-phosphatase activity
GO:0004439 IEA:UniProtKB-EC F phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
GO:0046856 IEA:InterPro P phosphatidylinositol dephosphorylation
GO:0010976 IMP:RGD P positive regulation of neuron projection development

KEGG Pathway Links

KEGG Pathway ID Description
ko00562 Inositol phosphate metabolism
rno00562 Inositol phosphate metabolism
rno01100 Metabolic pathways
ko04070 Phosphatidylinositol signaling system
rno04070 Phosphatidylinositol signaling system

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase
IPR000300 Inositol polyphosphate-related phosphatase

UniProt Annotations

Entry Information

Gene Name
inositol polyphosphate-5-phosphatase E
Species
Rat

Comments

Comment Type Description
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. {ECO:0000269|PubMed:10405344}.
Caution The N-terminus was extended using the genomic sequence, in analogy to ortholog sequences. {ECO:0000305}.
Function Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5- bisphosphate to phosphatidylinositol 4-phosphate. Can convert lipid substrates, but also water soluble inositol phosphates. {ECO:0000269|PubMed:10405344}.
Sequence Caution Sequence=BAA82150.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type IV family. {ECO:0000305}.
Subcellular Location Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9JII1}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9JII1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JII1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9JII1}. Cell membrane {ECO:0000269|PubMed:10405344}; Peripheral membrane protein {ECO:0000269|PubMed:10405344}; Cytoplasmic side {ECO:0000269|PubMed:10405344}. Cell projection, ruffle {ECO:0000269|PubMed:10405344}. Cytoplasm {ECO:0000269|PubMed:10405344}. Note=Peripheral membrane protein associated with Golgi stacks. {ECO:0000250|UniProtKB:Q9JII1}.
Subunit Interacts (when prenylated) with PDE6D; this is important for normal location in cilia. {ECO:0000250|UniProtKB:Q9NRR6}.

Identical and Related Proteins

Unique RefSeq proteins for LMP012852 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
449020140 RefSeq NP_446084 648 72 kDa inositol polyphosphate 5-phosphatase

Identical Sequences to LMP012852 proteins

Reference Database Accession Length Protein Name
GI:449020140 GenBank EDL93496.1 648 rCG45879, isoform CRA_b [Rattus norvegicus]
GI:449020140 GenBank EDL93498.1 648 rCG45879, isoform CRA_b [Rattus norvegicus]
GI:449020140 RefSeq XP_006233729.1 648 PREDICTED: 72 kDa inositol polyphosphate 5-phosphatase isoform X1 [Rattus norvegicus]

Related Sequences to LMP012852 proteins

Reference Database Accession Length Protein Name
GI:449020140 GenBank EDL93496.1 648 rCG45879, isoform CRA_b [Rattus norvegicus]
GI:449020140 GenBank EDL93498.1 648 rCG45879, isoform CRA_b [Rattus norvegicus]
GI:449020140 RefSeq XP_006233729.1 648 PREDICTED: 72 kDa inositol polyphosphate 5-phosphatase isoform X1 [Rattus norvegicus]