Gene/Proteome Database (LMPD)

LMPD ID
LMP012854
Gene ID
114098
Species
Rattus norvegicus (Rat)
Gene Name
leukotriene B4 receptor 2
Gene Symbol
Ltb4r2
Alternate Names
leukotriene B4 receptor 2; LTB4-R2; LTB4-R 2; LTB4 receptor JULF2;
Chromosome
15
Map Location
15p13
Summary
mouse homolog is a chemoattractant for myeloid leukocytes [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Ltb4r2

Proteins

leukotriene B4 receptor 2
Refseq ID NP_446092
Protein GI 16758450
UniProt ID Q924U0
mRNA ID NM_053640
Length 358
MSVCYRPPGNETLLSWKGSRATGTAFLLLAALLGLPGNGFVVWSLAGWRPTAGRPLAATLVLHLALADGAVLLLTPLFVAFLSRQAWPLGQVGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLGVWLAALVLAVPAAVYRHLWGDRVCQLCHPSAVHAAAHLSLETLTAFVLPFGTVLGCYGVTLARLRGARWGSGRQGTRVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGPLARLGGAGQAARAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARVGSRSREGTMELRTTPRLKVVGQGRGYGDPGGGGRMEKDSQEW

Gene Information

Entrez Gene ID
114098
Gene Name
leukotriene B4 receptor 2
Gene Symbol
Ltb4r2
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0001632 IEA:Ensembl F leukotriene B4 receptor activity
GO:0051546 IEA:Ensembl P keratinocyte migration

KEGG Pathway Links

KEGG Pathway ID Description
ko04020 Calcium signaling pathway
rno04020 Calcium signaling pathway
ko04080 Neuroactive ligand-receptor interaction
rno04080 Neuroactive ligand-receptor interaction

REACTOME Pathway Links

REACTOME Pathway ID Description
5954122 Class A/1 (Rhodopsin-like receptors)
5954202 Eicosanoid ligand-binding receptors
5953653 G alpha (q) signalling events
5953642 GPCR downstream signaling
5953758 GPCR ligand binding
5953537 Gastrin-CREB signalling pathway via PKC and MAPK
5954203 Leukotriene receptors
5953381 Signal Transduction
5953391 Signaling by GPCR

Domain Information

InterPro Annotations

Accession Description
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR003981 Leukotriene B4 receptor
IPR003982 Leukotriene B4 type 2 receptor

UniProt Annotations

Entry Information

Gene Name
leukotriene B4 receptor 2
Protein Entry
LT4R2_RAT
UniProt ID
Q924U0
Species
Rat

Comments

Comment Type Description
Function Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity)
Similarity Belongs to the G-protein coupled receptor 1 family
Subcellular Location Cell membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP012854 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
16758450 RefSeq NP_446092 358 leukotriene B4 receptor 2

Identical Sequences to LMP012854 proteins

Reference Database Accession Length Protein Name
GI:16758450 DBBJ BAB60815.1 358 second LTB4 receptor JULF2 [Rattus norvegicus]
GI:16758450 RefSeq XP_008768880.1 358 PREDICTED: leukotriene B4 receptor 2 isoform X1 [Rattus norvegicus]
GI:16758450 SwissProt Q924U0.1 358 RecName: Full=Leukotriene B4 receptor 2; Short=LTB4-R 2; Short=LTB4-R2; AltName: Full=LTB4 receptor JULF2 [Rattus norvegicus]

Related Sequences to LMP012854 proteins

Reference Database Accession Length Protein Name
GI:16758450 DBBJ BAB60815.1 358 second LTB4 receptor JULF2 [Rattus norvegicus]
GI:16758450 RefSeq XP_008768880.1 358 PREDICTED: leukotriene B4 receptor 2 isoform X1 [Rattus norvegicus]
GI:16758450 SwissProt Q924U0.1 358 RecName: Full=Leukotriene B4 receptor 2; Short=LTB4-R 2; Short=LTB4-R2; AltName: Full=LTB4 receptor JULF2 [Rattus norvegicus]