Gene/Proteome Database (LMPD)

LMPD ID
LMP012856
Gene ID
114100
Species
Rattus norvegicus (Rat)
Gene Name
sterol-C5-desaturase
Gene Symbol
Sc5d
Synonyms
Sc5dl;
Alternate Names
lathosterol oxidase; sterol-C5-desaturase (fungal ERG3 delta-5-desaturase)-like; sterol-C5-desaturase (fungal ERG3, delta-5-desaturase)-like; sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog; sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like;
Chromosome
8
Map Location
8q22
Summary
human homolog is an enzyme involved in catalyzing the conversion of lathosterol into 7-dehydrocholesterol; involved in the synthesis of cholesterol [RGD, Feb 2006]
Orthologs
View orthologs and multiple alignments for Sc5d

Proteins

lathosterol oxidase
Refseq ID NP_446094
Protein GI 25742651
UniProt ID Q9EQS5
mRNA ID NM_053642
Length 299
MDLVLSAADYYFFTPYVYPATWPEDNIIRQTVSLLVVTNLGAYILYFFCATLSYYFVYDHSLMKHPQFLKNQVSREIMFTVKSLPWISIPTVSLFLLELRGYSKLYDDIGDFPNGWIHLIMSVISFLFFTDMLIYWIHRGLHHRLLYKHIHKPHHIWKIPTPFASHAFHPVDGFLQSLPYHIYPFVFPLHKVVYLGLYVLVNVWTISIHDGDFRVPQIFRPFINGSAHHTDHHMLFDYNYGQYFTLWDRIGGSFKHPSSFEGKGPHSYVKNMTEKESNSLAENGCKSKKLCNGEFTKNE

Gene Information

Entrez Gene ID
114100
Gene Name
sterol-C5-desaturase
Gene Symbol
Sc5d
Species
Rattus norvegicus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0043231 IDA:RGD C intracellular membrane-bounded organelle
GO:0000248 IDA:RGD F C-5 sterol desaturase activity
GO:0005506 IEA:InterPro F iron ion binding
GO:0050046 TAS:RGD F lathosterol oxidase activity
GO:0033490 IDA:RGD P cholesterol biosynthetic process via lathosterol
GO:0006633 IEA:InterPro P fatty acid biosynthetic process
GO:0006631 TAS:RGD P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
M00101 Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
rno01100 Metabolic pathways
ko00100 Steroid biosynthesis
rno00100 Steroid biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5954496 Activation of gene expression by SREBF (SREBP)
5953924 Cholesterol biosynthesis
5953250 Metabolism
5953289 Metabolism of lipids and lipoproteins
5954497 Regulation of cholesterol biosynthesis by SREBP (SREBF)

Domain Information

InterPro Annotations

Accession Description
IPR006694 Fatty_acid_hydroxylase

UniProt Annotations

Entry Information

Gene Name
sterol-C5-desaturase
Protein Entry
Q9EQS5_RAT
UniProt ID
Q9EQS5
Species
Rat

Identical and Related Proteins

Unique RefSeq proteins for LMP012856 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
25742651 RefSeq NP_446094 299 lathosterol oxidase

Identical Sequences to LMP012856 proteins

Reference Database Accession Length Protein Name
GI:25742651 DBBJ BAB19798.1 299 sterol C5-desaturase [Rattus norvegicus]
GI:25742651 GenBank AAH81704.1 299 Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like [Rattus norvegicus]
GI:25742651 GenBank EDL95251.1 299 sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae), isoform CRA_a [Rattus norvegicus]

Related Sequences to LMP012856 proteins

Reference Database Accession Length Protein Name
GI:25742651 DBBJ BAB19798.1 299 sterol C5-desaturase [Rattus norvegicus]
GI:25742651 GenBank AAH81704.1 299 Sterol-C5-desaturase (ERG3 delta-5-desaturase homolog, S. cerevisiae)-like [Rattus norvegicus]
GI:25742651 GenBank EDL95251.1 299 sterol-C5-desaturase (fungal ERG3, delta-5-desaturase) homolog (S. cerevisae), isoform CRA_a [Rattus norvegicus]